[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100361050":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":58,"locations":65,"responsibleParty":88,"collaborators":91,"id":102,"slug":103,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":104,"sex":110,"minAge":111,"maxAge":63,"enrollmentInfo":112,"targetDuration":63,"studyType":115,"phases":116,"briefSummary":118,"conditions":119,"keywords":123,"overallStatus":68,"whyStopped":63,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},{"fullName":5,"class":6},"Karolinska Institutet","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Chest Compression Only CPR (CO-CPR)","EXPERIMENTAL","Instructions from a dispatcher at the dispatch center to trained bystanders to perform CO-CPR with chest compressions only.",[13],"Other: Chest Compression Only CPR (CO-CPR) performed by trained bystanders after instructions from dispatchers",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard CPR (S-CPR)","ACTIVE_COMPARATOR","Instructions from a dispatcher at the dispatch center to trained bystanders to perform S-CPR with chest compressions and rescue breaths in a 30:2 ratio.",[19],"Other: Standard CPR (S-CPR) performed by trained bystanders after instructions from dispatchers",[21,29],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Chest Compression Only CPR (CO-CPR) performed by trained bystanders after instructions from dispatchers","Instructions by dispatcher to bystander to provide CPR with chest-compressions only\n\nThe instructions from the dispatcher in interventional arm include:\n\n* An ambulance is dispatched and is on it´s way to you\n* Do CPR with chest compressions only\n* Push hard on the chest with a pace of 100\u002Fminute without interruptions for rescue breathing.",[9],[26,27,28],"Chest compression only CPR","Compression only CPR","Hands-only CPR",{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Standard CPR (S-CPR) performed by trained bystanders after instructions from dispatchers","Instructions by dispatcher to bystander to provide CPR with chest-compressions and rescue breaths in a ration of 30:2\n\nThe Instructions from the dispatcher in the control arm include:\n\n* An ambulance is dispatched and is on it´s way to you\n* Do CPR with chest compressions and rescue breathing\n* Push hard on the chest 30 times and give 2 rescue breaths. The pace of the compressions should be 100\u002Fminute.",[15],[34],"Standard CPR",[36,39,43,45,47,49,51,53,55],{"name":37,"affiliation":5,"role":38},"Jacob Hollenberg, MD, PhD","PRINCIPAL_INVESTIGATOR",{"name":40,"affiliation":41,"role":42},"Giuseppe Ristagno, MD, PhD","University of Milan","STUDY_CHAIR",{"name":44,"affiliation":5,"role":42},"Gabril Riva, MD, PhD",{"name":46,"affiliation":5,"role":42},"Martin Jonsson, McS, PhD",{"name":48,"affiliation":5,"role":42},"Mattias Ringh, MD, PhD",{"name":50,"affiliation":5,"role":42},"Per Nordberg, MD, PhD",{"name":52,"affiliation":5,"role":42},"Annette Nord, RN, PhD",{"name":54,"affiliation":5,"role":42},"Andreas Claesson, RN, PhD",{"name":56,"affiliation":57,"role":42},"Marcus Skrifvars, MD, PhD","University of Helsinki",[59],{"name":60,"role":61,"phone":62,"phoneExt":63,"email":64},"Jacob Hollenberg, MD. PhD","CONTACT","004686163816",null,"jacob.hollenberg@ki.se",[66,78],{"facility":67,"status":68,"city":69,"state":63,"zip":63,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":63},"AREU, Agenzia Regionale Emergenza Urgenza","RECRUITING","Bergamo","Italy","IT",{"type":73,"coordinates":74},"Point",[75,76],9.66721,45.69601,{"lat":76,"lon":75},{"facility":79,"status":68,"city":80,"state":63,"zip":63,"country":81,"countryCode":82,"cosmosGeoPoint":83,"geoPoint":87,"contacts":63},"SOS Alarm AB","Stockholm","Sweden","SE",{"type":73,"coordinates":84},[85,86],18.06871,59.32938,{"lat":86,"lon":85},{"type":38,"investigatorFullName":89,"investigatorTitle":90,"investigatorAffiliation":5,"oldNameTitle":63,"oldOrganization":63},"Jacob Hollenberg","Professor, Head of research - Centre For Resuscitation Science.",[92,94,97,99],{"name":93,"class":6},"Swedish Heart Lung Foundation",{"name":95,"class":96},"SOS Alarm","UNKNOWN",{"name":98,"class":6},"Azienda Regionale Emergenza Urgenza - AREU Lombardia",{"name":100,"class":101},"The Swedish Research Council","OTHER_GOV","100361050","compression-only-cpr-versus-standard-cpr-in-out-of-hospital-cardiac-arrest---a-randomized-survival-study-100361050",false,"NCT03981107","Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Survival Study","A Randomized Trial Comparing Survival After of a Simplified Form of Cardiopulmonary Resuscitation (CPR) Consisting of Compressions Only Compared to CPR With Compressions and Rescue Breaths","TANGO2","Inclusion Criteria:\n\n* Unconsciousness with no, abnormal or agonal breathing (suspected OHCA)\n* The suspected OHCA is witnessed (seen or heard)\n* Any Bystander at the scene has previous training in CPR\n\nExclusion Criteria:\n\n* Age below 18 years\n* Collapse is not witnessed\n* Bystander has no prior CPR training\n* Obvious asphyxia (i.e. hanging, foreign body, suffocation, strangulation)\n* Obvious drug overdose \u002F intoxication\n* Pregnancy\n* Trauma (penetrating, blunt, burn injury)\n\nPost randomisation exclusion Criteria from data analysis:\n\n* Not EMS-verified cardiac arrest\n* Previous do not resuscitate (DNR) decision","ALL","18 Years",{"count":113,"type":114},3260,"ESTIMATED","INTERVENTIONAL",[117],"NA","Out-of-hospital cardiac arrest (OHCA) is one of the leading causes of mortality in the industrialized world. Bystander CPR before arrival of the Emergency Medical Service (EMS) is associated with an increased chance of survival.\n\nDuring the last decade, the best form of bystander CPR has been debated. Chest Compression Only CPR (CO-CPR) has been advocated as a preferable method in situations where the bystander has no previous knowledge in CPR, both because its believed to be equally efficient but also a simplified form of CPR that could lead to a higher incidence of bystander-CPR.\n\nIn an initiative to increase CPR rates the American Heart Association has launched public campaigns such as the \"hands-only CPR\" promoting CO-CPR as an option to S-CPR for adult non-asphyxic cardiac arrest. In the 2015 updates of the European resuscitation council guidelines it states that the confidence in the equivalence between the two methods is not sufficient to change current practice.\n\nWhether CO-CPR leads to a survival rate no worse than, or even superior to standard CPR in situations where the bystander has previous CPR training remains unclear. This clinical question remains unanswered while millions of people are trained in CPR worldwide each year.\n\nTo investigate whether CO-CPR is non-inferior to standard CPR (S-CPR) when performed by a bystander with previous CPR training in witnessed, non-asphyxic cases of OHCA. Superiority testing will also be performed for the purpose of demonstrating a possible increase in survival with CO-CPR.",[120,121,122],"Out-Of-Hospital Cardiac Arrest","Cardiac Arrest","Cardiopulmonary Resuscitation",[122,124,125,121],"Chest compressions only CPR","Dispatcher assisted CPR","2026-05-04",{"date":128,"type":129},"2026-05-08","ACTUAL",{"date":131,"type":129},"2017-01-01",{"date":133,"type":114},"2028-12-31",{"name":5,"class":6},2]