[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605858":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":41,"responsibleParty":55,"collaborators":25,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":25,"eligibilityCriteria":63,"healthyVolunteers":60,"sex":64,"minAge":65,"maxAge":25,"enrollmentInfo":66,"targetDuration":25,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":77,"overallStatus":82,"whyStopped":25,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University of Health Sciences Lahore","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Talc Slurry Group","EXPERIMENTAL","patient undergoing pleurodesis by talc slurry method are included in this group",[13],"Procedure: Pleurodesis",{"label":15,"type":10,"description":16,"interventionNames":17},"Talc Insufflation Group","patient undergoing pleurodesis by talc insufflation method are included in this group",[18],"Procedure: pleurodesis",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Pleurodesis","Talc slurry pleurodesis is a chemical technique for managing recurrent pleural effusions and pneumothoraces. The procedure involves instilling a suspension of talc (4-5 grams) in sterile saline (50-100 mL) into the pleural space via a chest tube. This induces an inflammatory reaction, leading to fibrosis and fusion of pleural surfaces. The technique demonstrates 70-90% success rates in malignant pleural effusions and pneumothoraces, with efficacy comparable to talc poudrage. While generally safe, potential complications include pain, fever, and rarely, pneumonitis or empyema. Use of large-particle, asbestos-free talc and standardized protocols has improved its safety profile.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"pleurodesis","Talc insufflation, is a pleurodesis technique involving direct insufflation of dry talc powder into the pleural cavity during thoracoscopy. It allows visual inspection of the pleural space and concurrent diagnostic procedures. Success rates range from 85% to 93% for malignant pleural effusions and pneumothoraces, with efficacy comparable or potentially superior to talc slurry in some studies. The procedure typically requires general anesthesia and is more invasive than talc slurry. Common side effects include chest pain, fever, and dyspnea. The risk of severe respiratory complications has decreased with large-particle, asbestos-free talc. While effective, the choice between insufflation and slurry depends on patient factors, institutional expertise, and resource availability.",[15],[31],{"name":32,"affiliation":33,"role":34},"Muhammad Shoaib Nabi, Professor of Thoracic Surgery","Services institute of Medical Sciences (SIMS), Services Hospital Lahore","STUDY_CHAIR",[36],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Zeeshan Sarwar","CONTACT","+92 3214347410","zeeshan.sarwar195@gmail.com",[42],{"facility":43,"status":25,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":25},"Services Institute of Medical Sciences (SIMS), Services Hospital Lahore","Lahore","Punjab Province","54000","Pakistan","PK",{"type":50,"coordinates":51},"Point",[52,53],74.35071,31.558,{"lat":53,"lon":52},{"type":56,"investigatorFullName":37,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100605858","comparison-of-talc-slurry-versus-talc-insufflation-a-study-on-effectiveness-safety-and-hospital-outcomes-in-pleurodesis-100605858",false,"NCT07167992","Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis","Inclusion Criteria:\n\n* patients aged 12 years and older.\n* Diagnosed with malignant pleural effusions or pneumothoraces.\n* ECOG performance status of 0-2.\n* Life expectancy of at least 3 months.\n* Ability to provide informed consent.\n* No contraindications to general anesthesia or conscious sedation.\n\nExclusion Criteria:\n\n* Patients younger than 12 years old\n* Female patients who are pregnant or lactating\n* Patients with encysted or septated pleural effusions and pneumothoraces\n* Patients presenting with respiratory failure\n* Patients complaining of dyspnea in spite of complete evacuation of pleural effusion or pneumothorax.\n* Patients with evident chest infection with clinical or laboratory signs suggestive of parapneumonic effusions.","ALL","12 Years",{"count":67,"type":68},160,"ESTIMATED","INTERVENTIONAL",[71],"NA","Pleural effusion is characterized by the accumulation of fluid in the pleural space, which typically contains about 10-20 mL of pleural fluid that is crucial for the movement of the lungs against the chest wall. This fluid closely resembles plasma but has a lower protein concentration, usually less than 1.5 gm\u002FdL. It primarily originates from pleural capillaries and the interstitial spaces of the lung, and is reabsorbed through the lymphatic vessels in the parietal pleura, either via small openings known as stomas or through a process called transcytosis (1, 2). When the balance between fluid production and reabsorption is disrupted-often due to various pathogenic mechanisms-it can lead to pleural effusion. In such cases, effective management is essential. This study aims to conduct a thorough comparison of the two talc administration methods-TS and TI-using sterilized, large-particle, asbestos-free talc powder. By examining key outcome measures such as pleurodesis success rates, procedural morbidity, and length of hospital stay, the goal is to provide clinicians with evidence-based guidance to facilitate informed decision-making in the management of pleural effusions.",[74,75,76,22],"Pneumothorax Spontaneous Primary","Pneumothorax Spontaneous Secondary","Pleural Effusion, Malignant",[78,79,22,80,81],"Talc slurry","Talc Insufflation","malignant pleural effusions","recurrent pneumothorax","NOT_YET_RECRUITING","2026-01-03",{"date":85,"type":86},"2026-01-06","ACTUAL",{"date":88,"type":68},"2026-02-01",{"date":90,"type":68},"2027-03-30",{"name":5,"class":6},1]