[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613274":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":59,"collaborators":40,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":40,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":40,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":86,"overallStatus":47,"whyStopped":40,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Ataturk University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Itbs","ACTIVE_COMPARATOR","iTBS with eight digit coils to the left dorsolateral prefrontal cortex.",[13],"Device: Transcranial Magnetic Stimulation with figure-eight coil",{"label":15,"type":10,"description":16,"interventionNames":17},"ctbs","cTBS with a figure-of-eight coil to the right dorsolateral prefrontal cortex.",[13],[19,26],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","Transcranial Magnetic Stimulation with figure-eight coil","A total of 50 sessions will be administered to at least 30 patients, five sessions per day, five days a week for two weeks. There will be at least a 30-minute rest period between each session. One session for Group A involves a 5 Hz frequency intermittent theta burst stimulation (iTBS) protocol applied to the left DLPFC at 90-110% motor threshold.",[9],[25],"A group",{"type":20,"name":21,"description":27,"armGroupLabels":28,"otherNames":29},"The other patient group (Group B), consisting of at least 30 individuals, will receive 5 sessions per day, 5 days a week, for 2 weeks, for a total of 50 sessions. There will be at least a 30-minute rest period between each session. Group B will receive a 5 Hz, continuous theta burst stimulation (cTBS) protocol to the right DLPFC at 80% motor threshold.",[15],[30],"B group",[32],{"name":33,"affiliation":5,"role":34},"Omer Faruk UYGUR, Associate professor doctor","PRINCIPAL_INVESTIGATOR",[36,42],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Mahmut Balamur, research assistant doctor","CONTACT","+905350705623",null,"m.balamur5@gmail.com",{"name":33,"role":38,"phone":43,"phoneExt":40,"email":44},"+905456161625","drofuygur@hotmail.com",[46],{"facility":5,"status":47,"city":48,"state":40,"zip":49,"country":50,"countryCode":40,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Erzurum","25240","Turkey (Türkiye)",{"type":52,"coordinates":53},"Point",[54,55],41.27694,39.90861,{"lat":55,"lon":54},[58],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},{"type":34,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":40,"oldOrganization":40},"Omer Faruk Uygur","associate professor","100613274","comparison-of-the-efficacy-of-accelerated-intermittent-theta-burst-stimulation-and-accelerated-continuous-theta-burst-stimulation-in-patients-with-treatment-resistant-depression-100613274",false,"NCT07264452","Comparison of the Efficacy of Accelerated Intermittent Theta Burst Stimulation and Accelerated Continuous Theta Burst Stimulation in Patients With Treatment-Resistant Depression","Inclusion Criteria:\n\n1. 18 to 65 years old\n2. Patients diagnosed with Major Depressive Disorder according to DSM 5 and the severity of their illness\n3. Scoring 7 points or more on the Maudsley staging method\n4. Having depression unresponsive to 2 different antidepressants\n5. No clinical mental retardation\n6. Agree to participate in the study\n7. Hamilton Depression Rating Scale-17 \\[HDRS\\] score of 20 or higher\n8. Montgomery Asberg Depression Rating Scale \\[MADRS\\] score of 20 or above\n9. Being right hand dominant\n10. Having used the same antidepressant at the same dose for the last 4 weeks\n\nExclusion Criteria:\n\n1. Diagnosed with a neurological or metabolic disease that affects cognitive functions (Systemic diseases such as diabetes mellitus, cardiovascular disease, cerebrovascular disease, chronic renal failure, Parkinson's disease, multiple sclerosis, polyneuropathy, inflammatory rheumatologic disease and malignancies)\n2. Having a foreign body such as a pacemaker, intracranial implant that can magnetically interact\n3. Hearing and visual impairments that prevent communication\n4. Unstable or acute medical conditions\n5. Pregnancy or breastfeeding\n6. Having a primary psychiatric disorder other than major depressive disorder\n7. Being diagnosed with severe MDD with psychotic features",true,"ALL","18 Years","65 Years",{"count":73,"type":74},60,"ESTIMATED","INTERVENTIONAL",[77],"NA","In recent years, research on the effectiveness of transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (RTD) has been steadily increasing. The aim of this study was to examine the effectiveness of accelerated unilateral application of two different forms of theta burst stimulation (TBU), a variation of repetitive TMU (rTMS)-intermittent TBU (iTBU) and continuous TBU (cTBU)-in TDD patients. The study aimed to compare the advantages of iTBU and cTBU protocols on depression, suicidal thoughts, anxiety levels, sleep disturbances, cognitive performance, and overall functioning following a two-week intensive treatment period and a 12-week follow-up period.",[80,81,82,83,84,85],"Treatment Resistant Depression (TRD)","Transcranial Magnetic Stimulation","Accelerated Protocol","Intermittent Theta Burst Stimulation","Continuous Theta Burst Stimulation","Unilateral rTMS",[80,81,87,88,89,85,90,91],"Accelerated protocol","intermittent theta burst stimulation","Continuous theta burst stimulation","unipolar major depressive disorder","non-invasive brain stimulation","2025-12-02",{"date":94,"type":95},"2025-12-04","ACTUAL",{"date":97,"type":95},"2025-11-15",{"date":99,"type":74},"2027-01-15",{"name":5,"class":6},1]