[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571956":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":23,"centralContacts":27,"locations":12,"responsibleParty":37,"collaborators":12,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":42,"sex":48,"minAge":12,"maxAge":12,"enrollmentInfo":49,"targetDuration":12,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":65,"whyStopped":12,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":12},{"fullName":5,"class":6},"Assiut University","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Unrestricted kinematic alignment","EXPERIMENTAL","reproducing the constitutional tibiofemoral tridimensional alignment and knee laxity. It is almost a pure bone procedure with only exceptional collateral ligament release, which has been shown to reliably position knee components.",null,{"label":14,"type":10,"description":15,"interventionNames":12},"Restricted kinematic alignment","reproducing patient's constitutional knee anatomy within a safe range while avoiding extreme or pathological anatomies that have been demonstrated to exist.",[17],{"type":18,"name":19,"description":20,"armGroupLabels":12,"otherNames":21},"PROCEDURE","Total knee arthroplasty","Total knee arthroplasty (TKA) is a common orthopaedic surgery that involves replacing the articular surfaces (femoral condyles and tibial plateau) of the knee joint with smooth metal and highly cross-linked polyethylene plastic",[22],"Total knee replacement",[24],{"name":25,"affiliation":5,"role":26},"Sohibe A Ghietah, Specialist","PRINCIPAL_INVESTIGATOR",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":12,"email":32},"Yaser E Khalifa, Professor","CONTACT","+201005673622","yaserkhalifa@aun.edu.eg",{"name":34,"role":30,"phone":35,"phoneExt":12,"email":36},"Mohammad K Abdelnasser, Ass. Professor","+201002438664","Abdelnasser.m.k@aun.edu.eg",{"type":26,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Sohibe Abdulazeem Ghietah Hussein","Doctor","100571956","comparison-of-restricted-versus-unrestricted-kinematic-alignment-in-1ry-tka-100571956",false,"NCT06726993","Comparison of Restricted Versus Unrestricted Kinematic Alignment in 1ry TKA","Comparison of Restricted Kinematic Alignment Versus Unrestricted Kinematic Alignment in Primary Total Knee Arthroplasty:- Randomized Controlled Trial","rKA-KA-TKA","Inclusion Criteria:\n\n-Patients suffered from end stage knee osteoarthritis of grade four according to Kellgren-Lawrence classification in at least one of the three knee compartments, who have an osteoarthritic knees of varus Coronal Plane Alignment of the Knee classification\n\nExclusion Criteria:\n\n1. Any valgus malalignment of the knee joint.\n2. Malalignment more than 10° or less than 3° varus of knee joint.\n3. Ligamentous laxity of the affected knee (medial or lateral collateral ligaments)\n4. any tumors or secondary neoplasia diseases\n5. Knee joint infection\n6. severe cardiopulmonary dysfunction.","ALL",{"count":50,"type":51},80,"ESTIMATED","INTERVENTIONAL",[54],"NA","Knee osteoarthritis is a growing socioeconomic burden because of the ageing and obesity. By 2030, the majority of individuals undergoing knee arthroplasty in USA will be those younger than 65 years, with up to 1 million achieved annually.\n\nThe definitive treatment for knee joint degeneration is total knee arthroplasty.",[57,58],"Osteoarthritis (OA) of the Knee","Total Knee Anthroplasty",[19,60,22,61,14,62,63,64,9],"TKA","TKR","rKA","Kinematic alignment","KA","NOT_YET_RECRUITING","2024-12-16",{"date":68,"type":69},"2024-12-19","ACTUAL",{"date":71,"type":51},"2025-02-01",{"date":73,"type":51},"2027-06-01",{"name":5,"class":6}]