[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606137":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":27,"locations":10,"responsibleParty":33,"collaborators":37,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":10,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":10,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":10,"overallStatus":56,"whyStopped":10,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":10},{"fullName":5,"class":6},"Ramos Mejía Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Survivors",null,"Survivors patients \\> 18 years on the third day of ARDS receiving invasive mechanical ventilation (volume control mode) for at least 48 consecutive hours.",[13],"Other: monitoring of clinical and ventilatory variables",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"monitoring of clinical and ventilatory variables","Monitoring clinical data",[9],[20,24],{"name":21,"affiliation":22,"role":23},"Martin Angulo, PhD","Hospital de Clínicas \"Dr. Manuel Quintela\" Faculty of Medicine, Universidad de la República (Udelar) Montevideo, Uruguay","STUDY_CHAIR",{"name":25,"affiliation":22,"role":26},"Antonella Gómez, MD","STUDY_DIRECTOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Roberto Santa Cruz, PhD","CONTACT","+5492966559019","resc.hrrg@gmail.com",{"type":34,"investigatorFullName":35,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Roberto Santa Cruz","PhD",[38],{"name":39,"class":6},"Universidad de la Republica","100606137","components-of-mechanical-power-on-the-functional-lung-in-ards-100606137",false,"NCT07171632","Components of Mechanical Power on the Functional Lung in ARDS","Assessment of Mechanical Power Components on the Functional Lung in Patients With Acute Respiratory Distress Syndrome (ARDS)","Inclusion Criteria:\n\n* Patients ≥ 18 years\n* Diagnosis of acute respiratory distress syndrome\n* Receiving invasive mechanical ventilation (volume control mode) for at least 48 consecutive hours.\n\nExclusion Criteria:\n\n* Patients spontaneously breathing\n* Patients under non-invasive support therapies\n* Patients receiving ventilation through a tracheostomy cannula at any time during the first 48 h\n* Patients that receiving pressure-controlled ventilation or any modality other than volume-controlled\n* Patients with missing data for calculating mechanical power (MP).\n* Patients with chronic pulmonary disease\n* Patients with a high risk of death within 3 months for reasons other than ARDS\n* Patients having made the decision to withhold life-sustaining treatment.","ALL","18 Years",{"count":50,"type":51},184,"ESTIMATED","OBSERVATIONAL","Mechanical power (MP) is a composite variable that integrates static and dynamic respiratory parameters and has been associated with ventilator-induced lung injury (VILI). MP is predominantly delivered to the reduced functional lung size, commonly referred to as the \"baby lung\" (BL). Functional lung size, in turn, is closely related to respiratory system compliance (Crs). Previous studies have demonstrated an association between MP normalized to compliance (MP\u002FCrs) and mortality. Moreover, evidence suggests that VILI associated with MP\u002FCrs results primarily from the combined effect of its components rather than from any single component in isolation.\n\nThe objective of this study is to evaluate both the overall and the relative contribution of each component of mechanical power, normalized to compliance (MP\u002FCrs), to in-hospital mortality in patients with acute respiratory distress syndrome (ARDS).",[55],"Respiratory Distress Syndrome (RDS)","NOT_YET_RECRUITING","2025-11-26",{"date":59,"type":60},"2025-12-04","ACTUAL",{"date":62,"type":51},"2025-12-01",{"date":64,"type":51},"2027-03-10",{"name":5,"class":6}]