[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100511868":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":34,"centralContacts":38,"locations":49,"responsibleParty":66,"collaborators":10,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":10,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Guy's and St Thomas' NHS Foundation Trust","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Symptomatic pleural effuion",null,"Patients with symptomatic unilateral pleural effusion of any cause who will be undergoing pleural fluid removal via thoracocentesis, chest drain insertion or IPC drainage for relief of their breathlessness.",[13,14,15,16],"Other: Surface parasternal eletromyogram","Other: Surface diaphragm electromyogram","Other: Parasternal muscle ultrasound","Other: Breathlessness assessment",[18,22,26,30],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"Surface parasternal eletromyogram","The surface parasternal EMG of participants will be measured pre, immediately post and at days 1 and 7 following pleural fluid removal",[9],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"Surface diaphragm electromyogram","The ipsilateral and contralateral surface diaphragm EMG of participants will be measured pre and immediately post pleural fluid removal",[9],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Parasternal muscle ultrasound","The thickness of the parasternal intercostal muscle of participants will be measured using thoracic ultrasound pre and immediately post pleural fluid removal",[9],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"Breathlessness assessment","The VAS breathlessness score and Dyspnoea-12 questionnaire of participants will be measured pre, immediately post and at days 1 and 7 following pleural fluid removal",[9],[35],{"name":36,"affiliation":5,"role":37},"Patrick Murphy, MBBS BSc","PRINCIPAL_INVESTIGATOR",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Junyi Zhang, MBBChir","CONTACT","02071887188","56122","junyi.zhang@gstt.nhs.uk",{"name":46,"role":41,"phone":47,"phoneExt":10,"email":48},"Gillian Radcliffe","02071888070","gillian.radcliffe@gstt.nhs.uk",[50],{"facility":51,"status":52,"city":53,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Guy's & St Thomas' NHS Foundation Trust","RECRUITING","London","SE1 9RT","United Kingdom","UK",{"type":58,"coordinates":59},"Point",[60,61],-0.12574,51.50853,{"lat":61,"lon":60},[64],{"name":65,"role":41,"phone":47,"phoneExt":10,"email":48},"Gill Radcliffe",{"type":67,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100511868","continuation-of-a-study-to-investigate-the-effect-of-thoracocentesis-on-neural-respiratory-drive-in-pleural-effusion-100511868",false,"NCT05945043","Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion","Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion (COSINE)","COSINE","Inclusion Criteria:\n\n* Age 18 years or above\n* Has a unilateral pleural effusion AND\n\n  1. require thoracocentesis OR\n  2. chest drain insertion (main study only) OR\n  3. has an IPC in situ (main study only)\n\nExclusion Criteria:\n\n* Inability to consent\n* Any contraindications to the proposed pleural procedure\n* Haemodynamic or clinical instability that precludes from the safe completion of required pre-procedural measurements\n* Inability to identify surface landmarks for surface EMG electrode placement\n* Past medical history of diaphragmatic paralysis (diaphragm sub study only)","ALL","18 Years",{"count":79,"type":80},124,"ESTIMATED","OBSERVATIONAL","The aim of this study is to better understand the relationship between pleural effusions and breathlessness in patients with unilateral pleural effusions and breathlessness who require pleural fluid removal for its management.",[84],"Pleural Effusion",[86,87,88,89],"Pleural effusion","Breathlessness","Neural respiratory drive","Neurophysiology","2026-06-03",{"date":92,"type":93},"2026-06-04","ACTUAL",{"date":95,"type":93},"2023-11-15",{"date":97,"type":80},"2027-06-30",{"name":5,"class":6},1]