[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628316":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":62,"collaborators":26,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":26,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":91,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Hayatabad Medical Complex","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patient receiving Propofol infusion for controlled hypotention during surgery under general anaes","EXPERIMENTAL","Intravenous propfol infusion (starting 12mg\u002Fkg\u002Fhr) adminitration intraoperatively as sedative for controlled hypotension during endoscopic sinus surgery",[13],"Drug: Propofol",{"label":15,"type":16,"description":17,"interventionNames":18},"Isoflurane inhalation for controlled hypotension during surgery under general anaesthesia","ACTIVE_COMPARATOR","Isoflurane inhalation (1-2% end tidal) given intraoperativley as sedative for controlled hypotension during eendoscopic sinus surgery",[19],"Drug: Isoflurane",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Propofol","Intravenous propofol infusion (starting dose 12mg\u002Fkg\u002Fhr and titrated accordingly) given to patients as sedative undergoing endscopic sinus surgery for hemodynamic stability",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Isoflurane","Isoflurane inhalation (1-2% end tidal) used in patients as sedative undergoing endoscopic sinus surgery for hemodynamic stability",[15],[32],{"name":33,"affiliation":34,"role":35},"Dr. Laiba Khalid, Postgraduate trainee","Hayat Abad Medical Complex, Peshawar","STUDY_CHAIR",[37,43],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},"Dr. Laiba Khalid, Trainee Medical Officer","CONTACT","+923320031941","0915824091","kgmcite15@gmail.com",{"name":38,"role":39,"phone":44,"phoneExt":40,"email":42},"03320031941",[46],{"facility":47,"status":26,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Hayatabad Medical Complex, Peshawar","Peshawar","Khyber Pakhtunkhwa","25000","Pakistan","PK",{"type":54,"coordinates":55},"Point",[56,57],71.57849,34.008,{"lat":57,"lon":56},[60],{"name":61,"role":39,"phone":44,"phoneExt":26,"email":42},"Laiba Khalid, Trainee Medical Officer",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Amina Sultan","Assistant professor","100628316","comparison-of-two-sedative-agents-in-terms-of-controlled-hypotension-100628316",false,"NCT07460050","Comparison of Two Sedative Agents in Terms of Controlled Hypotension","COMPARISON OF PROPOFOL INFUSION VS INHALATIONAL AGENT ISOFLURANE IN TERMS OF CONTROLLED HYPOTENSION IN PATIENTS UNDERGOING ENDOSCOPIC SINUS SURGERY","Inclusion Criteria:\n\n* Either male\u002Ffemale Age 18-65 Patients undergoing endoscopic sinus surgery as per the operational definition\n\nExclusion Criteria:\n\n* Patients with cardiovascular disease Patients with pregnancy Patients with coagulopathy Patients on beta blockers or calcium channel blockers",true,"ALL","18 Years","65 Years",{"count":78,"type":79},136,"ESTIMATED","INTERVENTIONAL",[82],"NA","Propofol and Isoflurane are commonly used sedative agents in general anaesthesia.Both these drugs have a side effect of decreasing blood pressure which when used optimally can be used to acheive controlled hypotention. So, it provides a better visiblity of surgical filed to the surgeons.This RCT compares propofol infusion vs isoflurane inhalation for inducing controlled hypotension during endoscopic sinus surgery. The goal is to assess which agent better controls blood pressure, improves surgical field visibility, and impacts recovery. It likely measures outcomes like hemodynamics, bleeding, and surgeon satisfaction.",[85],"Controlled Hypotension for Nasal Surgeries",[87,88,89,90],"Controlled hypotention","Propofol infusion","Endoscopic sinus surgery","Isoflurane inhalation","NOT_YET_RECRUITING","2026-03-04",{"date":94,"type":95},"2026-03-10","ACTUAL",{"date":97,"type":79},"2026-03-01",{"date":99,"type":79},"2026-08-01",{"name":5,"class":6},1]