[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619479":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":52,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":10,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":79,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"University of Monastir","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Integrated LUS-Lactate Risk Group",null,"Patients classified according to a combined assessment of pulmonary congestion measured by lung ultrasound (LUS) and systemic tissue perfusion reflected by blood lactate levels at hospital discharge, aiming to capture both residual congestion and microcirculatory dysfunction and to improve prediction of early adverse outcomes.",[13,14],"Diagnostic Test: Lung Ultrasound Score","Diagnostic Test: Lactate Blood Test",[16,21],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"DIAGNOSTIC_TEST","Lung Ultrasound Score","A semi-quantitative ultrasound-based measure of pulmonary congestion that estimates interstitial and alveolar edema by counting B-lines across predefined lung zones, providing a simple and reproducible assessment of residual pulmonary congestion in heart failure patients.",[9],{"type":17,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Lactate Blood Test","A biochemical marker reflecting the balance between tissue oxygen delivery and consumption, with elevated levels indicating impaired tissue perfusion or increased anaerobic metabolism, and associated with worse outcomes in acute heart failure even in the absence of overt shock.",[9],[26],{"name":27,"affiliation":28,"role":29},"Semir Nouira, Professor","LR12SP18 ,University of Monastir","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"Semir Nouira Nouira, Professor","CONTACT","+216 73 106 046","semir.nouira.urg@gmail.com",[37],{"facility":38,"status":10,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Fattouma Bourguiba Hospital of Monastir","Monastir","Monastir Governorate","5000","Tunisia","TN",{"type":45,"coordinates":46},"Point",[47,48],10.82617,35.77799,{"lat":48,"lon":47},[51],{"name":27,"role":33,"phone":34,"phoneExt":10,"email":35},{"type":29,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Pr. Semir Nouira","Professor","100619479","congestion-and-lactate-at-discharge-in-acute-heart-failure-100619479",false,"NCT07345156","Congestion and LActate at diScHarge in Acute Heart Failure","Validation of a Combined Score Combining the Lung Ultrasound Score and Lactate at Discharge for Predicting Early Events After Acute Heart Failure","CLASH-HF","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Hospitalization for acute heart failure\u002Fdecompensation (clinical diagnosis + imaging\u002Flaboratory tests according to local practice).\n* Patient deemed ready for discharge (decision made by the team, discharge within 24 hours).\n\nExclusion Criteria:\n\n* Septic shock\u002Fsevere active infection at the time of discharge.\n* Hypoxemia or respiratory distress requiring high-flow oxygen\u002Fventilation at the scheduled time of discharge.\n* Severe cirrhosis\u002Fadvanced liver failure.\n* Refusal to participate.\n* Technical impossibility of LUS.","ALL","18 Years",{"count":66,"type":67},350,"ESTIMATED","OBSERVATIONAL","Acute heart failure (AHF) is a leading cause of hospitalization and is associated with high short-term morbidity and mortality, with 20-30% of patients experiencing rehospitalization or death within 30 days. Early adverse events often reflect incomplete recovery, highlighting the need for improved risk stratification after clinical stabilization .Current prognostic approaches mainly focus on hemodynamic congestion. Persistent pulmonary congestion at discharge is a strong predictor of poor outcomes, but these markers primarily assess macrocirculatory abnormalities and do not capture microcirculatory dysfunction, which may persist despite apparent clinical improvement. Lung ultrasound, through the Lung Ultrasound Score (LUS), provides a validated assessment of pulmonary congestion and has demonstrated prognostic value in AHF. However, LUS does not reflect systemic tissue perfusion. In contrast, blood lactate is a robust marker of tissue hypoperfusion, and even mild elevations have been associated with worse outcomes in AHF. A combined score integrating LUS and lactate may therefore better reflect the dual pathophysiology of AHF-persistent congestion and impaired tissue perfusion-and improve prediction of early adverse events.\n\nThis protocol aims to validate the prognostic value of this combined score for predicting 30-day rehospitalization or death in patients hospitalized for AHF, with the hypothesis that it outperforms LUS alone.",[71,72,73],"Heart Failure Acute","Discharge Follow-up Phone Calls","Mortality Prediction",[18,75,76,77,78],"Lactate","Combined score","Acute Heart Failure","Discharge","NOT_YET_RECRUITING","2026-01-08",{"date":82,"type":83},"2026-01-15","ACTUAL",{"date":85,"type":67},"2026-01-01",{"date":87,"type":67},"2026-12-30",{"name":5,"class":6},1]