[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100440466":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":39,"responsibleParty":62,"collaborators":64,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":11,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":11,"enrollmentInfo":79,"targetDuration":11,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":42,"whyStopped":11,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"left bundle branch pacing","EXPERIMENTAL",null,[13],"Device: Left bundle branch pacing lead",{"label":15,"type":16,"description":11,"interventionNames":17},"Right ventricular pacing","ACTIVE_COMPARATOR",[18],"Device: Right ventricular active fixation lead",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DEVICE","Left bundle branch pacing lead","Implantation of a left bundle branch pacing lead via sheath, to perform selective or non-selective pacing",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Right ventricular active fixation lead","Active fixation lead (standard)",[15],[30,36],{"name":31,"role":32,"phone":33,"phoneExt":34,"email":35},"Jacqueline Joza, MD MSc","CONTACT","514-934-1934","43158","jacqueline.joza@gmail.com",{"name":37,"role":32,"phone":33,"phoneExt":11,"email":38},"Fiorella Rafti, PhD","fiorella.rafti@mail.mcgill.ca",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"McGill University Health Centre-Research Institute","RECRUITING","Montreal","Quebec","H3Y2T6","Canada","CA",{"type":49,"coordinates":50},"Point",[51,52],-73.58781,45.50884,{"lat":52,"lon":51},[55,56,58,60],{"name":37,"role":32,"phone":33,"phoneExt":11,"email":38},{"name":57,"role":32,"phone":33,"phoneExt":34,"email":35},"Jacqueline Joza",{"name":57,"role":59,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"name":61,"role":59,"phone":11,"phoneExt":11,"email":11},"Atul Verma",{"type":59,"investigatorFullName":57,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Cardiac electrophysiologist",[65,67],{"name":66,"class":6},"Heart and Stroke Foundation of Canada",{"name":68,"class":69},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV","100440466","conduction-system-pacing-with-left-bundle-branch-pacing-as-compared-to-standard-right-ventricular-pacing-100440466",false,"NCT05015660","Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing","LEFT Bundle Pacing vs Standard Right Ventricular Pacing for Heart Failure","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Patients with an ejection fraction of \\>35%\n3. Patients with an indication for ventricular pacing and high-degree atrioventricular block where the degree of anticipated RV pacing is \\>90% including:\n\n   1. Third degree AV block\n   2. Symptomatic or asymptomatic second-degree AV block\n   3. First degree AV block ≥ 280ms with a narrow QRS, or ≥ 240ms with an intraventricular delay (QRS duration ≥120ms)\n4. Echocardiogram within the last 3 months, with ability to have DICOM images\n\nExclusion Criteria:\n\n1. Indication for an implantable cardioverter defibrillator\n2. Presence of a mechanical tricuspid valve\n3. Any prior attempt at implantation of an ICD, CRT, HBP, or LBBP\n4. Lack of capacity to consent\n5. Other serious medical condition with life expectancy of \\\u003C2 years\n6. Pregnancy\n7. Patients in whom the conduction system abnormality is expected to be transient or recover over time\n8. Patients with permanent atrial fibrillation","ALL","18 Years",{"count":80,"type":81},1300,"ESTIMATED","INTERVENTIONAL",[84],"NA","High burden right ventricular (RV) pacing has been shown to increase cardiovascular mortality, incidence of heart failure (HF), worsen left ventricular (LV) function and accelerate the development of atrial fibrillation (AF). High percentage ventricular pacing and wider paced QRS in the setting of normal baseline LV ejection fractions have consistently been shown to be independent risk factors for pacing-induced cardiomyopathy. Left bundle branch pacing (LBBP) has emerged as a potential alternative pacing mechanism that may avoid LV dyssynchrony and pacing-induced LV dysfunction by mimicking native electrical conduction.",[87,88],"Pacemaker DDD","Heart Block",[9],"2026-03-09",{"date":92,"type":93},"2026-03-11","ACTUAL",{"date":95,"type":93},"2022-09-01",{"date":97,"type":81},"2030-01-01",{"name":5,"class":6},1]