[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640184":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":62,"collaborators":24,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":24,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":24,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":90,"whyStopped":24,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Riphah International University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Right side LLLT + MOP, Left side MOP only","EXPERIMENTAL","Group A will undergo micro-osteoperforations on Left side and Microosteoperforations with Low Level Laser Therapy combined on Right side of the Maxillary Arch",[13,14],"Other: Micro-osteoperforation","Device: Low Level Laser Therapy and Micro-osteoperforations Combined",{"label":16,"type":10,"description":17,"interventionNames":18},"Right side MOP only, Left side LLLT + MOP","Group B will undergo micro-osteoperforations on Right side and Microosteoperforations with Low Level Laser Therapy combined on Leftside of the Maxillary Arch",[13,14],[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Micro-osteoperforation","MOPs will be performed using a sterile surgical instrument under local anesthesia, ensuring patient comfort during the procedure. Small perforations will be created in the alveolar bone adjacent to the tooth undergoing orthodontic movement along the long axis of the tooth with rule of 3, 3mm difference between three sites along the distal root of Canine. The intervention was repeated after 3 weeks interval for 9 weeks. GNI Mini Screws 1.8 x 8 mm",[9,16],null,{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":24},"DEVICE","Low Level Laser Therapy and Micro-osteoperforations Combined","Woodpecker LX16 Plus Diode Laser (976± 20nm) will be applied at 5W and Frequency of 10000 Hz for 8 seconds producing a total of 8J Energy.\n\nMOPs will be performed using a sterile surgical instrument under local anesthesia, ensuring patient comfort during the procedure. Small perforations will be created in the alveolar bone adjacent to the tooth undergoing orthodontic movement along the long axis of the tooth with rule of 3, 3mm difference between three sites along the distal root of Canine. The intervention was repeated after 3 weeks interval for 9 weeks. GNI Mini Screws 1.8 x 8 mm",[9,16],[31],{"name":32,"affiliation":5,"role":33},"Ulfat Bashir","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},"Imran Amjad, Phd","CONTACT","+923324390125","imran.amjad@riphah.edu.pk",[41],{"facility":42,"status":24,"city":43,"state":44,"zip":24,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Islamic International Dental Hospital","Islamabad","Punjab Province","Pakistan","PK",{"type":48,"coordinates":49},"Point",[50,51],74.4039,31.6047,{"lat":51,"lon":50},[54,58,60],{"name":55,"role":37,"phone":56,"phoneExt":24,"email":57},"Ulfat Bashir, FCPS, MPH","+923335118561","ulfat.bashir@riphah.edu.pk",{"name":59,"role":33,"phone":24,"phoneExt":24,"email":24},"Nauman Arshad, MDS",{"name":55,"role":61,"phone":24,"phoneExt":24,"email":24},"SUB_INVESTIGATOR",{"type":63,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100640184","comparison-of-rate-of-tooth-movement-between-mops-vs-mops--lllt-combined-100640184",false,"NCT07626580","Comparison of Rate of Tooth Movement Between MOPs vs MOPs & LLLT Combined","Comparison of Rate of Tooth Movement Between Micro-osteoperforations Versus Micro-osteoperforations and Low Level Laser Therapy Combined","Inclusion Criteria:\n\n* • Patients aged 12-30 years requiring fixed orthodontic treatment.\n\n  * Patients with Class I or mild-to-moderate Class II malocclusion requiring canine retraction.\n  * No history of previous orthodontic treatment.\n  * Patients with indications for the extraction of the first premolars on both sides of the maxilla.\n\nExclusion Criteria:\n\n* • Patients with systemic conditions affecting bone metabolism (e.g., osteoporosis, diabetes).\n\n  * Smokers and individuals with poor oral hygiene.\n  * Pregnant or lactating women.",true,"ALL","18 Years","30 Years",{"count":76,"type":77},33,"ESTIMATED","INTERVENTIONAL",[80],"NA","Orthodontic treatment is often prolonged, requiring years to achieve desirable outcomes. The prolonged duration of treatment increases the risk of complications such as root resorption, periodontal damage, and patient non-compliance.\n\nTo address these concerns, various methods have been explored to accelerate orthodontic tooth movement, including pharmacological agents, mechanical vibration, corticotomies, and minimally invasive techniques like Micro-Osteoperforations (MOPs) and Low-Level Laser Therapy (LLLT). Micro-Osteoperforations (MOPs) have gained popularity as a minimally invasive technique that enhances bone remodeling by inducing a localized inflammatory response, thereby accelerating tooth movement.\n\nStudies have shown that MOPs can effectively stimulate the expression of cytokines, increasing osteoclastic activity and facilitating rapid orthodontic tooth movement. However, the extent of its effectiveness varies among individuals, necessitating additional interventions to maximize efficiency. Low-Level Laser Therapy (LLLT), also known as photobiomodulation, is another promising adjunct in orthodontics. LLLT has been reported to enhance cellular activity, promote osteoblastic and osteoclastic function, and improve tissue healing, leading to accelerated tooth movement. Several studies suggest that LLLT alone can expedite orthodontic treatment, but its combination with MOPs has not been extensively explored.\n\nThis study aims to compare the rate of orthodontic tooth movement between MOPs alone and MOPs combined with LLLT. By evaluating these two techniques, this research seeks to determine whether LLLT enhances the effectiveness of MOPs in accelerating tooth movement. The findings of this study could provide valuable insights into optimizing orthodontic treatment duration while minimizing potential risks and discomfort for patients.",[83,84,85],"Orthodontic Tooth Movement","Low Level Laser Therapy","Canine Retraction",[84,87,88,85,89],"LLLT","Micro-Osteoperforations","Maxillary Scan","NOT_YET_RECRUITING","2026-06-01",{"date":93,"type":94},"2026-06-04","ACTUAL",{"date":96,"type":77},"2026-06",{"date":98,"type":77},"2026-12",{"name":5,"class":6},1]