[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636796":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":31,"centralContacts":35,"locations":26,"responsibleParty":44,"collaborators":26,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":26,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":79,"whyStopped":26,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":26},{"fullName":5,"class":6},"ART Fertility Clinics LLC","OTHER",[8,13,18],{"label":9,"type":6,"description":10,"interventionNames":11},"Group 1: Oocyte Activation (OA) CultActive","Oocytes are cultured immediately after injection in a pre-calibrated OA-CultActive dish for 15 min in CO2 incubator, then injected oocytes are rinsed well in culture dish\u002F Embryoscope slide in GT-culture medium. Then transferred to the numbered droplet or well.",[12],"Other: Group 1: Oocyte Activation (OA) CultActive",{"label":14,"type":6,"description":15,"interventionNames":16},"Group 2: Oocyte Activation (OA) Ionomycin","Oocytes are placed immediately after injection in a pre-calibrated OA-Ionomycin dish (dish 1) for 7 - 10 min in CO2 incubator, then they are rinsed well and placed in another culture dish (dish 2) for 25 min in CO2 incubator. Then MIIs are exposed again in OA-Ionomycin dish for 10 min, then they are rinsed well and placed into culture dish\u002F Embryoscope slide in GT-culture medium. Then transferred to the numbered droplet or well.",[17],"Other: Group 2: Oocyte Activation (OA) Ionomycin",{"label":19,"type":6,"description":20,"interventionNames":21},"Group 3: Control","Oocytes are cultured as per routine practice after injection in culture dish\u002F Embryoscope slide in routine culture GT-culture medium.",[22],"Other: Group 3: Control",[24,27,29],{"type":6,"name":9,"description":10,"armGroupLabels":25,"otherNames":26},[9],null,{"type":6,"name":14,"description":15,"armGroupLabels":28,"otherNames":26},[14],{"type":6,"name":19,"description":20,"armGroupLabels":30,"otherNames":26},[19],[32],{"name":33,"affiliation":5,"role":34},"BARBARA LAWRENZ","STUDY_DIRECTOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"JONALYN EDADES, EMBA Healthcare Management","CONTACT","026528000","jonalyn.edades@artfertilityclinics.com",{"name":42,"role":38,"phone":39,"phoneExt":26,"email":43},"barbara lawrenz, PhD","barbara.lawrenz@artfertilityclinics.com",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Noreen","Embryologist","100636796","comparison-of-two-types-of-calcium-ca-ionophore-treatments-for-oocyte-activation-in-cases-of-suboptimal-fertilization-potential-100636796",false,"NCT07570342","Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential","(Ca²⁺)","Inclusion Criteria:\n\n1. Patients undergoing assisted reproductive technology cycles when ICSI is indicated.\n2. Patients with a minimum of 3 MII oocytes after denudation.\n3. Maternal age 18-43 years old.\n4. PGT-A cycles with only trophectoderm biopsies on day 5\u002F6\u002F7.\n5. BMI\\\u003C35.\n6. Fresh and frozen immotile ejaculated sperm.\n7. Fresh and frozen TESE sperm (motile and immotile).\n8. Globozoospermia.\n\n10\\. Couples undergoing ICSI due to poor fertilization history (≤30%), or previous fertilization failure.\n\nExclusion Criteria:\n\n1. PGT-M\u002FSR cycles.\n2. Fresh and frozen motile ejaculated \u002F FNA sperm.\n3. IVF inseminated oocytes.",true,"FEMALE","18 Years","43 Years",{"count":60,"type":61},20,"ESTIMATED","INTERVENTIONAL",[64],"NA","This study aims to investigate the effectiveness and safety of assisted oocyte activation (AOA) using Ca²⁺ ionophores in cases of total fertilization failure (TFF) due to oocyte activation deficiency (OAD). The study will be conducted in two phases: Phase I will compare the fertilization rates of oocytes exposed to two types of Ca²⁺ ionophore treatments- Ionomycin solution and commercially available CultActive-against a control group without calcium ionophore treatment. Phase II will assess whether an additional injection of CaCl2, prior to exposure to the chosen ionophore from Phase I, further improves fertilization outcomes. The goal is to identify the optimal AOA protocol for improving fertilization rates and to evaluate the safety and efficacy of this approach in relation to ploidy, with a focus on ensuring normal pre-implantation embryo development.",[67,68,69,70],"ICSI","Testicular Sperm Extraction in Azoospermic Patients","Male Infertility","PGT-A",[67,70,72,73,74,75,76,77,78],"artificial oocyte activation","AOA","calcium ionophore","ionomycin","TESE","Immotile sperm","Failed fertilization","NOT_YET_RECRUITING","2026-05-06",{"date":82,"type":83},"2026-05-11","ACTUAL",{"date":85,"type":61},"2026-04-30",{"date":87,"type":61},"2026-12-31",{"name":5,"class":6}]