[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621009":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":41,"responsibleParty":63,"collaborators":25,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":25,"eligibilityCriteria":70,"healthyVolunteers":67,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":91,"whyStopped":25,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"University Hospital Ostrava","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Extraoesophageal reflux","EXPERIMENTAL","Patients with extraoesophageal reflux will be enrolled in this study arm.",[13,14],"Diagnostic Test: High resolution oesophageal manometry with impedance","Diagnostic Test: 24-hour pH metry",{"label":16,"type":10,"description":17,"interventionNames":18},"Dysphagia","Patients with dysphagia reflux will be enrolled in this study arm.",[13],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","High resolution oesophageal manometry with impedance","Patients with extraoesophageal reflux and dysphagia will undergo high resolution oesophageal manometry with impedance.",[16,9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"24-hour pH metry","Patients with extraoesophageal reflux will undergo 24-hour pH-metry.",[9],[31],{"name":32,"affiliation":5,"role":33},"Dominik Tichý, MD","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Jiří Hynčica","CONTACT","+42059737","2587","jiri.hyncica@fno.cz",[42],{"facility":5,"status":25,"city":43,"state":44,"zip":45,"country":46,"countryCode":25,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Ostrava","Moravian-Silesian Region","70852","Czechia",{"type":48,"coordinates":49},"Point",[50,51],18.28204,49.83465,{"lat":51,"lon":50},[54,55,56,59,61],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},{"name":32,"role":33,"phone":25,"phoneExt":25,"email":25},{"name":57,"role":58,"phone":25,"phoneExt":25,"email":25},"Karol Zeleník, prof., MD, PhD, MBA","SUB_INVESTIGATOR",{"name":60,"role":58,"phone":25,"phoneExt":25,"email":25},"Viktória Hránková, MD, PhD",{"name":62,"role":58,"phone":25,"phoneExt":25,"email":25},"Patrícia Gubová, MD",{"type":64,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100621009","comprehensive-analysis-of-the-swallowing-mechanism-using-high-resolution-manometry-with-impedance-100621009",false,"NCT07365046","Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With Impedance","Inclusion Criteria:\n\n* age 18-75 years\n* patients with swallowing difficulties suspected of having a functional oesophageal disorder or patients with clinical signs of extra-oesophageal reflux (Reflux Symptom Index \\[RSI\\] ≥ 13 or Reflux Symptom Score-12 \\[RSS-12\\] ≥ 11) signed informed consent\n\nExclusion Criteria:\n\n* patients with a diagnosed tumor of the esophagus or upper airway, or with strong clinical suspicion of a tumor of the esophagus or upper airway\n* severe neurological disease affecting swallowing\n* pregnancy\n* surgery involving the head, neck, or esophagus within the last 6 months","ALL","18 Years","75 Years",{"count":75,"type":76},160,"ESTIMATED","INTERVENTIONAL",[79],"NA","The aim of this project is to perform a detailed evaluation of upper esophageal sphincter function and the swallowing mechanism in patients with swallowing disorders or suspected extraesophageal reflux using high-resolution manometry with impedance and 24-hour pH-impedance monitoring.",[82,83,16,84],"Extraesophageal Reflux","Laryngopharyngeal Reflux","Chronic Cough",[86,87,16,88,89,90],"Extraesophageal reflux","Laryngopharyngeal reflux","Chronic cough","high-resolution manometry","24-hour pH-impedance monitoring","NOT_YET_RECRUITING","2026-01-15",{"date":94,"type":95},"2026-01-23","ACTUAL",{"date":97,"type":76},"2026-01",{"date":99,"type":76},"2028-12",{"name":5,"class":6},1]