[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553888":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":49,"collaborators":25,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":25,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":25,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":25,"overallStatus":70,"whyStopped":25,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"RESnTEC, Institute of Research","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Losartan group","EXPERIMENTAL","Patients will receive Losartan (LS) 50 mg per day.",[13],"Drug: Losartan",{"label":15,"type":10,"description":16,"interventionNames":17},"Losartan + Hydrochlorothiazide","Patients will be given losartan LS (50 mg per day) and Hydrochlorothiazide (HCTZ) 12.5 mg per day as a combination therapy.",[18],"Drug: Losartan + Hydrochlorothiazide",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Losartan","Patients will receives Losartan (LS) 50 mg per day.",[9],null,{"type":21,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Patients will be given Losartan LS (50 mg per day) and Hydrochlorothiazide (HCTZ) 12.5 mg per day as a combination therapy.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Muhammad Wasim Zahid","CONTACT","03336361025","drwasimzahid@gmail.com",[36],{"facility":37,"status":25,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":25},"Medical department, Bahawal Victoria Hospital","Bahawalpur","Punjab Province","06318","Pakistan","PK",{"type":44,"coordinates":45},"Point",[46,47],71.6752,29.39779,{"lat":47,"lon":46},{"type":50,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100553888","comparison-of-the-role-of-losartan-alone-vs-hydrochlorothiazide-plus-losartan-100553888",false,"NCT06491940","Comparison of the Role of Losartan Alone vs Hydrochlorothiazide Plus Losartan","Comparison of the Role of Losartan Alone vs Hydrochlorothiazide Plus Losartan on Proteinuria in Diabetic Nephropathy Patients","Inclusion Criteria:\n\n* Patients of both genders with ≥18 years of age.\n* Presence of proteinuria\u002Falbuminuria at time of screening.\n* Creatinine clearance of 30 mL\u002Fmin or higher.\n\nExclusion Criteria:\n\n* A systolic blood pressure of 180 mm Hg or higher, a diastolic blood pressure of 110 mm Hg or higher.\n* Presence of a second primary renal disease in addition to diabetic nephropathy.\n* Patients with type 1 diabetes.\n* A history of a cardiovascular or cerebrovascular event within 3 months before inclusion.\n* Serum potassium of 6.0 mmol\u002FL or higher.\n* Transplantation or immunosuppressive treatment.\n* Contraindication for the use of losartan or hydrochlorothiazide.\n* Pregnancy or lactation.","ALL","18 Years","75 Years",{"count":62,"type":63},234,"ESTIMATED","INTERVENTIONAL",[66],"NA","Losartan, an angiotensin II receptor blocker, has already been established as a treatment for diabetic nephropathy due to its ability to reduce blood pressure and mitigate the progression of kidney damage. However, the addition of a diuretic like hydrochlorothiazide may offer synergistic benefits in reducing proteinuria by addressing both the underlying renal pathology and potential volume overload in these patients. The current study aims at determining and comparing the role of losartan alone vs hydrochlorothiazide plus losartan in reducing proteinuria in diabetic nephropathy patients.",[69],"Proteinuria","NOT_YET_RECRUITING","2024-07-01",{"date":73,"type":74},"2024-07-09","ACTUAL",{"date":76,"type":63},"2024-08-01",{"date":78,"type":63},"2025-07-31",{"name":5,"class":6},1]