[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627470":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":34,"locations":34,"responsibleParty":35,"collaborators":34,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":34,"eligibilityCriteria":45,"healthyVolunteers":41,"sex":46,"minAge":47,"maxAge":34,"enrollmentInfo":48,"targetDuration":34,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":61,"overallStatus":65,"whyStopped":34,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":71,"leadSponsor":73,"locationsCount":34},{"fullName":5,"class":6},"UMC Utrecht","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Percutaneous coronary intervention","ACTIVE_COMPARATOR","Standard care arm, in which participants will receive their percutaneous coronary intervention (PCI) according to local practice standards and guidelines",[13],"Procedure: Percutaneous coronary intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Percutaneous coronary intervention + coronary function testing","EXPERIMENTAL","In the intervention group, participants will receive coronary function testing (CFT) before and after their percutaneous coronary intervention to test for coronary microvascular dysfunction and coronary vasospasm",[19,13],"Diagnostic Test: Coronary function testing",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIAGNOSTIC_TEST","Coronary function testing","Coronary function testing to test for coronary microvascular dysfunction and coronary vasospasm",[15],[27],"CFT",{"type":29,"name":9,"description":30,"armGroupLabels":31,"otherNames":32},"PROCEDURE","Percutaneous coronary intervention performed according to local practice standards and guidelines",[9,15],[33],"PCI",null,{"type":36,"investigatorFullName":37,"investigatorTitle":38,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","Tim P. van de Hoef","Doctor.","100627470","comprehensive-invasive-physiological-evaluation-of-obstructive-coronary-artery-disease-100627470",false,"NCT07449052","Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease","Inclusive Invasive Physiological Assessment in Angina Syndromes - Obstructive Coronary Artery Disease","Inclusion Criteria:\n\n* Patients \\>18 years of age\n* Hemodynamically relevant obstructive coronary artery disease (as assessed by pressure wire evaluation) in the left anterior descending coronary artery amenable to percutaneous coronary intervention at the discretion of the operator.\n\nExclusion Criteria:\n\n* Prior coronary artery bypass graft surgery.\n* Stenosis \\>90% in the target vessel or a stenosis deemed unsafe for pressure wire instrumentation\n* Known severe left ventricular dysfunction (left ventricular ejection fraction by any imaging modality)\n* Severe valvular disease\n* Renal impairment (estimated glomerular filtration rate \\\u003C30mL\u002Fmin)\n* Contra-indications for the use of adenosine or acetylcholine\n* Expected inability to conform to the clinical follow-up\n* Unable or unwilling to use the ORBITA-app\n* Life expectancy of less than 12 months.","ALL","18 Years",{"count":49,"type":50},450,"ESTIMATED","INTERVENTIONAL",[53],"NA","The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with obstructive coronary artery disease who undergo percutaneous coronary intervention. The main question it aims to answer is:\n\nDoes performing coronary function testing in patients with obstructive coronary artery disease who undergo percutaneous coronary intervention lead to better relieve of angina symptoms and improvement in quality of life?\n\nResearchers will compare this group undergoing coronary function testing with a control group who will solely undergo percutaneous coronary intervention.\n\nParticipants will:\n\n* Undergo percutaneous coronary intervention and coronary function testing in the intervention arm\n* Undergo percutaneous coronary intervention in the control arm",[56,57,58,59,60],"Coronary Artery Disease (CAD)","Obstructive Coronary Artery Disease","Coronary Microvascular Dysfunction (CMD)","Vasospasm, Coronary","Stable Angina Pectoris",[62,63,64],"Coronary Function Testing","Percutaneous Coronary Intervention","Stable Angina","NOT_YET_RECRUITING","2026-04-30",{"date":68,"type":69},"2026-05-01","ACTUAL",{"date":68,"type":50},{"date":72,"type":50},"2029-03-01",{"name":5,"class":6}]