[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100460660":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":33,"locations":38,"responsibleParty":81,"collaborators":84,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":10,"studyType":104,"phases":10,"briefSummary":105,"conditions":106,"keywords":109,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"University of Turku","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"OA cases",null,"Fifty adult patients who have hip osteoarthritis.",[13],"Procedure: Total hip arthroplasty",{"label":15,"type":10,"description":16,"interventionNames":17},"RA cases","Forty adult patients who have rheumatoid arthritis in the hip joint.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Non-arthritic controls","Twenty adult patients who go through trauma-based emergency total hip arthroplasty and do not have arthritis.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"PROCEDURE","Total hip arthroplasty","Hip joint replacement surgery. Elective for RA and OA cases.",[19,9,15],[29],{"name":30,"affiliation":31,"role":32},"Lea Mikkola, PhD","Turku Bioscience, University of Turku","PRINCIPAL_INVESTIGATOR",[34],{"name":30,"role":35,"phone":36,"phoneExt":10,"email":37},"CONTACT","+358404143300","limikk@utu.fi",[39,52,56,67],{"facility":40,"status":41,"city":42,"state":43,"zip":10,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":10},"PET-centre, University of Turku","ACTIVE_NOT_RECRUITING","Turku","Southwest Finland","Finland","FI",{"type":47,"coordinates":48},"Point",[49,50],22.26869,60.45148,{"lat":50,"lon":49},{"facility":31,"status":41,"city":42,"state":43,"zip":10,"country":44,"countryCode":45,"cosmosGeoPoint":53,"geoPoint":55,"contacts":10},{"type":47,"coordinates":54},[49,50],{"lat":50,"lon":49},{"facility":57,"status":58,"city":42,"state":43,"zip":10,"country":44,"countryCode":45,"cosmosGeoPoint":59,"geoPoint":61,"contacts":62},"Turku University Hospital","RECRUITING",{"type":47,"coordinates":60},[49,50],{"lat":50,"lon":49},[63,66],{"name":64,"role":35,"phone":10,"phoneExt":10,"email":65},"Pjotr Sarantsin, MD","Pjotr.Sarantsin@tyks.fi",{"name":64,"role":32,"phone":10,"phoneExt":10,"email":10},{"facility":68,"status":58,"city":69,"state":70,"zip":10,"country":44,"countryCode":45,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Helsinki University Hospital","Espoo","Uusimaa",{"type":47,"coordinates":72},[73,74],24.6522,60.2052,{"lat":74,"lon":73},[77,80],{"name":78,"role":35,"phone":10,"phoneExt":10,"email":79},"Anna Vasara, MD, PhD","anna.vasara@hus.fi",{"name":78,"role":32,"phone":10,"phoneExt":10,"email":10},{"type":32,"investigatorFullName":82,"investigatorTitle":83,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Lea Mikkola","Principal Investigator",[85,87],{"name":57,"class":86},"OTHER_GOV",{"name":88,"class":6},"Hospital District of Helsinki and Uusimaa","100460660","complex-molecular-etiology-and-cellular-landscape-of-hip-osteoarthritis-100460660",false,"NCT05278520","Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis","Studies on the Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis","OASEQ","Inclusion Criteria for the main (OA) study:\n\nCases: Adult patients with osteoarthritis in the hip joint and who are going through an elective total hip arthroplasty.\n\nControls: Non-arthritis adult patients who are going through a trauma-based emergency total hip arthroplasty.\n\n\\----\n\nInclusion Criteria for the Rheumatoid sub-study:\n\nAdult patients with rheumatoid arthritis in the hip joint and who are going through an elective total hip arthroplasty.\n\n\\----\n\nExclusion Criteria:\n\n* The body mass index must be below 35\n* Age \\\u003C 18 or \\> 74\n* The OA patients may not have diabetes, rheumatoid arthritis (RA), or metabolic syndrome.\n\nFor the Rheumatoid sub-study, the exclusion criteria are the same as above except for the RA.",true,"ALL","18 Years","74 Years",{"count":102,"type":103},110,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to cast light on the highly complex etiology and cellular landscape of hip osteoarthritis by utilising single-cell and spatial omics.",[107,108],"Osteoarthritis, Hip","Rheumatoid Arthritis",[110,111,112,113,114],"Single-cell RNA sequencing","Spatial transcriptomics","Osteoarthritis","Rheumatoid arthritis","Spatial proteomics","2025-08-18",{"date":117,"type":118},"2025-08-24","ACTUAL",{"date":120,"type":118},"2023-01-11",{"date":122,"type":103},"2028-12",{"name":5,"class":6},4]