[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632704":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":25,"responsibleParty":40,"collaborators":10,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":10,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":10,"enrollmentInfo":52,"targetDuration":10,"studyType":55,"phases":10,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":67,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Ankara Ataturk Sanatorium Training and Research Hospital","OTHER_GOV",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Desflurane+Remifentanyl Group",null,"Desflurane+Remifentanyl Group: Patients who receive remifentanil and desflurane during anesthesia",{"label":13,"type":10,"description":14,"interventionNames":10},"Propofol + Remifentanyl Group","Propofol + Remifentanyl Group: Patients who receive remifentanyl and propofol during anesthesia",[16],{"name":17,"affiliation":5,"role":18},"Hilal Sazak, Prof. Dr","PRINCIPAL_INVESTIGATOR",[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"ELİF ECE REIS, MD","CONTACT","+90 552 716 15 28","eer_933@hotmail.com",[26],{"facility":27,"status":10,"city":28,"state":28,"zip":29,"country":30,"countryCode":10,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Ankara Atatürk Sanatorium Training and Research Hospital","Ankara","06010","Turkey (Türkiye)",{"type":32,"coordinates":33},"Point",[34,35],32.85427,39.91987,{"lat":35,"lon":34},[38],{"name":39,"role":22,"phone":23,"phoneExt":10,"email":24},"Elif Ece Reis, MD",{"type":18,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Hilal GUNAL SAZAK","Professor of Anesthesiology","100632704","comparison-of-the-effects-of-desflurane-remifentanyl-and-propofol-remifentanyl-anesthesia-on-intraoperative-cerebral-oxygenation-in-patients-undergoing-laparoscopic-cholecystectomy-100632704",false,"NCT07517146","Comparison of the Effects of Desflurane-Remifentanyl and Propofol-Remifentanyl Anesthesia on Intraoperative Cerebral Oxygenation in Patients Undergoing Laparoscopic Cholecystectomy","Comparison of the Effects of Desflurane-Remifentanyl and Propofol-Remifentanyl Anesthesia on Intraoperative Cerebral Oxygenation and Postoperative Complications in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Those with ASA 1-2-3\n* Those who have undergone laparoscopic cholecystectomy\n* Those with BMI between 18-40 kg\u002Fm2\n\nExclusion Criteria:\n\n* Emergency surgeries\n* Individuals with neurological disorders, diseases, or drug (opioid or sedative) use that affect cognitive function\n* Individuals who do not speak Turkish\n* Individuals who have received general anesthesia within the last 7 days\n* Individuals with severe organ dysfunction\n* Individuals allergic to the drugs used in the study","ALL","18 Years",{"count":53,"type":54},84,"ESTIMATED","OBSERVATIONAL","Study Population:\n\nPatients undergoing elective laparoscopic cholecystectomy under general anesthesia will be included.\n\nStudy Design:\n\nThis is an observational study. No interventions outside routine clinical practice will be applied. All procedures will be performed by experienced anesthesiologists according to standard institutional protocols.\n\nData Collection\n\nPreoperative Data:\n\nThe following variables will be recorded from anesthesia charts:\n\nDemographics: age, sex, height, weight, body mass index (BMI) Education level Smoking, alcohol, and substance use status Routine preoperative laboratory tests\n\nClinical scores:\n\nCharlson Comorbidity Index (CCI) Beck Anxiety Scale ARISCAT Score STOP-BANG Score Montreal Cognitive Assessment (MoCA) ASA Physical Status Classification\n\nIntraoperative Data:\n\nPatients will be observed in two groups based on anesthesia technique:\n\nDesflurane + remifentanyl Total intravenous anesthesia (TIVA: propofol + remifentanyl)\n\nThe following parameters will be recorded:\n\nHemodynamic data: blood pressure, heart rate Oxygenation parameters: SpO₂, SpO₂\u002FFiO₂ ratio Cerebral and depth monitoring: NIRS, BIS Respiratory mechanics Oxygen Saturation Index (OSI = \\[Pmean × FiO₂\\] \u002F SpO₂) Mechanical ventilator parameters\n\nTime Points for Measurement:\n\nBefore induction After induction After intubation Every 20 minutes intraoperatively After extubation\n\nAdditional Intraoperative Variables:\n\nDuration of surgery and anesthesia\n\nTotal anesthetic drug consumption:\n\nDesflurane and remifentanyl Propofol and remifentanyl (TIVA group) Intraoperative blood transfusion (yes\u002Fno) Total blood loss Urine output Recovery time Postoperative Follow-up ICU admission (planned or unplanned)\n\nPain assessment using Numeric Rating Scale (NRS):\n\nPACU Postoperative 1st, 3rd, 6th, 12th, and 24th hours\n\nPostoperative Complications:\n\nNausea and vomiting Hypotension Arrhythmia (bradycardia, tachycardia) Pulmonary edema Atelectasis Pneumonia Pneumothorax Pleural effusion Cognitive dysfunction\n\nOther Outcomes:\n\nPostoperative MoCA and Beck Anxiety Scale scores Length of hospital stay Length of ICU stay (if applicable) Mortality during follow-up",[58,59],"ıntraoperative Cerebral Oxygenation","Cerebral Oxygenation Monitoring",[61,62,63,64,65,66],"NIRS","BIS Monitoring","Laparoscopic Cholecystectomy","desflurane","remifentanil","propofol","NOT_YET_RECRUITING","2026-04-01",{"date":70,"type":71},"2026-04-08","ACTUAL",{"date":73,"type":54},"2026-04-06",{"date":75,"type":54},"2026-09",{"name":5,"class":6},1]