[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589264":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":11,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":11,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":11,"enrollmentInfo":67,"targetDuration":11,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":39,"whyStopped":11,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of Medicine and Pharmacy at Ho Chi Minh City","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"standard trabeculectomy with 5FU","ACTIVE_COMPARATOR",null,[13],"Procedure: Trabeculectomy with 5FU",{"label":15,"type":16,"description":11,"interventionNames":17},"Phacoemulsification with Goniosynechialysis","EXPERIMENTAL",[18],"Procedure: Phacoemulsification with Goniosynechialysis",[20,26],{"type":21,"name":15,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","This procedure involves standard phacoemulsification cataract surgery combined with goniosynechialysis, which mechanically separates peripheral anterior synechiae to open the anterior chamber angle. It aims to both remove the cataractous lens and restore aqueous outflow in patients with primary angle-closure glaucoma.",[15],[25],"Phaco-GSL",{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":11},"Trabeculectomy with 5FU","Trabeculectomy is a glaucoma filtration procedure designed to lower intraocular pressure by creating a new drainage pathway from the anterior chamber to the sub-conjunctival space. It is considered the standard surgical intervention for medically uncontrolled glaucoma.",[9],[31],{"name":32,"role":33,"phone":34,"phoneExt":11,"email":35},"Hai Thanh Le, MSc","CONTACT","+61 450390405","haileopto@gmail.com",[37],{"facility":38,"status":39,"city":40,"state":11,"zip":11,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"HCMC University of Medicine and Pharmacy","RECRUITING","Ho Chi Minh City","Vietnam","VN",{"type":44,"coordinates":45},"Point",[46,47],106.62965,10.82302,{"lat":47,"lon":46},[50],{"name":51,"role":33,"phone":52,"phoneExt":11,"email":53},"Phuc Hoang Nguyen, MD","+84 983826797","dr.nguyenhoangphuc@ump.edu.vn",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Nguyen Hoang Phuc","Medical Doctor, Principal Investigator, Department of Ophthalmology","100589264","comparison-of-phaco-surgery-with-goniosynechialysis-versus-trabeculectomy-in-glaucoma-treatment-100589264",false,"NCT06952153","Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment","Comparison of Phaco Surgery and Goniosynechialysis Versus Trabeculectomy Outcomes in Glaucoma Patients","Inclusion Criteria:\n\n* Age ≥ 40 years\n* Peripheral anterior synechiae (PAS) \\>180°\n* Glaucomatous optic neuropathy with visual field loss\n* Intraocular pressure (IOP) \\> 21 mmHg despite medication\n* Ability to consent and comply with follow-up\n* Cataract grade 1 to 3 according to LOCS III\n* Best corrected visual acuity (BCVA) ≥ 0.3 logMAR (equivalent to 20\u002F40 Snellen or worse)\n\nExclusion Criteria:\n\n* Very advanced glaucoma (only light perception vision)\n* Secondary angle-closure etiologies\n* Prior ocular surgeries or laser peripheral iridotomy (PI)\n* Allergy to 5-fluorouracil (5-FU), if used postoperatively\n* Irreversible corneal disease\n* Chronic corticosteroid use\n* Poor follow-up compliance\n* Cataract grade 4 or 5 (LOCS III)\n* Phacomorphic, phacolytic, or subluxated cataracts","ALL","40 Years",{"count":68,"type":69},82,"ESTIMATED","INTERVENTIONAL",[72],"NA","The goal of this clinical trial is to learn whether phacoemulsification combined with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy in treating patients with primary angle-closure glaucoma.\n\nThe main questions it aims to answer are:\n\n* Does Phaco-GSL provide similar or better intraocular pressure (IOP) control compared to trabeculectomy?\n* What are the rates of postoperative complications or adverse events between the two surgical approaches?\n* How do the two procedures compare in terms of visual acuity recovery and need for glaucoma medications?\n\nResearchers will compare Phaco-GSL to trabeculectomy to determine which procedure offers better overall outcomes for patients with angle-closure glaucoma.\n\nParticipants will:\n\nBe randomly assigned to undergo either Phaco-GSL or trabeculectomy Attend scheduled follow-up visits at regular intervals (e.g., 1 week, 1 month, 3 months, 6 months, 12 months) for eye exams and pressure checks",[75],"Primary Angle Closure Glaucoma",[77,25,78,79,80],"PACG","trabeculectomy","RCT","Ophthalmic surgery","2025-09-04",{"date":83,"type":84},"2025-09-11","ACTUAL",{"date":86,"type":84},"2025-06-01",{"date":88,"type":69},"2027-09-10",{"name":5,"class":6},1]