[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573097":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":56,"collaborators":59,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":26,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":26,"enrollmentInfo":85,"targetDuration":26,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":26,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"China-Japan Friendship Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"pCLE guided pleural biopsy via semi-rigid thoracoscopy","EXPERIMENTAL","pCLE will be introduced to detect suspected areas of the parietal pleura. The pCLE inspection will follow a standardized protocol with two main steps. First, any visible abnormalities under white light, such as nodules or thickening, will be examined with pCLE to evaluate intralesional heterogeneity and determine the best biopsy site. Second, the basal pleura will be systematically swept, covering at least two intercostal spaces above the costophrenic recess, including the diaphragmatic pleura and lower posterior chest wall, which are common sites for malignant involvement. After confirming the targeted area of the parietal pleura for pleural biopsy, the pCLE probe will be withdrawn, and a flexible forceps biopsy will be performed. This process will be repeated eight times, and eight samples will be obtained. All specimens will be transported in separate formalin containers with biopsy sequences for histopathological analysis.",[13],"Procedure: Confocal laser endomicroscopy guided pleural biopsy using medical thoracoscopy",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional Pleural biopsy via semi-rigid thoracoscopy","PLACEBO_COMPARATOR","For patients assigned to receive pleural biopsy via semi-rigid thoracoscopy alone, the parietal, visceral, and diaphragmatic pleura will be inspected, and eight biopsies will be obtained under direct vision in all suspected areas of the parietal pleura.",[19],"Procedure: Plerual biopsy using medical thoracoscopy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Confocal laser endomicroscopy guided pleural biopsy using medical thoracoscopy","After the completion of the routine thoracoscopic examination, the biopsy location was determined based on the results of chest CT\u002F ultrasound. The benign and malignant states of pleural lesions were explored by nCLE and image records were collected. Then, the biopsy tissues were collected under the guidance of nCLE.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Plerual biopsy using medical thoracoscopy","After the completion of the routine thoracoscopic examination, the biopsy location was determined according to the results of chest CT\u002F ultrasound, and random pathological biopsy was performed, and biopsy tissues were collected by biopsy forceps.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Gang Hou","CONTACT","13840065481","hougangcmu@163.com",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Beijing","Beijing Municipality","100029","China","CN",{"type":46,"coordinates":47},"Point",[48,49],116.39723,39.9075,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":54,"phoneExt":26,"email":55},"Mingming Deng","+86 18801336854","isdeng1017@163.com",{"type":57,"investigatorFullName":33,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Chief physician",[60,63,65,67,69,71,74],{"name":61,"class":62},"Shanghai Rui Jin Hospital","UNKNOWN",{"name":64,"class":6},"Henan Provincial People's Hospital",{"name":66,"class":6},"The Second Affiliated Hospital of Harbin Medical University",{"name":68,"class":6},"Anhui Chest Hospital",{"name":70,"class":6},"Wuhan Pulmonary Hospital",{"name":72,"class":73},"Shandong Public Health Clinical Center","OTHER_GOV",{"name":75,"class":62},"The Second People's Hospital of Gansu Province","100573097","confocal-laser-endomicroscopy-guided-medical-thoracoscopy-for-the-diagnosis-of-pleural-disease-100573097",false,"NCT06741839","Confocal Laser Endomicroscopy Guided Medical Thoracoscopy for the Diagnosis of Pleural Disease","Efficacy and Safety of Confocal Laser Endomicroscopy Guided Medical Thoracoscopy for the Diagnosis of Pleural Disease: a Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* Evidence of exudative pleural effusion in which a specific diagnosis could not be determined using clinical, radiological, laboratory, or cytological examinations\n* Willingness to participate in the study and undergo an invasive procedure.;\n\nExclusion Criteria:\n\n* Pleural thickening or pleural-based mass without pleural effusion on radiologic examination;\n* Hemodynamic instability;\n* Presence of parapneumonic effusion;\n* Any contraindication to pleural biopsy or semirigid thoracoscopy;\n* Participation in other studies within three months without withdrawal or termination.","ALL","18 Years",{"count":86,"type":87},158,"ESTIMATED","INTERVENTIONAL",[90],"NA","A prospective multicenter randomized controlled trial was conducted to evaluate the efficacy and safety of thoracoscopic biopsy guided by confocal optical real-time microscopic imaging (nCLE) in the diagnosis of fibrinal pleurisy of unknown etiology. Patients with fibrinous pleurisy of unknown etiology who were to undergo thoracoscopic pleural biopsy were enrolled and informed consent was signed. Subjects were randomized to either the nCLE guided biopsy Group (Group A) or the visual biopsy group (Group B) according to the randomization table (1:1 ratio). nCLE was used to probe the benign and malignant status of pleural lesions, compare the consistency of random pathological biopsy or nCLE guided biopsy with histopathological results, compare whether nCLE guided biopsy can reduce the number of thoracoscopic biopsies, and follow up short-term postoperative complications to evaluate its safety.",[93,94],"Pleural Diseases","Pleural Effusion","2026-04-11",{"date":97,"type":98},"2026-04-15","ACTUAL",{"date":100,"type":98},"2025-03-11",{"date":102,"type":87},"2027-05",{"name":5,"class":6},1]