[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100271846":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":29,"responsibleParty":45,"collaborators":11,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":11,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":31,"whyStopped":11,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Centre Hospitalier Universitaire, Amiens","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Composite tissue allotransplantation","EXPERIMENTAL",null,[13],"Procedure: composite tissue allotransplantation",[15],{"type":16,"name":17,"description":11,"armGroupLabels":18,"otherNames":11},"PROCEDURE","composite tissue allotransplantation",[9],[20],{"name":21,"affiliation":22,"role":23},"Bernard DEVAUCHELLE, Md, PhD","CHU Amiens","PRINCIPAL_INVESTIGATOR",[25],{"name":21,"role":26,"phone":27,"phoneExt":11,"email":28},"CONTACT","+33 3 22 08 90 71","devauchelle.bernard@chu-amiens.fr",[30],{"facility":22,"status":31,"city":32,"state":11,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Amiens","80054","France","FR",{"type":37,"coordinates":38},"Point",[39,40],2.3,49.9,{"lat":40,"lon":39},[43],{"name":44,"role":26,"phone":27,"phoneExt":11,"email":28},"Bernard DEVAUCHELLE, MD, PhD",{"type":46,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100271846","composite-tissue-allotransplantation-of-the-face-anatomical-and-functional-evaluation-100271846",false,"NCT02818400","Composite Tissue Allotransplantation of the Face: Anatomical and Functional Evaluation","AFTC","Inclusion Criteria:\n\n* Patients with loss of unrepairable substance by conventional techniques shreds, at the front\n\nExclusion Criteria:\n\n* Facial lesions repaired by conventional reconstructive surgery techniques\n* History of malignancy in remission for less than 5 years\n* Malignant neoplasm undergoing changes\n* Severe psychiatric history\n* Patients above a score of 2 on the scale of the ASA (American Society of Anesthesiology)\n* Patients above a grade 1 in the classification NYHA ( New York Heart Association )\n* insufficient with renal creatinine clearance less than 70 mL \u002F min or presence of a proteinuria\n* Severe hypertension","ALL","18 Years","50 Years",{"count":58,"type":59},5,"ESTIMATED","INTERVENTIONAL",[62],"NA","In hindsight, the first \"face graft\" raises the fundamental problem of composite tissue allotransplantation (hand, larynx, abdominal wall, etc.) with the addition of specific technical and philosophical problems.\n\nBy proposing a prospective study concerning five new patients over the next three years, in the light of this first experience, the authors would like to confirm the surgical feasibility of this type of procedure, possibly extending it to other parts of the face (lateral third) and, like English and American teams, considering the possibility of total facial surface reconstruction.\n\nIn parallel, and while complying with the usual immunosuppression procedures, the deliberate choice of creating a microchimerism by the infusion of bone marrow stem cells (the origin and quantity of which will need to be determined) will be reaffirmed, in order to improve mucocutaneous tissue tolerance, while confirming the safety of this type of approach.\n\nFive new cases will also provide observations for the many new fields of research developing around composite tissue transplants (neurophysiology, skin histopathology, psychiatry, haematology, immunology, etc.).",[65],"Surgery, Oral",[67,68,69,70,71,72],"maxillofacial surgery","face graft","composite tissue","stem cell infusion","allotransplantation","microsurgery","2026-05-12",{"date":75,"type":76},"2026-05-13","ACTUAL",{"date":78,"type":76},"2009-11",{"date":80,"type":59},"2026-12",{"name":5,"class":6},1]