[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578854":3},{"organization":4,"armGroups":7,"interventions":34,"overallOfficials":53,"centralContacts":57,"locations":66,"responsibleParty":84,"collaborators":39,"id":88,"slug":89,"hasResults":90,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":39,"eligibilityCriteria":94,"healthyVolunteers":90,"sex":95,"minAge":96,"maxAge":39,"enrollmentInfo":97,"targetDuration":39,"studyType":100,"phases":101,"briefSummary":103,"conditions":104,"keywords":108,"overallStatus":69,"whyStopped":39,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Capital Medical University","OTHER",[8,14,19,24,29],{"label":9,"type":10,"description":11,"interventionNames":12},"Modified high flow tracheal oxygen-40L\u002Fmin","EXPERIMENTAL","Modified high-flow tracheal oxygen with a flow rate of 40L\u002Fmin will be performed in mechanically ventilated patients undergoing spontaneous breathing trials.",[13],"Procedure: Modified high flow tracheal oxygen-40L\u002Fmin",{"label":15,"type":10,"description":16,"interventionNames":17},"Standard high flow tracheal oxygen-40L\u002Fmin","Standard high-flow tracheal oxygen with a flow rate of 40L\u002Fmin will be performed in mechanically ventilated patients undergoing spontaneous breathing trials.",[18],"Procedure: Standard high flow tracheal oxygen-40L\u002Fmin",{"label":20,"type":10,"description":21,"interventionNames":22},"T-piece","T-piece will be performed in mechanically ventilated patients undergoing spontaneous breathing trials.",[23],"Procedure: T-piece",{"label":25,"type":10,"description":26,"interventionNames":27},"Modified high-flow tracheal oxygen-60L\u002Fmin","Modified high-flow tracheal oxygen with a flow rate of 60L\u002Fmin will be performed in mechanically ventilated patients undergoing spontaneous breathing trials.",[28],"Procedure: Modified high-flow tracheal oxygen-60L\u002Fmin",{"label":30,"type":10,"description":31,"interventionNames":32},"Standard high-flow tracheal oxygen-60L\u002Fmin","Standard high-flow tracheal oxygen with a flow rate of 60L\u002Fmin will be performed in mechanically ventilated patients undergoing spontaneous breathing trials.",[33],"Procedure: Standard high-flow tracheal oxygen-60 L\u002Fmin",[35,40,43,46,49],{"type":36,"name":9,"description":37,"armGroupLabels":38,"otherNames":39},"PROCEDURE","Modified high-flow tracheal oxygen with a flow rate of 40L\u002Fmin will be performed.",[9],null,{"type":36,"name":15,"description":41,"armGroupLabels":42,"otherNames":39},"Standard high-flow tracheal oxygen with a flow rate of 40 L\u002Fmin will be performed.",[15],{"type":36,"name":20,"description":44,"armGroupLabels":45,"otherNames":39},"T-piece will be performed.",[20],{"type":36,"name":25,"description":47,"armGroupLabels":48,"otherNames":39},"Modified high-flow tracheal oxygen with a flow rate of 60L\u002Fmin will be performed.",[25],{"type":36,"name":50,"description":51,"armGroupLabels":52,"otherNames":39},"Standard high-flow tracheal oxygen-60 L\u002Fmin","Standard high-flow tracheal oxygen with a flow rate of 60 L\u002Fmin will be performed.",[30],[54],{"name":55,"affiliation":5,"role":56},"Jian-Xin Zhou, MD, PhD","PRINCIPAL_INVESTIGATOR",[58,62],{"name":55,"role":59,"phone":60,"phoneExt":39,"email":61},"CONTACT","8610 6392 6666","zhoujx.cn@icloud.com",{"name":63,"role":59,"phone":64,"phoneExt":39,"email":65},"Shan-Shan Xu, MD","8618501219133","1004496285@qq.com",[67],{"facility":68,"status":69,"city":70,"state":71,"zip":72,"country":73,"countryCode":74,"cosmosGeoPoint":75,"geoPoint":80,"contacts":81},"Beijing Shijitan Hospital","RECRUITING","Beijing","Beijing Municipality","100038","China","CN",{"type":76,"coordinates":77},"Point",[78,79],116.39723,39.9075,{"lat":79,"lon":78},[82,83],{"name":55,"role":59,"phone":60,"phoneExt":39,"email":61},{"name":63,"role":59,"phone":64,"phoneExt":39,"email":65},{"type":85,"investigatorFullName":86,"investigatorTitle":87,"investigatorAffiliation":5,"oldNameTitle":39,"oldOrganization":39},"SPONSOR_INVESTIGATOR","Jian-Xin Zhou","Professor","100578854","comparison-of-physiological-effects-of-two-high-flow-tracheal-oxygen-versus-t-piece-during-spontaneous-breathing-trials-100578854",false,"NCT06816706","Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials","Comparison of Physiological Effects of Two Types of High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials in Mechanically Ventilated Patients","Inclusion Criteria:\n\n1. Mechanical ventilation for more than 24 hours\n2. Considered by the physicians for the readiness to wean and ready for spontaneous breathing trials\n\nExclusion Criteria:\n\n1. Age younger than 18 years old\n2. Pregnancy\n3. Hemodynamic instability (mean arterial pressure \\\u003C60 mmHg, heart rate \\>140 or \\\u003C60 bpm)\n4. Respiratory and oxygenation instability (respiratory rate \\> 35bpm or oxygen saturation measured by pulse oximetry \\\u003C90%)\n5. Neuromuscular diseases or phrenic nerve injury\n6. Recent trauma or surgery to the trachea, esophagus, neck, chest, or stomach\n7. Pneumothorax or placement of a chest drainage\n8. Contraindication to electrical impedance tomography (EIT) (implantable defibrillator)\n9. Anticipating withdrawal of life support","ALL","18 Years",{"count":98,"type":99},20,"ESTIMATED","INTERVENTIONAL",[102],"NA","Spontaneous breathing trials (SBT) are essential for assessing extubation tolerance, yet optimal approaches are debated. High-flow nasal oxygen offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function. While high-flow tracheal oxygen can also be used as an SBT method, it has reduced physiological effects due to bypassing the upper airway with a more open circuit. To enhance this limitation, investigators developed a modified high-flow tracheal oxygen tube with a smaller expiratory end diameter to increase expiratory resistance and airway pressure. This is a prospective randomized crossover study that aims to compare the physiological effects of standard and modified high-flow tracheal oxygen versus T-piece during SBT.",[105,106,107],"Critical Care","Oxygen Therapy","Mechanical Ventilation",[109,110,111],"high-flow tracheal oxygen","T piece","spontaneous breathing trial","2025-03-20",{"date":114,"type":115},"2025-03-21","ACTUAL",{"date":117,"type":115},"2025-03-01",{"date":119,"type":99},"2025-12-30",{"name":86,"class":6},1]