[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625423":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":34,"locations":39,"responsibleParty":41,"collaborators":43,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":39,"enrollmentInfo":56,"targetDuration":39,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":76,"whyStopped":39,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":82,"leadSponsor":84,"locationsCount":39},{"fullName":5,"class":6},"Swissmed Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Compliance-Guided Closure Strategy","EXPERIMENTAL","Participants undergo elective large ventral hernia repair after preoperative botulinum toxin A preparation. During surgery, a predefined intraoperative decision strategy is applied during abdominal wall closure using standardized measurements of static respiratory system compliance (Cstat) at predefined timepoints (baseline after intubation before incision, during closure as the decision point, and before extubation). Standardized ventilation settings are used during measurements (volume-controlled ventilation, tidal volume 6 mL\u002Fkg ideal body weight, PEEP 10 cmH2O) with full neuromuscular blockade. A closure is considered physiologically tolerable when Cstat remains at least 70 percent of baseline; if Cstat decreases below this threshold during closure, the surgical team considers avoiding tension closure and may use a bridging or alternative closure approach according to clinical judgment. When intra-abdominal pressure is measured as part of routine care, values are recorded.",[13],"Other: Compliance-Guided Abdominal Wall Closure Decision Strategy",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Compliance-Guided Abdominal Wall Closure Decision Strategy","A predefined intraoperative decision strategy that uses standardized measurements of static respiratory system compliance (Cstat) during abdominal wall closure to support selection of closure technique, with a predefined physiological tolerance threshold based on the baseline measurement.",[9],[20,21,22],"Static Compliance-Guided Closure Algorithm","Cstat-Guided Closure Strategy","Physiology-Guided Abdominal Wall Closure",[24,28,31],{"name":25,"affiliation":26,"role":27},"Irmina Anna Śmietański, MD, PhD","Śmietański Hernia Center, LUX MED Hospital in Gdańsk","PRINCIPAL_INVESTIGATOR",{"name":29,"affiliation":26,"role":30},"Maciej Śmietański, Prof.","STUDY_CHAIR",{"name":32,"affiliation":26,"role":33},"Mateusz Zamkowski, MD, PhD","STUDY_DIRECTOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Magdalena Halska","CONTACT","607870690",null,"worldofsurge@gmail.com",{"type":42,"investigatorFullName":39,"investigatorTitle":39,"investigatorAffiliation":39,"oldNameTitle":39,"oldOrganization":39},"SPONSOR",[44],{"name":45,"class":6},"Medical University of Gdansk","100625423","compliance-guided-abdominal-wall-closure-strategy-in-large-ventral-hernia-repair-100625423",false,"NCT07422441","Compliance-Guided Abdominal Wall Closure Strategy in Large Ventral Hernia Repair","Impact of a Compliance-Guided Intraoperative Abdominal Wall Closure Decision Strategy on Early Postoperative Respiratory Failure After Large Ventral Hernia Repair Following Preoperative Botulinum Toxin A","CLOSE-STAT","Inclusion Criteria:\n\n* Age 18 years or older\n* Elective repair of a large ventral abdominal wall hernia (including incisional hernia)\n* Preoperative botulinum toxin A preparation performed as part of the local prehabilitation pathway\n* Preoperative abdominal CT available\n* General anesthesia with mechanical ventilation and feasibility of standardized intraoperative respiratory mechanics measurements\n\nExclusion Criteria:\n\n* Severe preoperative respiratory failure judged to preclude standardized intraoperative respiratory mechanics assessment\n* Inability to obtain reliable static respiratory system compliance measurements at predefined timepoints\n* Hemodynamic instability preventing protocolized measurements (as judged by the anesthesiologist)","ALL","18 Years",{"count":57,"type":58},50,"ESTIMATED","INTERVENTIONAL",[61],"NA","People undergoing repair of large ventral hernias can develop breathing problems after surgery, especially around the time when the abdominal wall is closed. During closure, pressure inside the abdomen may increase and lung mechanics can worsen. This study will evaluate a structured intraoperative decision approach that uses standard anesthesia measurements of static respiratory system compliance at predefined timepoints to support the choice of abdominal wall closure technique. The main goal is to assess the rate of early postoperative respiratory failure within 72 hours after surgery.",[64,65,66,67],"Hernia, Ventral","Hernia Incisional","Postoperative Complications","Respiratory Insufficiency",[69,70,71,72,73,74,75],"adbominal wall closure","static compliance","respiratory system compliance","intraoperative monitoring","intra-abdominal pressure","complex hernia repair","botulinum toxin a","NOT_YET_RECRUITING","2026-02-12",{"date":79,"type":80},"2026-02-20","ACTUAL",{"date":79,"type":58},{"date":83,"type":58},"2026-11-01",{"name":5,"class":6}]