[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100534398":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":35,"responsibleParty":54,"collaborators":57,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":20,"enrollmentInfo":71,"targetDuration":20,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":38,"whyStopped":20,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Sahlgrenska University Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients in the intensive care unit and outpatients with acute or chronic kidney insufficiency","EXPERIMENTAL","Measuring glomerular filtration rate (GFR) with two different marker and the same measuring protocol.",[13],"Diagnostic Test: Comparison of two external marker substance for measuring glomerular filtration rate",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIAGNOSTIC_TEST","Comparison of two external marker substance for measuring glomerular filtration rate","Two external marker substance compares for measuring GFR.",[9],null,[22],{"name":23,"affiliation":24,"role":25},"Gudrun Bragadottir, MD, PhD","Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden","STUDY_DIRECTOR",[27,32],{"name":28,"role":29,"phone":30,"phoneExt":20,"email":31},"Katalin Kiss","CONTACT","+46761285184","katalin_kiss@icloud.com",{"name":23,"role":29,"phone":33,"phoneExt":20,"email":34},"+46313427453","gudrun.bragadottir@vgregion.se",[36],{"facility":37,"status":38,"city":39,"state":20,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"SahlgrenskaUH","RECRUITING","Gothenburg","41345","Sweden","SE",{"type":44,"coordinates":45},"Point",[46,47],11.96679,57.70716,{"lat":47,"lon":46},[50,52],{"name":51,"role":29,"phone":30,"phoneExt":20,"email":31},"Katalin Kiss, MD",{"name":53,"role":29,"phone":33,"phoneExt":20,"email":34},"Gudrun Bragadottir, PhD",{"type":55,"investigatorFullName":28,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"SPONSOR_INVESTIGATOR","consultant anesthesiologist",[58],{"name":59,"class":6},"Göteborg University","100534398","comparison-of-two-different-external-clearance-markers---mannitol-and-iohexol-for-measuring-glomerular-filtration-rate-100534398",false,"NCT06238310","Comparison of Two Different External Clearance Markers - Mannitol and Iohexol for Measuring Glomerular Filtration Rate","Comparison of Two Different External Clearance Markers for Measuring Glomerular Filtration Rate (GFR) - Mannitol and Iohexol, in Patients Treated in the Intensive Care Units and in Outpatients With Chronic Kidney Disease.","GFR","Inclusion Criteria:\n\n* Patients with acute or acute on chronic kidney failure (AKI, CKD) on intensive care units because of any kind of organ insufficiency.\n* Stabile circulatory parameters.\n* CKD-patients in outpatient group\n\nExclusion Criteria:\n\n* unstable circulation with need for fluid resuscitation.\n* known extracellular volume expansion as ascites or peripheral edema.\n* Intravenous paracetamol administration between or during the measurement period.\n* measurement with iohexol during the previous days.\n* missing inform consent.",true,"ALL","18 Years",{"count":72,"type":73},40,"ESTIMATED","INTERVENTIONAL",[76],"NA","GFR is the best parameter of the real kidney function. Measurements, however are time-consuming and have limited capacity.\n\nPatients treated in the intensive care units often have more than one organ-insufficiency and acute kidney injury (AKI) has an incidence of up to 70 %. GFR changes dynamically and this is one of the reasons why GFR-measurements have limited indications on the ICU. Retention of medicines or their active metabolites, however can lead to side effects, toxicity and or prolonged ICU-stay. Moreover, patients with allergy to actually standard marker, contrast material iohexol, or gravid patients are not candidate for measuring GFR with iohexol.\n\nIn this prospective clinical trial two exogen marker substances will be compared, mannitol as a new marker and iohexol as a standard marker for measuring glomerular filtration rate (GFR). Patients in the intensive care units (ICU) and an outpatient group with stable chronic kidney disease (CKD) are included.\n\nThe main question is, how reliable mannitol-GFR is compared to iohexol-GFR in a wide range of kidney insufficiency.\n\nGFR measurements are performed with a bolus injection technique. Patients get mannitol and iohexol bolus at time zero and blood samples are taken three times according to local protocols for iohexol clearance measurements.",[79,80],"Acute Kidney Injury","Chronic Kidney Insufficiency",[82],"Glomerular Filtration Rate","2024-06-24",{"date":85,"type":86},"2024-06-26","ACTUAL",{"date":88,"type":86},"2023-08-01",{"date":90,"type":73},"2025-04-01",{"name":28,"class":6},1]