[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100430149":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":47,"centralContacts":51,"locations":57,"responsibleParty":76,"collaborators":46,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":46,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":46,"overallStatus":59,"whyStopped":46,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University of Calgary","OTHER",[8,15,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Waist-High Compression Tights and Medications","EXPERIMENTAL","Participants will wear the waist-high compression garment while taking their regularly prescribed medications. This arm will evaluate the effects of waist-high compression garment treatment together with medications that modulate heart rate and blood pressure. This arm will also include control measurements before the garment is put on and after the garment is removed.",[13,14],"Other: Waist-High Compression Tights","Drug: Medications that modulate heart rate and blood pressure",{"label":16,"type":10,"description":17,"interventionNames":18},"Waist-High Compression Tights and No Medications","Participants will wear the waist-high compression garment while holding their regular medications that modulate heart rate and blood pressure (beta-blockers, midodrine, ivabradine, stimulants). This arm will look at the effectiveness of waist-high compression without medications. This arm will also include control measurements before the garment is put on and after the garment is removed.",[13],{"label":20,"type":10,"description":21,"interventionNames":22},"Abdominal Compression Garments and Medications","Participants will wear the abdominal compression garment while taking their regularly prescribed medications. This arm will evaluate the effects of abdominal compression garment treatment together with medications that modulate heart rate and blood pressure. This arm will also include control measurements before the garment is put on and after the garment is removed.",[23,14],"Other: Abdominal Compression Garments",{"label":25,"type":10,"description":26,"interventionNames":27},"Abdominal Compression Garments and No Medications","Participants will wear the abdominal compression garment while holding their regular medications that modulate heart rate and blood pressure (beta-blockers, midodrine, ivabradine, stimulants). This arm will look at the effectiveness of abdominal compression without medications. This arm will also include control measurements before the garment is put on and after the garment is removed.",[23],[29,35,41],{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Waist-High Compression Tights","Waist-high compression tights providing 15-40 mmHg of pressure.",[9,16],[34],"Full Length Compression Tights",{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":39},"Abdominal Compression Garments","Abdominal compression garment compressing the abdomen, buttocks, and upper thighs.",[20,25],[40],"Abdominal shapewear, compression shorts",{"type":42,"name":43,"description":44,"armGroupLabels":45,"otherNames":46},"DRUG","Medications that modulate heart rate and blood pressure","Medications that modulate heart rate and blood pressure that participants regularly take. These medications include beta-blockers, midodrine, ivabradine and stimulants.",[20,9],null,[48],{"name":49,"affiliation":5,"role":50},"Satish M Raj, MD MSCI","PRINCIPAL_INVESTIGATOR",[52],{"name":53,"role":54,"phone":55,"phoneExt":46,"email":56},"Kate M Bourne, BSc","CONTACT","403-210-7401","autonomic.research@ucalgary.ca",[58],{"facility":5,"status":59,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"RECRUITING","Calgary","Alberta","T2N 4Z6","Canada","CA",{"type":66,"coordinates":67},"Point",[68,69],-114.08529,51.05011,{"lat":69,"lon":68},[72,74],{"name":73,"role":54,"phone":55,"phoneExt":46,"email":46},"Kate Bourne",{"name":75,"role":50,"phone":46,"phoneExt":46,"email":46},"Satish R. Raj, MD MSCI",{"type":77,"investigatorFullName":46,"investigatorTitle":46,"investigatorAffiliation":46,"oldNameTitle":46,"oldOrganization":46},"SPONSOR","100430149","compression-garments-in-the-community-with-pots-100430149",false,"NCT04881318","Compression Garments in the Community With POTS","COM-COM-POTS","Inclusion Criteria:\n\n* Physician diagnosis of Postural Tachycardia Syndrome (POTS)\n* Resident of Canada\n* Owns waist-high compression garment: medical grade or commercially available tights with a pressure rating provided (e.g. 15-18 mmHg, 20-30 mmHg, 30-40 mmHg)\n* Optional Sub-Study: owns an abdominal compression garment (e.g. abdominal shapewear, waist high shorts)\n* Able to participate in a 4-day study (2x2 day segments with a 5-day washout period)\n\nExclusion Criteria:\n\n* Overt cause for postural tachycardia (i.e., acute dehydration, thyroid disease) that precludes POTS diagnosis\n* Not a resident of Canada\n* Participants with somatization or severe anxiety symptoms will be excluded\n* Pregnant (self-reported)\n* Inability to tolerate compression garments for the duration of the study\n* Does not own a waist-high compression garment\n* Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies","ALL","18 Years","60 Years",{"count":89,"type":90},30,"ESTIMATED","INTERVENTIONAL",[93],"NA","Compression Garments are a commonly prescribed treatment in Postural Orthostatic Tachycardia Syndrome (POTS). The effectiveness of a proof-of-concept compression garment has been demonstrated in an acute laboratory setting. It is not known if commercially available compression garments that participants wear in their every day lives are effective at improving heart rate and reducing symptoms in POTS. This trial will evaluate the use of commercially available waist-high and abdominal compression garments in adults diagnosed with POTS in a community setting.",[96],"Postural Orthostatic Tachycardia Syndrome","2026-04-30",{"date":99,"type":100},"2026-05-07","ACTUAL",{"date":102,"type":100},"2021-05-17",{"date":104,"type":90},"2026-12-31",{"name":5,"class":6},1]