[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629882":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":33,"locations":33,"responsibleParty":34,"collaborators":33,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":40,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":33,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":64,"whyStopped":33,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":33},{"fullName":5,"class":6},"King Edward Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Fat Grafting Plus Standard Wound Care","EXPERIMENTAL","Participants in this arm will receive autologous fat grafting in addition to standard wound care. Fat will be harvested from the patient's thigh using the Coleman technique, processed into nano-fat through sequential filtering and centrifugation, and injected into the wound bed and margins. The typical volume is approximately 0.4 cc per cm² along wound edges and 0.6 cc per cm² within the wound bed. Wounds will be dressed with tulle gauze, with dressings changed every 48-72 hours. Pain, wound size, and wound healing will be monitored for 21 days, with rescue analgesia provided if VAS \\> 3.",[13],"Procedure: Autologous Fat Grafting",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Wound Care Alone","ACTIVE_COMPARATOR","Participants in this arm will receive standard wound care alone without fat grafting. Wounds will be cleaned with povidone-iodine and dressed with tulle gauze and cotton gauze layers. Dressings will be changed every 48-72 hours. Pain, wound size, and wound healing will be monitored for 21 days, with rescue analgesia provided if VAS \\>3.",[19],"Procedure: Standard Wound Care",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Autologous Fat Grafting","Participants will receive autologous fat grafting in addition to standard wound care. Fat will be harvested from the patient's thigh using the Coleman technique, processed into nano-fat through sequential filtering and centrifugation, and injected into the wound bed and margins. The injection volume is approximately 0.4 cc per cm² along wound edges and 0.6 cc per cm² within the wound bed. After injection, wounds will be dressed with tulle gauze, with dressing changes every 48-72 hours. Pain will be assessed using the Visual Analog Scale (VAS) three times daily for 21 days. Wound size, healing percentage, and complications, including infection, will also be monitored. Rescue analgesia (IV Toradol 0.5 mg\u002Fkg) will be administered if VAS \\> 3.",[9],[27,28],"Nano-Fat Injection","Autologous Adipose Tissue Grafting",{"type":22,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Standard Wound Care","Participants will receive standard wound care without fat grafting. Wounds will be cleaned with povidone-iodine and dressed with tulle gauze and a secondary cotton gauze layer. Dressing changes will occur every 48-72 hours. Pain will be assessed using the VAS three times daily for 21 days. Wound size, healing percentage, and complications, including infection, will also be monitored. Rescue analgesia (IV Toradol 0.5 mg\u002Fkg) will be administered if VAS \\>3.",[15],null,{"type":35,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Farrukh Aslam","Assosiate Professor","100629882","comparison-of-pain-reduction-in-painful-chronic-wounds-with-and-without-fat-grafting-100629882",false,"NCT07480447","Comparison of Pain Reduction in Painful Chronic Wounds With and Without Fat Grafting","Comparison of Pain Reduction in Chronic Wounds Treated With and Without Autologous Fat Grafting: A Randomized Controlled Trial","PAINFAT","Inclusion Criteria:\n\n* • 3 months old chronic wound (Venous arterial, traumatic, burn and diabetic) having mean VAS Pain score \\>3 at rest\n\n  * Wound area between 4 cm² to 10 cm²\n  * Aged 20-60 years.\n  * Both male and female\n\nExclusion Criteria:\n\n* • Active wound infection.\n\n  * Wounds due to malignancy or irradiation.\n  * Pregnant or lactating females\n  * Smokers","ALL","20 Years","60 Years",{"count":50,"type":51},62,"ESTIMATED","INTERVENTIONAL",[54],"NA","Chronic wounds, such as those caused by diabetes, burns, or poor blood circulation, often heal slowly and can cause significant pain, affecting daily life and quality of life. This study aims to evaluate whether autologous fat grafting-a procedure in which a patient's own fat tissue is injected into the wound-can reduce pain and improve healing in chronic wounds compared to standard care without fat grafting.\n\nWe will enroll 62 adult patients with chronic wounds lasting more than 3 months. Participants will be randomly assigned to two groups: one group will receive fat grafting along with standard wound care, and the other group will receive standard wound care alone. Pain will be measured using a Visual Analog Scale (VAS) over 21 days after treatment. Wound healing and any complications will also be monitored.\n\nThe results of this study will help determine if autologous fat grafting is an effective and safe method to reduce pain and improve recovery in patients with chronic wounds.",[57,58],"Wound and Injuries","Pain",[60,61,62,63],"Chronic Wounds","Pain Reduction","Nanofat Grafting","Autologous fat grafting","NOT_YET_RECRUITING","2026-03-14",{"date":67,"type":68},"2026-03-18","ACTUAL",{"date":70,"type":51},"2026-05-01",{"date":72,"type":51},"2026-11-01",{"name":5,"class":6}]