[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640952":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":52,"collaborators":54,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":24,"eligibilityCriteria":62,"healthyVolunteers":59,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":24,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":77,"whyStopped":24,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"King Edward Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Preoperative Calcium and Vitamin D3 Supplementation","ACTIVE_COMPARATOR","Participants in this arm will receive oral calcium carbonate (500-1000 mg, two to three times daily) along with oral vitamin D3 (cholecalciferol 1000-2000 IU once daily) for 7 days prior to total thyroidectomy. This supplementation is given to assess its effectiveness in reducing postoperative symptomatic hypocalcemia compared to calcium alone.",[13],"Drug: Calcium carbonate plus vitamin D3 (cholecalciferol)",{"label":15,"type":10,"description":16,"interventionNames":17},"Participants in this arm will receive oral calcium carbonate (500-1000 mg, two to three times daily)","Participants in this arm will receive oral calcium carbonate (500-1000 mg, two to three times daily) for 7 days prior to total thyroidectomy without vitamin D3 supplementation. This group serves as the control to compare the incidence of postoperative symptomatic hypocalcemia.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Calcium carbonate plus vitamin D3 (cholecalciferol)","Participants in this arm will receive oral calcium carbonate (500-1000 mg, two to three times daily) in combination with oral vitamin D3 (cholecalciferol 1000-2000 IU once daily) for 7 days prior to total thyroidectomy. This preoperative supplementation is administered to evaluate its effectiveness in reducing the incidence of postoperative symptomatic hypocalcemia.",[15,9],null,[26],{"name":27,"affiliation":28,"role":29},"Ahmad Rauf, MBBS","KEMU","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":24,"email":35},"Ali Raza, MBBS","CONTACT","+923406600052","dralirazasial777@gmail.com",{"name":27,"role":33,"phone":37,"phoneExt":24,"email":38},"+923006023465","ahmadrauf498@gmail.com",[40],{"facility":5,"status":24,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":24},"Lahore","Punjab Province","54000","Pakistan","PK",{"type":47,"coordinates":48},"Point",[49,50],74.35071,31.558,{"lat":50,"lon":49},{"type":53,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[55],{"name":56,"class":6},"Mayo Hospital Lahore","100640952","comparison-of-the-efficacy-between-preoperative-calcium--vitamin-d3-versus-calcium-supplementation-alone-to-prevent-post-operative-symptomatic-hypocalcemia-after-total-thyroidectomy-in-euthyroid-patients-100640952",false,"NCT07597096","COMPARISON OF THE EFFICACY BETWEEN PREOPERATIVE CALCIUM & VITAMIN D3 VERSUS CALCIUM SUPPLEMENTATION ALONE TO PREVENT POST OPERATIVE SYMPTOMATIC HYPOCALCEMIA AFTER TOTAL THYROIDECTOMY IN EUTHYROID PATIENTS","Inclusion Criteria:\n\n* A) Age between 18 to 60 years B) Both genders C) Multiple nodular goiter diagnosed on the basis of history and investigation like thyroid function test , USG neck for TIRADS scoring and USG guided FNAC to confirm the diagnosis .\n\nD) ASA grade 1 \\&2 E) With preserved one or two parathyroid gland\n\nExclusion Criteria:\n\n* A) Cardiovascular disease B) Deranged Renal parameters C) Pregnancy D) Concomitant endocrine pathology warranting the surgery","ALL","18 Years","75 Years",{"count":67,"type":68},124,"ESTIMATED","INTERVENTIONAL",[71],"NA","Total thyroidectomy is a commonly performed surgery for thyroid diseases such as multinodular goiter. One of the most frequent complications after this procedure is hypocalcemia (low blood calcium levels), which may cause symptoms such as tingling around the mouth, muscle cramps, and in severe cases, spasms or confusion. This condition usually occurs within the first 24-72 hours after surgery and may delay hospital discharge and increase patient discomfort.\n\nThis study aims to compare the effectiveness of preoperative calcium plus vitamin D3 supplementation versus calcium supplementation alone in preventing postoperative symptomatic hypocalcemia in patients undergoing total thyroidectomy. Patients diagnosed with multinodular goiter and planned for surgery will be randomly assigned into two groups. One group will receive calcium with vitamin D3 for seven days before surgery, while the other group will receive calcium alone for the same duration.\n\nAfter surgery, patients will be monitored for symptoms of hypocalcemia and their serum calcium levels will be checked at 6, 24, and 48 hours, as well as at a follow-up visit on day 14. The main outcome of the study is the occurrence of symptomatic hypocalcemia in both groups.\n\nThe results of this study may help determine whether adding vitamin D3 to preoperative calcium supplementation provides better protection against hypocalcemia after thyroid surgery, potentially improving patient outcomes and reducing hospital stay.",[74],"Postoperative Symptomatic Hypocalcemia Following Total Thyroidectomy",[76],"Total thyroidectomy Postoperative hypocalcemia Symptomatic hypocalcemia Calcium supplementation Vitamin D3 (cholecalciferol) Preoperative supplementation","NOT_YET_RECRUITING","2026-05-13",{"date":80,"type":81},"2026-05-19","ACTUAL",{"date":83,"type":68},"2026-05-10",{"date":85,"type":68},"2026-06-30",{"name":5,"class":6},1]