[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100645075":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":37,"locations":47,"responsibleParty":68,"collaborators":71,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":42,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":42,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":97,"overallStatus":50,"whyStopped":42,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"University of Gaziantep","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Sevoflurane General Anesthesia (SGA)","ACTIVE_COMPARATOR","Participants in this group will receive sevoflurane general anesthesia according to standard institutional protocols for kidney transplantation.",[13],"Procedure: Sevoflurane General Anesthesia",{"label":15,"type":10,"description":16,"interventionNames":17},"Combined Spinal-Epidural Anesthesia (CSEA)","Participants in this group will receive combined spinal-epidural anesthesia as the anesthetic technique for kidney transplantation.",[18],"Procedure: Combined Spinal-Epidural Anesthesia",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Sevoflurane General Anesthesia","Participants will receive standardized sevoflurane general anesthesia according to institutional kidney transplantation protocols. Anesthesia induction will include preoxygenation with 100% oxygen for 3-5 minutes, followed by intravenous propofol (1.5-2.5 mg\u002Fkg), fentanyl (1-2 µg\u002Fkg), and rocuronium bromide (0.6 mg\u002Fkg). Endotracheal intubation will be performed after short mask ventilation using direct laryngoscopy, and correct placement will be confirmed by auscultation. Anesthesia maintenance will be provided with sevoflurane (1.5-2.0% end-tidal) in a 40-50% oxygen\u002Fair mixture and remifentanil infusion (0.05-0.2 µg\u002Fkg\u002Fmin). Mechanical ventilation will be set to 6-8 mL\u002Fkg tidal volume, PEEP 5 cmH₂O, and end-tidal CO₂ 35-40 mmHg. At the end of surgery, sevoflurane will be discontinued, neuromuscular blockade will be reversed with sugammadex (2-4 mg\u002Fkg), and extubation will be performed after recovery. Postoperative analgesia will include subcutaneous morphine (0.1 mg\u002Fkg).",[9],[26],"Sevoflurane anesthesia",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Combined Spinal-Epidural Anesthesia","Participants will receive combined spinal-epidural anesthesia under sterile conditions according to institutional protocols. The L3-L4 interspace will be identified, and local anesthesia will be administered with lidocaine (2-3 mL, 2%). A Tuohy needle will be inserted using a midline approach, and the epidural space will be identified using loss-of-resistance technique. Spinal anesthesia will be achieved via intrathecal injection of 2.5 mL of 0.5% hyperbaric bupivacaine after confirmation of cerebrospinal fluid flow. An epidural catheter will then be placed and secured. Sedation will be provided with intravenous midazolam (1-2 mg), and oxygen will be administered via nasal cannula (4 L\u002Fmin). Intraoperative analgesia will be maintained with epidural 0.25% bupivacaine as needed. At the end of surgery, epidural morphine (3 mg) combined with 0.25% bupivacaine will be administered for postoperative analgesia.",[15],[32],"CSE anesthesia",[34],{"name":35,"affiliation":5,"role":36},"Berna KAYA UĞUR, Doç. Dr.","PRINCIPAL_INVESTIGATOR",[38,44],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Abdulkadir UÇAR, MD","CONTACT","+90 534 030 89 56",null,"drkadirucar@gmail.com",{"name":35,"role":40,"phone":45,"phoneExt":42,"email":46},"+90 532 572 76 51","bernakayaugur@hotmail.com",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":42,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Gaziantep University Faculty of Medicine Hospital","RECRUITING","Gaziantep","State\u002FProvince","27310","Turkey (Türkiye)",{"type":56,"coordinates":57},"Point",[58,59],37.3825,37.05944,{"lat":59,"lon":58},[62,64,65,66],{"name":63,"role":40,"phone":41,"phoneExt":42,"email":43},"Abdulkadir