[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596037":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":31,"locations":30,"responsibleParty":37,"collaborators":30,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":43,"sex":49,"minAge":50,"maxAge":30,"enrollmentInfo":51,"targetDuration":30,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":64,"whyStopped":30,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":30},{"fullName":5,"class":6},"China-Japan Friendship Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CLE-assisted ultrasound-guided pleural biopsy","EXPERIMENTAL","The patients in this arm will receive the CLE-assisted ultrasound-guided pleural biopsy",[13],"Procedure: Confocoal laser endomicroscopy-assisted ultrasound-guided pleural biopsy",{"label":15,"type":16,"description":17,"interventionNames":18},"Ultrasound-guided pleural biopsy","PLACEBO_COMPARATOR","The patients in this arm will receive the ultrasound-guided pleural biopsy",[19],"Procedure: Ultrasound-guided pleural biopsy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Confocoal laser endomicroscopy-assisted ultrasound-guided pleural biopsy","Using the probe-based confocal laser endomicroscopy to detect the pleural, and ensure the biopsy location. Then, use the pleural biopsy tool to complete the pleural biopsy. The whole procession will under the ultrasound guidance.",[9],[9],{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Using ultrasound to detect the biopsy site and perform pleural biopsy.",[15],null,[32],{"name":33,"role":34,"phone":35,"phoneExt":30,"email":36},"Mingming Deng, Doctor","CONTACT","+86 18801336854","isdeng1017@163.com",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Gang Hou","Deputy Director of the Department of Pulmonary and Critical Care Medicine","100596037","confocal-laser-endomicroscopy-assisted-ultrasound-guided-pleural-biopsy-100596037",false,"NCT07040241","Confocal Laser Endomicroscopy Assisted Ultrasound Guided Pleural Biopsy","Diagnostic Yield and Safety of Probe-based COnfocaL LAser Endomicroscopy and Ultrasound-guided Pleural BiOpsy in Diagnosing Patients With Unknown pleuRAl Effusion: a Protocol of a Multicenter, Randomized cONtrolled Trial (COLLABORATION-Ⅱ）","Confocal laser","Inclusion Criteria:\n\n* Adult patients with exudative pleural effusion of unknown origin\n* Patients with negative pleural fluid cytology results\n* Patients diagnosed with a probable malignant pleural effusion but without a definite diagnosis and requiring further pathological evaluation\n* Patients who are fully informed of the purpose and method of the study, agree to participate in the study, and sign an informed consent form\n\nExclusion Criteria:\n\n* Inability or refusal to undergo UGBx\n* Patients with any contraindications for pleural biopsy","ALL","18 Years",{"count":52,"type":53},260,"ESTIMATED","INTERVENTIONAL",[56],"NA","This study aimed to evaluate the diagnostic yield and safety of confocal laser endomicroscopy and ultrasound-guided pleural biopsy in diagnosing patients with unknown pleural effusion.",[59],"Pleural Effusion Disorder",[61,62,63],"Pleural effusion","Confocal laser endomicroscopy","Pleural biopsy","NOT_YET_RECRUITING","2025-06-26",{"date":67,"type":68},"2025-06-27","ACTUAL",{"date":70,"type":53},"2025-07-01",{"date":72,"type":53},"2027-07-01",{"name":5,"class":6}]