[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618852":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":20,"locations":20,"responsibleParty":21,"collaborators":20,"id":23,"slug":24,"hasResults":25,"nctId":26,"briefTitle":27,"officialTitle":27,"acronym":28,"eligibilityCriteria":29,"healthyVolunteers":25,"sex":30,"minAge":31,"maxAge":20,"enrollmentInfo":32,"targetDuration":20,"studyType":35,"phases":36,"briefSummary":38,"conditions":39,"keywords":20,"overallStatus":42,"whyStopped":20,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":20},{"fullName":5,"class":6},"Mid and South Essex NHS Foundation Trust","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Invasive Coronary function Assessment arm","EXPERIMENTAL","Invasive coronary endothelial function and vasospasm assessment",[13],"Procedure: Invasive coronary physiological measurements",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Invasive coronary physiological measurements","Invasive assessment of changes in coronary blood flow, resistance, and distal pressure in response to acetylcholine infusion. These will be measured during a clinical indicated invasive coronary angiogram procedure and physiological studies using a standard coronary pressure wire and a dedicated infusion catheter.",[9],null,{"type":22,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100618852","comprehensive-diagnostic-assessment-of-coronary-endothelial-function-impairment-and-vasospasm-with-continuous-thermodilution-in-patients-with-suspected-coronary-microvascular-and-vasomotor-dysfunction-100618852",false,"NCT07337005","CompREhensive Diagnostic Assessment of Coronary Endothelial Function Impairment and Vasospasm With CoNtinuous ThErmodilution in Patients With Suspected Coronary Microvascular and Vasomotor Dysfunction","REDEFINE-CMD","Inclusion Criteria:\n\n1. Patients with symptoms suggestive of angina.\n2. Evidence of unobstructed coronary arteries on invasive or non-invasive coronary angiography (coronary stenosis \\\u003C50% and \u002For FFR \\>0.80).\n3. Above the age of 18.\n4. The subject has been informed of the nature of the study, agrees to its provisions and has signed written informed consent.\n\nExclusion Criteria:\n\n1. Pregnancy.\n2. Contraindication to angiography and\u002For physiological assessment with adenosine or acetylcholine.\n3. Previous coronary artery bypass graft (CABG).\n4. Moderate to severe valvular heart disease.","ALL","18 Years",{"count":33,"type":34},100,"ESTIMATED","INTERVENTIONAL",[37],"NA","The goal of this observational study is to learn more about the diagnosis of coronary endothelium function and coronary vasospasm using a dedicated invasive protocol in patients who has angina without obstruction in their main heart arteries. The main question it aims to answer is the feasibility, reproducibility, and safety of this invasive protocol:\n\nDoes this invasive protocol diagnose coronary endothelial dysfunction and vasospasm without issues?\n\nParticipants already having invasive coronary angiogram and physiological studies will undergo additional physiological measurements during the same procedure.\n\nParticipants will enrol in a symptoms and quality of life questionnaire using dedicated questionnaires and a mobile application to assess the burden of their symptoms before and after the invasive procedure and up to 12 months follow up.\n\nA subset of participants will undergo a repeat set of these measurements to assess reproducibility of the invasive protocol.\n\nA subset of the participants will also undergo a cardiac MRI to assess correlation with the invasive protocol measurements.",[40,41],"Coronary Microvascular Dysfunction (CMD)","Vasospasm, Coronary","NOT_YET_RECRUITING","2026-01-07",{"date":45,"type":46},"2026-01-13","ACTUAL",{"date":48,"type":34},"2025-12-15",{"date":50,"type":34},"2027-12",{"name":5,"class":6}]