[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630570":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":24,"locations":31,"responsibleParty":65,"collaborators":67,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":23,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":23,"enrollmentInfo":81,"targetDuration":23,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":34,"whyStopped":23,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"University of Deusto","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Multimodal exercise program during chemoradiotherapy","EXPERIMENTAL","Patients will start 2 weeks prior to radiotherapy treatment. The intervention will consist of 3 days of aerobic exercise, 2 days of resistance training and 5 days of unsupervised inspiratory muscle training during 9 weeks.",[13],"Other: Multimodal exercise",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Multimodal exercise","The intervention consists of 7-9 weeks of multimodal exercise training prior to radiotherapy session.\n\n1. Aerobic exercise: 40' of moderate intensity on stationary bike or treadmill; 3 days\u002Fweek.\n2. Resistance training: 16 sets of 8 reps. at 80% of 1RM; 1' rest between sets; 2 days\u002Fweek.\n3. Inspiratory Muscle Training: 2x30 breathing cycles at 30% of PIMax + 5% weekly improvement; 4 days unsupervised + 1 supervised session.",[9],[20,21,22],"Aerobic exercise","Resistance training","Breathing exercise",null,[25],{"name":26,"role":27,"phone":28,"phoneExt":29,"email":30},"Jurgi Zulaika","CONTACT","+34 943 32 66 00","5190","jurgi.zulaika@deusto.es",[32,50],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Hospital Clinic de Barcelona","RECRUITING","Barcelona","Catalonia","08036","Spain","ES",{"type":41,"coordinates":42},"Point",[43,44],2.15899,41.38879,{"lat":44,"lon":43},[47],{"name":48,"role":27,"phone":49,"phoneExt":23,"email":30},"Raquel Sebio","0034 932275400",{"facility":51,"status":34,"city":52,"state":53,"zip":54,"country":38,"countryCode":39,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Hospital Universitario de Navarra","Pamplona","Navarre","31008",{"type":41,"coordinates":56},[57,58],-1.64323,42.81687,{"lat":58,"lon":57},[61],{"name":62,"role":27,"phone":63,"phoneExt":23,"email":64},"Núria Bultó","0034 848422222","nuria.bulto.boque@navarra.es",{"type":66,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[68,70],{"name":69,"class":6},"Hospital Clinic of Barcelona",{"name":71,"class":6},"Hospital of Navarra","100630570","concomitant-use-of-radiotherapy-and-integrated-exercise---lung-cancer-100630570",false,"NCT07489391","Concomitant Use of Radiotherapy and Integrated Exercise - Lung Cancer","Effect of an Integrated Exercise Program Concomitant With Radiotherapy on Functional Capacity in Patients With Lung Cancer","Inclusion Criteria:\n\n* Histological diagnosis of non-small cell lung cancer (NSCLC) at stage II-III (locally advanced), unresectable\u002Finoperable.\n* Candidate for radical radiotherapy with concomitant chemotherapy, with or without maintenance Durvalumab.\n* ECOG performance status ≤2 (or Karnofsky index ≥60).\n* Ability to communicate adequately with the research team and to complete questionnaires and functional tests.\n* Signed written informed consent after receiving detailed information about the study.\n\nExclusion Criteria:\n\n* Decompensated cardiorespiratory comorbidities that contraindicate moderate-intensity physical exercise:\n\n  * New York Heart Association (NYHA) class III-IV congestive heart failure or unstable angina.\n  * Recent myocardial infarction (\\\u003C6 months) or uncontrolled arrhythmias.\n  * Very severe chronic obstructive pulmonary disease (COPD) GOLD IV with recent exacerbations, permanent home oxygen therapy, or severe pulmonary hypertension.\n* Severe physical or neurological limitations that prevent exercise.\n* Absolute medical contraindications to inspiratory muscle training: unresolved pneumothorax, recent thoracic surgery (\\\u003C4 weeks), or active hemoptysis.\n* Refusal or inability to understand\u002Ffollow the program instructions (e.g., severe cognitive impairment, insurmountable language barrier).","ALL","18 Years",{"count":82,"type":83},10,"ESTIMATED","INTERVENTIONAL",[86],"NA","Study objective and procedures\n\nThe objective of CURIE-LC is to evaluate the feasibility (i.e., whether it is possible and safe) of carrying out a comprehensive exercise program during combined radiotherapy and chemotherapy in patients with lung cancer. The study will assess whether patients can adhere to the exercise program while receiving oncologic treatment and will explore its effects on physical fitness and quality of life.\n\nWhat does participation involve?\n\nIf participants choose to take part, they will join a supervised exercise program conducted throughout the chemoradiotherapy treatment. The program includes three main components, tailored to the individuals' abilities:\n\nInspiratory breathing exercise: training with a specialized device to strengthen the breathing muscles and improve lung capacity.\n\nAerobic exercise: moderate-intensity aerobic activity (e.g., treadmill walking or stationary cycling) several days per week to improve endurance and cardiovascular health.\n\nStrength training: muscle-strengthening exercises (e.g., light weights or resistance bands) twice per week to maintain or increase arm and leg strength.\n\nA physiotherapist or other trained professional will guide the participant at all times to ensure exercises are performed safely and appropriately. Sessions will last approximately 20 to 60 minutes and will be coordinated with the radiotherapy\u002Fchemotherapy schedule so as not to interfere with the treatment.\n\nIn addition to the exercise sessions, participants will undergo physical assessments and complete questionnaires at several time points. Before starting and at the end of the program, the investigagtors will measure functional capacity using the 6-minute walk test (6MWT) and assess respiratory muscle strength using maximal inspiratory and expiratory pressures (PImax and PEmax). Handgrip strength will also be measured. Participants will complete questionnaires about health status, fatigue, mood, and quality of life. These evaluations will help determine the impact of exercise during treatment.\n\nThe exercise program will last for the duration of the treatment, approximately 7 to 9 weeks, with a short-term follow-up after treatment ends. Overall, participation involves attending the scheduled weekly exercise sessions during treatment, plus several evaluation visits (before, during, at the end of the program, and a few months later). Exact timing and frequency will be explained and planned according to the individual situation, aiming to minimize disruption to daily routine.",[89,90,91],"Non Small Cell Lung Cancer","Radiation Therapy Patient","Stage II\u002FIII",[93,94,95],"Lung Cancer","Exercise","Radiochemotherapy","2026-04-30",{"date":98,"type":99},"2026-05-06","ACTUAL",{"date":101,"type":83},"2026-04",{"date":103,"type":83},"2026-12",{"name":5,"class":6},2]