[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638221":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":14,"responsibleParty":26,"collaborators":7,"id":29,"slug":30,"hasResults":31,"nctId":32,"briefTitle":33,"officialTitle":34,"acronym":35,"eligibilityCriteria":36,"healthyVolunteers":31,"sex":37,"minAge":38,"maxAge":7,"enrollmentInfo":39,"targetDuration":42,"studyType":43,"phases":7,"briefSummary":44,"conditions":45,"keywords":48,"overallStatus":52,"whyStopped":7,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":62},{"fullName":5,"class":6},"Cukurova University","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Ghanim Khatib","CONTACT","+903223386060","ghanim.khatib@gmail.com",[15],{"facility":16,"status":7,"city":17,"state":7,"zip":18,"country":19,"countryCode":7,"cosmosGeoPoint":20,"geoPoint":25,"contacts":7},"Cukurova Univercity","Adana","01000","Turkey (Türkiye)",{"type":21,"coordinates":22},"Point",[23,24],35.32531,36.98615,{"lat":24,"lon":23},{"type":27,"investigatorFullName":10,"investigatorTitle":28,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","professor","100638221","comparison-of-sentinel-lymph-node-applications-in-endometrial-cancer-cases-performed-with-vaginal-natural-orifice-transluminal-endoscopic-surgery-v-notes-and-conventional-laparoscopy-100638221",false,"NCT07583329","Comparison of Sentinel Lymph Node Applications in Endometrial Cancer Cases Performed With Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) and Conventional Laparoscopy","Comparison of Sentinel Lymph Node Applications in Endometrial Cancer Cases Performed With V-NOTES and Conventional Laparoscopy: A Multicenter Prospective Observational Study","V-COSMOS","Inclusion Criteria:\n\n* Age ≥18 years\n* Histologically confirmed endometrial cancer on preoperative endometrial biopsy\n* Disease confirmed to be confined to the uterus based on clinical evaluation and imaging\n* No evidence of lymphatic or distant metastasis on positron emission tomography\u002Fcomputed tomography(PET\u002FCT) or magnetic resonance imaging (MRI)\n* Surgical staging with sentinel lymph node biopsy recommended by a multidisciplinary tumor board\n* Surgical treatment performed using either conventional laparoscopy or the vNOTES approach\n\nExclusion Criteria:\n\n* Presence of extrauterine disease\n* Detection of distant metastasis\n* Surgery performed via an open (laparotomy) approach\n* Incomplete medical records\n* History of prior pelvic radiotherapy","FEMALE","18 Years",{"count":40,"type":41},160,"ESTIMATED","10 Years","OBSERVATIONAL","Endometrial cancer is a common cancer in women, and surgery is usually the first step in treatment. During surgery, doctors often check nearby lymph nodes to see if the cancer has spread. A newer method called sentinel lymph node (SLN) mapping allows doctors to examine only the first few lymph nodes most likely to contain cancer. This can reduce the need for removing many lymph nodes and may lower the risk of complications.\n\nMinimally invasive surgery is commonly performed using small abdominal incisions (laparoscopy). A newer technique, called vaginal natural orifice transluminal endoscopic surgery (vNOTES), allows the surgery to be performed through the vagina without any cuts on the abdomen. This approach may lead to less pain, quicker recovery, and no visible scars.\n\nThis study will compare these two surgical methods-laparoscopy and vNOTES-in patients with early-stage endometrial cancer. Researchers will look at how safe and effective each method is, how patients recover after surgery, and how well the sentinel lymph node procedure works with each technique. The study will also examine how quickly surgeons become experienced with the newer vNOTES method.\n\nThe goal of this research is to determine whether vNOTES can be a safe and effective alternative to standard laparoscopic surgery, while offering potential benefits for patients.",[46,47],"Endometrial Adenocarcinoma","Endometrial Cancer",[49,50,51],"v-notes","sentinel lymph node","conventional laparoscopy","NOT_YET_RECRUITING","2026-05-18",{"date":55,"type":56},"2026-05-20","ACTUAL",{"date":58,"type":41},"2026-05-19",{"date":60,"type":41},"2036-04-30",{"name":5,"class":6},1]