[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593202":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":12,"centralContacts":24,"locations":12,"responsibleParty":30,"collaborators":12,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":12,"eligibilityCriteria":40,"healthyVolunteers":41,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":12,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":58,"whyStopped":12,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":12},{"fullName":5,"class":6},"Mashhad University of Medical Sciences","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"natural cycle group","NO_INTERVENTION","A transvaginal ultrasound is performed on cycle day 2 or 3 to rule out ovarian cysts and confirm an endometrial thickness \\\u003C5 mm. If eligible, patients are monitored from day 8 onward. Ovulation is tracked by assessing dominant follicle growth (≥15 mm), LH surge (≥17 IU\u002FL), and serum progesterone (\\>1.5 ng\u002FmL). Once ovulation is confirmed and endometrial thickness reaches ≥7 mm, FET is scheduled for 6 days post-LH surge or 5 days post-follicle collapse. Serum progesterone is measured one day before transfer; if \\\u003C10 ng\u002FmL, 400 mg\u002Fday progesterone is administered",null,{"label":14,"type":15,"description":12,"interventionNames":16},"Hormone Replacement Therapy (HRT)","EXPERIMENTAL",[17],"Drug: hormone replacement therapy (HRT) group",[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":12},"DRUG","hormone replacement therapy (HRT) group","Estradiol valerate is initiated at 4 mg\u002Fday on day 2 of the menstrual cycle and is adjusted to 8 mg\u002Fday based on endometrial thickness. Once the endometrial thickness reaches ≥8 mm, progesterone supplementation is started (400 mg vaginal suppositories twice daily and 50 mg intramuscular injections daily) for 5 days before blastocyst transfer.",[14],[25],{"name":26,"role":27,"phone":28,"phoneExt":12,"email":29},"Malihe Mahmoudinia, Prof","CONTACT","09153047813","mahmoudiniam@mums.ac.ir",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"SPONSOR_INVESTIGATOR","Malihe Mahmoudinia","Associate Professor of obstetrics & Gynecology, Fellowship of infertility, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran","100593202","comparison-of-two-protocols-in-frozen-embryo-transfer-100593202",false,"NCT07003373","Comparison of Two Protocols in Frozen Embryo Transfer","Comparison of the Pregnancy Outcomes of Frozen Embryo Transfer in the Natural Cycle vs. Artificial Cycle","Inclusion Criteria:\n\nRegular menstrual cycles\n\nMaternal age between 18 and 42 years\n\nNormal intrauterine cavity confirmed by pretreatment ultrasound or hysteroscopy\n\nBody Mass Index (BMI) less than 30 kg\u002Fm²\n\nNo ovulation disorders\n\nExclusion Criteria:\n\nNo embryos available for transfer (no embryo thawing)\n\nWithdrawal of patient consent to continue treatment\n\nFailure of dominant follicle development (in natural cycle group)\n\nInadequate endometrial response for transfer\n\nNo endometriosis grade 3 or higher\n\nThe participant provided written informed consent",true,"FEMALE","18 Years","42 Years",{"count":46,"type":47},112,"ESTIMATED","INTERVENTIONAL",[50],"NA","This randomized clinical trial evaluates two different endometrial preparation protocols-hormone replacement therapy (HRT) and natural cycle-for frozen embryo transfer (FET) in infertile women undergoing assisted reproductive technology (ART). The goal is to compare implantation, clinical pregnancy, and ongoing pregnancy outcomes.",[53],"IVF Outcomes",[55,56,57],"Natural cycle","Artificial cycle","Frozen embryo transfer","NOT_YET_RECRUITING","2025-05-25",{"date":61,"type":62},"2025-06-04","ACTUAL",{"date":64,"type":47},"2025-07-05",{"date":66,"type":47},"2026-07-05",{"name":32,"class":6}]