[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100524196":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":39,"locations":47,"responsibleParty":65,"collaborators":68,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":73,"sex":79,"minAge":80,"maxAge":25,"enrollmentInfo":81,"targetDuration":25,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":50,"whyStopped":25,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Hospital Clinic of Barcelona","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Conduction system pacing","EXPERIMENTAL","Pacing the His-Purkinje system.\n\nCrossover to biventricular pacing allowed in case of failed conduction system pacing: failed His bundle pacing and failed Left bundle branch pacing (high thresholds (\\>3.5V \u002F 1ms); no left bundle branch pacing criteria; no left bundle branch correction).\n\nElectrocardiographic optimization allowed in order to obtain the narrowest QRS.",[13],"Procedure: Conduction system pacing",{"label":15,"type":16,"description":17,"interventionNames":18},"Biventricular pacing","ACTIVE_COMPARATOR","Pacing from the right ventricular and coronary sinus lead. Electrocardiographic optimization with fusion-optimized intervals (FOI).\n\nCrossover from biventricular pacing to conduction system pacing will be allowed in the following situations: coronary sinus cannot be cannulated; no lateral or posterolateral branches; or phrenic stimulation.",[19],"Procedure: Biventricular pacing",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Conduction system pacing implant as a Resynchronization therapy.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Biventricular pacing implant",[15],[30,34,36],{"name":31,"affiliation":32,"role":33},"José Mª Tolosana, MD, PhD","Hospital Clínic de Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":32,"role":33},"Margarida Pujol López, MD",{"name":37,"affiliation":32,"role":38},"Lluís Mont, MD, PhD","STUDY_CHAIR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":25,"email":44},"Jose Mª Tolosana, MD, PhD","CONTACT","93 2271778 (2094)","tolosana@clinic.cat",{"name":35,"role":42,"phone":43,"phoneExt":25,"email":46},"mapujol@clinic.cat",[48],{"facility":49,"status":50,"city":51,"state":25,"zip":25,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Hospital Clínic de Barcelona","RECRUITING","Barcelona","Spain","ES",{"type":55,"coordinates":56},"Point",[57,58],2.15899,41.38879,{"lat":58,"lon":57},[61,63],{"name":62,"role":42,"phone":25,"phoneExt":25,"email":44},"JM Tolosana, MD, PhD",{"name":64,"role":42,"phone":25,"phoneExt":25,"email":25},"M Pujol Lopez, MD",{"type":33,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Josep Lluis Mont Girbau","Head of Arrhythmia Research.",[69],{"name":70,"class":6},"Institut d'Investigacions Biomèdiques August Pi i Sunyer","100524196","conduction-system-pacing-vs-biventricular-pacing-in-systolic-dysfunction-and-wide-qrs-mortality-heart-failure-hospitalization-or-cardiac-transplant-100524196",false,"NCT06105580","Conduction System Pacing vs Biventricular Pacing in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant","Conduction System Pacing vs Biventricular Resynchronization Therapy in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant","CONSYST-CRT II","Inclusion Criteria:\n\n* Patient must indicate acceptance to participate in the study by signing an informed consent document.\n* Patient must be ≥ 18 years of age.\n* Left bundle branch block, QRS ≥130 and LVEF \\\u003C=35%. No indication of stimulation for AV block.\n* Non-left bundle branch block, QRS ≥150 and LVEF \\\u003C=35%.\n* Resynchronization therapy indication for ventricular dysfunction (LVEF \\\u003C40%) and indication of cardiac pacing for AV block.\n* LVEF \\\u003C=35% in NYHA class III or IV, atrial fibrillation and intrinsic QRS \\>=130 ms, provided a strategy to ensure biventricular capture is in place.\n\nExclusion Criteria:\n\n* Myocardial infarction, unstable angina or cardiac revascularization during the previous 3 months.\n* Pregnancy.\n* Participating currently in a clinical investigation that includes an active treatment.","ALL","18 Years",{"count":82,"type":83},320,"ESTIMATED","INTERVENTIONAL",[86],"NA","Conduction system pacing vs biventricular resynchronization therapy in systolic dysfunction and wide QRS: mortality, heart failure hospitalization or cardiac transplant (CONSYST-CRT II trial).\n\nSuperiority trial that aims to study the composite endpoint consisting of all-cause mortality, cardiac transplant or heart failure hospitalization at 12-month follow-up.",[89,90],"Cardiac Resynchronization Therapy","Heart Failure",[92,93,94],"left bundle branch pacing","biventricular pacing","cardiac resynchronization therapy","2026-03-30",{"date":97,"type":98},"2026-04-03","ACTUAL",{"date":100,"type":98},"2023-11-27",{"date":102,"type":83},"2028-01",{"name":5,"class":6},1]