Uçar, MD",{"name":35,"role":40,"phone":45,"phoneExt":42,"email":43},{"name":35,"role":36,"phone":42,"phoneExt":42,"email":42},{"name":63,"role":67,"phone":42,"phoneExt":42,"email":42},"SUB_INVESTIGATOR",{"type":36,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"Berna Kaya Ugur","Doç. Dr.",[72],{"name":73,"class":6},"The Scientific and Technological Research Council of Turkey","100645075","comparison-of-the-effects-of-general-anesthesia-and-combined-spinal-epidural-anesthesia-on-ferroptosis-humanin-and-mots-c-levels-in-renal-transplantation-100645075",false,"NCT07678073","COMPARISON OF THE EFFECTS OF GENERAL ANESTHESIA AND COMBINED SPINAL-EPIDURAL ANESTHESIA ON FERROPTOSIS, HUMANIN, AND MOTS-C LEVELS IN RENAL TRANSPLANTATION","COMPARISON OF THE EFFECTS OF GENERAL ANESTHESIA AND COMBINED SPINAL-EPIDURAL ANESTHESIA ON FERROPTOSIS, HUMANIN, AND MOTS-C LEVELS IN RENAL TRANSPLANTATION: A PROSPECTIVE CONTROLLED STUDY","Inclusion Criteria:\n\n* Patients aged 18-70 years with American Society of Anesthesiologists (ASA) physical status I-III.\n* Patients scheduled for elective living-donor allogeneic kidney transplantation.\n* Patients receiving sevoflurane-based general anesthesia as the anesthetic technique.\n* Patients receiving combined spinal-epidural anesthesia as the anesthetic technique.\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 70 years.\n* Patients undergoing deceased-donor kidney transplantation.\n* Patients receiving total intravenous anesthesia (TIVA).\n* Patients who decline to participate in the study or are unable to provide informed consent.\n* Patients with American Society of Anesthesiologists (ASA) physical status IV or V.\n* Patients with a history of previous organ transplantation.\n* Patients with known or suspected mitochondrial disorders.\n* Patients with a history of chronic corticosteroid use.\n* Patients requiring red blood cell transfusion intraoperatively or within the first 24 postoperative hours.\n* Patients with a primary warm ischemia time \\>5 minutes, secondary warm ischemia time \\>30 minutes, or cold ischemia time \\>60 minutes.","ALL","18 Years","70 Years",{"count":85,"type":86},68,"ESTIMATED","INTERVENTIONAL",[89],"NA","Renal transplantation is the most effective renal replacement therapy for patients with end-stage renal disease. Ischemia-reperfusion injury may adversely affect graft function and long-term outcomes. Ferroptosis has recently emerged as a potential mechanism involved in ischemia-reperfusion injury, while the mitochondrial-derived peptides humanin and MOTS-c are thought to exert protective effects against oxidative stress. However, the effects of different anesthetic techniques on these biomarkers in kidney transplant recipients have not been investigated.\n\nThis prospective controlled study aims to compare the effects of sevoflurane general anesthesia (SGA) and combined spinal-epidural anesthesia (CSEA) on serum ferroptosis markers, humanin, and MOTS-c levels in adult kidney transplant recipients. Blood samples will be obtained perioperatively for biomarker analysis.\n\nThe primary objective of the study is to evaluate the effects of the anesthetic technique on serum ferroptosis markers, humanin, and MOTS-c levels. Secondary objectives include evaluating early graft function and postoperative outcomes by assessing the incidence of delayed graft function, postoperative serum creatinine levels, requirement for dialysis, urine output, length of hospital stay, and the association of these outcomes with perioperative biomarker levels.",[92,93,94,95,96],"Kidney Disease, End-Stage","Kidney Transplant","Kidney","Kidney Disease","Renal Transplant",[98,99,100,101,102,103,104,105,106],"GENERAL ANESTHESIA","REGIONAL ANESTHESIA","KIDNEY TRANSPLANTATION","CELLULAR STRESS RESPONSE","CELLULAR STRESS","ANESTHESIA","HUMANIN","MOTS-c","FERROPTOSIS","2026-06-24",{"date":109,"type":110},"2026-07-01","ACTUAL",{"date":112,"type":110},"2026-03-01",{"date":114,"type":86},"2026-10-15",{"name":5,"class":6},1]