[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100452294":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":37,"locations":45,"responsibleParty":64,"collaborators":25,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":25,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":25,"enrollmentInfo":76,"targetDuration":25,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":48,"whyStopped":25,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Centre Hospitalier Universitaire Vaudois","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group (CTR)","ACTIVE_COMPARATOR","Computerized Gaming Rehabilitation Program 1",[13],"Device: Computerized Gaming Rehabilitation Program 1",{"label":15,"type":16,"description":17,"interventionNames":18},"Intervention group (INT)","EXPERIMENTAL","Computerized Gaming Rehabilitation Program 2",[19],"Device: Computerized Gaming Rehabilitation Program 2",[21,26],{"type":22,"name":11,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Brain training games with physical exercise component.",[9],null,{"type":22,"name":17,"description":27,"armGroupLabels":28,"otherNames":25},"Cognitive training games with physical exercise component.",[15],[30,34],{"name":31,"affiliation":32,"role":33},"Arseny A. Sokolov, Prof MD PhD","Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":32,"role":36},"Giulia Binarelli, PhD","STUDY_CHAIR",[38,42],{"name":35,"role":39,"phone":40,"phoneExt":25,"email":41},"CONTACT","+41 21 314 25 42","giulia.binarelli@chuv.ch",{"name":31,"role":39,"phone":43,"phoneExt":25,"email":44},"+41 79 556 73 55","arseny.sokolov@chuv.ch",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Lausanne University Hospital (CHUV)","RECRUITING","Lausanne","Canton of Vaud","1011","Switzerland","CH",{"type":55,"coordinates":56},"Point",[57,58],6.63282,46.516,{"lat":58,"lon":57},[61],{"name":62,"role":39,"phone":40,"phoneExt":25,"email":63},"Aurélie Manuel Stocker, PhD","aurelie.manuel-stocker@chuv.ch",{"type":33,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Prof. Arseny Sokolov, MD, PhD","Professor","100452294","computerized-cognitive-rehabilitation-of-executive-deficits-in-stroke-patients-100452294",false,"NCT05169632","Computerized Cognitive Rehabilitation of Executive Deficits in Stroke Patients","Combined Cognitive and Physical Training for the Neurorehabilitation of Executive Deficits After Stroke: an Exploratory Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Ischemic or haemorrhagic cerebral stroke ≥ 8 weeks before study inclusion\n* Cognitive complaint and\u002For clinical impression of dysexecutive syndrome\n* Z-Score \\\u003C -1.0 in at least two of the following domains\n\n  * Cognitive flexibility (Trail-Making Test B\u002FA)\n  * Cognitive interference (Stroop color word interference task)\n  * Divided attention (TAP divided attention)\n  * Working memory (TAP working memory, Forward Digit Span, Backward Digit Span)\n  * Design fluency (Five-points test)\n\nExclusion Criteria:\n\n* Major neurocognitive disorder according to the DSM-5\n* Proximal extremity paresis grade \\\u003C M4 on the Medical Research Council (MRC) Scale for Muscle Strength in at least one of four extremities\n* Insufficient visual acuity, visual field or hemispatial attention to engage in the training\n* Inability to discriminate colour: \\\u003C 12 points on the Ishihara test\n* Changes over the last 4 weeks in antidepressive, anxiolytic or in acetylcholinesterase inhibitor drugs\n* Thoracic pain and\u002For heart palpitations at rest, during or following a physical effort (based on self-report)\n* Clinically unstable cardio-vascular disease\n* Falls in the past 12 weeks as evaluated in the enrolment interview \\[Hopkins Falls Grading Scale (Grade \\>1)\\]\n* High risk of falling according to a score of over 15 seconds on the Four Square Step Test (FSST)\n* Insufficient knowledge or capacity of French to follow instructions\n* Incapacity or unwillingness to provide informed consent","ALL","18 Years",{"count":77,"type":78},32,"ESTIMATED","INTERVENTIONAL",[81],"NA","WHO: 32 participants with executive deficits related to a stroke, able to engage in moderate physical activity.\n\nWHY: Around one third of stroke patients suffer from cognitive deficits in the long term, which have a detrimental impact on everyday personal and professional life. The purpose of this study is to evaluate two sets of computerized exercises combining cognitive and physical effort to see if they can improve executive function.\n\nWHAT: Study participants first undergo cognitive and physical assessments. Additional questionnaires will assess mood, everyday life cognition, function and quality. This will be followed by a 6 week training period with 3 training sessions a week. The effect of the cognitive and physical training will be measured in a post-training evaluation session. Six months after completion of the training, the study will evaluate cognitive and physical abilities of participants to study long-term effects of the respective training program.\n\nWHERE: Both the evaluation and the training sessions will be conducted on the premises of the Centre Hospitalier Universitaire Vaudoise (Pavillon 4, Avenue de Beaumont, 1005 Lausanne, Switzerland)",[84,85],"Stroke","Executive Dysfunction",[87,88,89,90,91,92,93,94,95,96,97,98,99,100],"Stroke Rehabilitation","Neurological Rehabilitation","Exercise Therapy","Brain Training","Nervous System Diseases","Neurocognitive Disorders","Cognition Disorders","Mental Disorders","Vascular System Injuries","Cerebrovascular Disorders","Multimodal Intervention","e-Health","Digital Intervention","Exergame","2024-08-12",{"date":103,"type":104},"2024-08-13","ACTUAL",{"date":106,"type":104},"2022-03-17",{"date":108,"type":78},"2025-06-30",{"name":5,"class":6},1]