[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571983":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":28,"locations":38,"responsibleParty":77,"collaborators":11,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":11,"eligibilityCriteria":86,"healthyVolunteers":82,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":11,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":40,"whyStopped":11,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"European University Cyprus","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Brace and BFR exercise","EXPERIMENTAL",null,[13,14],"Other: Blood Flow Restriction","Other: Brace",{"label":16,"type":17,"description":11,"interventionNames":18},"Brace and BFR sham","SHAM_COMPARATOR",[14],[20,24],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"Blood Flow Restriction","Exercise with restriction of blood flow supply",[9],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Brace","Knee brace to restrict range of motion",[9,16],[29,34],{"name":30,"role":31,"phone":32,"phoneExt":11,"email":33},"Alexis N Pitsillides, PhD candidate","CONTACT","0035799418065","alexpitsillides@gmail.com",{"name":35,"role":31,"phone":36,"phoneExt":11,"email":37},"Christos Karagiannis, PhD","0035799912547","C.Karayiannis@euc.ac.cy",[39,56],{"facility":5,"status":40,"city":41,"state":11,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Nicosia","2404","Cyprus","CY",{"type":46,"coordinates":47},"Point",[48,49],33.35397,35.17284,{"lat":49,"lon":48},[52],{"name":53,"role":31,"phone":54,"phoneExt":11,"email":55},"Marios Vryonides, Vice Vector","+35722713112","M.Vryonides@euc.ac.cy",{"facility":5,"status":40,"city":41,"state":11,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":57,"geoPoint":59,"contacts":60},{"type":46,"coordinates":58},[48,49],{"lat":49,"lon":48},[61,64,67,70,71,73,75],{"name":62,"role":31,"phone":63,"phoneExt":11,"email":55},"Marios Vryonides, Vice-Rector","0035722713112",{"name":65,"role":66,"phone":11,"phoneExt":11,"email":11},"Alexis Pitsillides, Phd candidate","PRINCIPAL_INVESTIGATOR",{"name":68,"role":69,"phone":11,"phoneExt":11,"email":11},"Antonis Konstantinou, Phd","SUB_INVESTIGATOR",{"name":35,"role":66,"phone":11,"phoneExt":11,"email":11},{"name":72,"role":66,"phone":11,"phoneExt":11,"email":11},"Konstantinos Giannakou, PhD",{"name":74,"role":69,"phone":11,"phoneExt":11,"email":11},"Kyriakos Pavlou, PhD candidate",{"name":76,"role":69,"phone":11,"phoneExt":11,"email":11},"Theognosia Panteli, PhD Cand",{"type":66,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Alexios Pitsillides","Alexios Pitsillides BSc, MSc, PhD (cand)","100571983","conservative-treatment-with-blood-flow-restriction-in-patients-with-total-acl-rupture-randomized-clinical-trial-100571983",false,"NCT06727344","Conservative Treatment With Blood Flow Restriction in Patients With Total ACL Rupture. \"Randomized Clinical Trial\"","Comparison of Conservative Treatment With Blood Flow Restriction With Standard Management in Total ACL Rupture. \"Randomized Clinical Trial\"","Inclusion Criteria:\n\n* MRI-confirmed complete rupture of ACL. Ability to communicate and read fluently in Greek and be willing to keep their leg immobilised for the required period based on the study protocol.\n\nExclusion Criteria:\n\n* Heart disease, overweight, diabetes, pregnancy, thrombophilia, atrial fibrillation, heart failure, cancer, use of drugs that may increase blood clotting, use of hormones or contraceptives, any reason for not using BFR e.g., an open wound or serious skin problems and\u002For allergies to the cuff material.","ALL","18 Years","40 Years",{"count":91,"type":92},20,"ESTIMATED","INTERVENTIONAL",[95],"NA","The goal of this randomised clinical trial is to evaluate the effects of exercise with blood flow restriction (BFR) in patients with a complete anterior cruciate ligament (ACL) rupture.\n\nThe main questions it aims to answer are:\n\n1. Does blood flow restriction adds any additional benefits to conservative treatment of the ACL?\n2. Does bracing promotes spontaneous healing to the ACL\n\nResearchers will compare bracing and BFR to bracing and sham BFR to see if the intervention provides any additional benefits to the conservative management of this injury.\n\nParticipants will:\n\n1. Use a knee brace for 6 weeks with adjustments according to protocol\n2. Follow and identical exercise plan with either BFR (intervention group) or BFR sham (control group)\n3. Follow a home based exercise program.",[98,99],"ACL","ACL - Anterior Cruciate Ligament Rupture",[101,21,25,102,98],"BFR","ACL rupture","2025-03-29",{"date":105,"type":106},"2025-04-03","ACTUAL",{"date":108,"type":106},"2025-02-01",{"date":110,"type":92},"2025-09",{"name":5,"class":6},2]