[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618534":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":52,"collaborators":26,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":26,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":26,"enrollmentInfo":63,"targetDuration":26,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":81,"whyStopped":26,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Yonsei University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"SYNC group","EXPERIMENTAL","Combined procedure of ICD implantation, LBBP lead insertion, and AVJ ablation.",[13],"Device: LBBP + AVJ Ablation with ICD",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","ACTIVE_COMPARATOR","Standard ICD implantation with minimal ventricular pacing strategy.",[19],"Device: ICD Only",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","LBBP + AVJ Ablation with ICD","Insertion of an LBBP lead (Medtronic SelectSecure™ 3830) and performing AVJ ablation to ensure heart rate regularization and ventricular synchronization",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"ICD Only","Participants receive standard ICD implantation with a minimal ventricular pacing strategy",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"tae hoon kim, MD, PhD.","CONTACT","82-2-2228-8467.","thkimcardio@yuhs.ac",[38],{"facility":39,"status":26,"city":40,"state":26,"zip":26,"country":41,"countryCode":26,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Division of Cardiology, Yonsei University College of Medicine.","Seoul","South Korea",{"type":43,"coordinates":44},"Point",[45,46],126.9784,37.566,{"lat":46,"lon":45},[49],{"name":50,"role":34,"phone":51,"phoneExt":26,"email":36},"tae hoon kim, MD, PhD","82-2-2228-8467",{"type":53,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100618534","conduction-system-pacing-and-av-junction-ablation-in-heart-failure-with-atrial-fibrillation-sync-af-htx-100618534",false,"NCT07332871","Conduction System Pacing and AV Junction Ablation in Heart Failure With Atrial Fibrillation (SYNC AF-HTx)","Safety and efficacY of conductioN System paCing and Atrioventricular Junctional Ablation Combined With ICD Implantation in Patients With End-stage Heart Failure and Atrial Fibrillation Eligible for Heart Transplantation (SYNC AF-HTx) : Multicenter Prospective Randomized Controlled Trial","Inclusion Criteria:\n\nCandidates for ICD implantation (primary or secondary prevention). Permanent AF (\\>6 months) unsuitable for or failed catheter ablation. End-stage heart failure considering heart transplant or LVAD. LVEF ≤ 35 within 6 weeks before enrollment. NYHA functional class ≥ II. On GDMT for at least 3 months. Age ≥ 19 years.\n\nExclusion Criteria:\n\nExisting LVAD or prior heart transplantation. Indications for cardiac resynchronization therapy (CRT). History of mechanical tricuspid valve replacement. Expected survival≤ 12 months. Inability to comply with the study protocol.","ALL","19 Years",{"count":64,"type":65},120,"ESTIMATED","INTERVENTIONAL",[68],"NA","The purpose of this study is to evaluate the safety and efficacy of conduction system pacing (CSP) using left bundle branch pacing (LBBP) and atrioventricular junction (AVJ) ablation in patients with end-stage heart failure and permanent atrial fibrillation (AF). Participants who are candidates for heart transplantation or left ventricular assist device (LVAD) implantation will be randomized to either the SYNC group (ICD implantation combined with LBBP and AVJ ablation) or the control group (ICD implantation only). The investigators will compare clinical outcomes, including mortality and heart failure hospitalization, between the two strategies over a 1-year follow-up period.",[71,72,73],"Heart Failure","Atrial Fibrillation","Defibrillators, Implantable",[75,76,77,78,79,80],"Left Bundle Branch Pacing (LBBP)","Conduction System Pacing (CSP)","Atrioventricular Junction Ablation (AVJ ablation)","End-stage Heart Failure","Heart Transplantation","ICD","NOT_YET_RECRUITING","2025-12-30",{"date":84,"type":85},"2026-01-12","ACTUAL",{"date":87,"type":65},"2026-01",{"date":89,"type":65},"2028-05",{"name":5,"class":6},1]