[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100507234":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":34,"responsibleParty":69,"collaborators":72,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":10,"studyType":89,"phases":10,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Western University, Canada","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"DCC Donors",null,"Standard criteria DCC donors will be undergoing the A-NRP perfusion process to recondition organs prior to procurement. Multimodal neuromonitors will be placed on the donor prior to withdrawal of life support and readings will be recorded during the withdrawal process and for the duration of the A-NRP perfusion process. The neuromonitoring team will be looking for evidence of brain blood flow or activity.",[13],"Other: Neuromonitoring",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Neuromonitoring","Multimodal neuromonitoring will include: Transcranial colour-coded Doppler (TCCD), Electroencephalography (EEG), and Somatosensory evoked potentials (SSEP) or brainstem auditory evoked potentials (BAEP)",[9],[20],{"name":21,"affiliation":22,"role":23},"Anton Skaro, MD PhD","London Health Sciences Centre\u002FLawson Health Research Institute","PRINCIPAL_INVESTIGATOR",[25,31],{"name":26,"role":27,"phone":28,"phoneExt":29,"email":30},"Crystal Engelage, PhD","CONTACT","519-685-8500","37517","Crystal.Engelage@lhsc.on.ca",{"name":21,"role":27,"phone":32,"phoneExt":10,"email":33},"519-663-2904","Anton.Skaro@lhsc.on.ca",[35,51],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"London Health Sciences Centre","RECRUITING","London","Ontario","N6A 5A5","Canada","CA",{"type":44,"coordinates":45},"Point",[46,47],-81.23304,42.98339,{"lat":47,"lon":46},[50],{"name":26,"role":27,"phone":28,"phoneExt":29,"email":30},{"facility":52,"status":53,"city":54,"state":39,"zip":55,"country":41,"countryCode":42,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Toronto Western Hospital","NOT_YET_RECRUITING","Toronto","M5T 2S8",{"type":44,"coordinates":57},[58,59],-79.39864,43.70643,{"lat":59,"lon":58},[62,67],{"name":63,"role":27,"phone":64,"phoneExt":65,"email":66},"Erin Winter, HBSc","416-340-4800","6093","Erin.Winter@uhn.ca",{"name":68,"role":23,"phone":10,"phoneExt":10,"email":10},"Markus Selzner, MD",{"type":23,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Anton Skaro","Director of Liver Transplantation Surgery and Associate Professor - Department of Surgery",[73],{"name":74,"class":6},"University Health Network, Toronto","100507234","confirming-permanent-lack-of-blood-flow-to-the-brain-during-a-nrp-dcc-organ-transplant-100507234",false,"NCT05884736","Confirming Permanent Lack of Blood Flow to the Brain During A-NRP DCC Organ Transplant","Confirming the Permanent Cessation of Intracranial Circulation During Abdominal Normothermic Regional Perfusion After the Determination of Death by Circulatory Criteria","CONCLUDE","Inclusion Criteria:\n\n* ≤ 18 years of age\n* Potential DCC donors whose families\u002Fsurrogate decision makers have consented to DCC organ donation according to current criteria of the participating transplant programs. These may include patients donating a liver, kidneys, pancreas, and\u002For lungs; please see Appendix A for organ specific donor inclusion criteria.\n\nExclusion Criteria:\n\n* \\\u003C 18 years of age\n* DCC donors who proceed to donation following medical assistance in dying or those who are able to provide first-person consent at the time of donation\n* Injuries that anatomically preclude the use of neurological monitoring","ALL","18 Years","75 Years",{"count":87,"type":88},30,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the surgical technique used in Abdominal Normothermic Regional Perfusion (A-NRP) in death determination by circulatory criteria (DCC) organ donors. The proposed study will demonstrate that there is no resumption of brain blood flow or activity during the A-NRP procedure. This will be assessed using multimodal neuromonitoring protocol that enables continuous focused monitoring of brain blood flow and activity during A-NRP. This will provide evidence that brain blood flow and activity does not resume during NRP and ensure donor safety in using this technique in standard of care practice.",[92],"Organ Transplant",[94,95,96,97],"A-NRP","neuromonitoring","brain activity","transplant","2026-05-15",{"date":100,"type":101},"2026-05-19","ACTUAL",{"date":103,"type":101},"2024-04-02",{"date":105,"type":88},"2027-12",{"name":5,"class":6},2]