[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595407":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":37,"collaborators":20,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":41,"sex":47,"minAge":48,"maxAge":20,"enrollmentInfo":49,"targetDuration":20,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":65,"whyStopped":20,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Shin Kong Wu Ho-Su Memorial Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"CPM Intervention Group","EXPERIMENTAL","All participants received continuous passive motion (CPM) therapy on the left ankle once daily for seven consecutive days during mechanical ventilation. The right ankle, which did not receive CPM, served as the within-subject control. This single-arm trial employed a within-subject controlled design to allow direct comparison between the treated and untreated limbs in the same individual.",[13],"Device: Continuous Passive Motion",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Continuous Passive Motion","Continuous passive motion was applied to the left ankle joint for 30 minutes twice a day using a motorized CPM device.",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"CHEN-CHUN LIN, MD","CONTACT","+886960032062","m002186@ms.skh.org.tw",[28],{"facility":29,"status":20,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":20,"geoPoint":20,"contacts":35},"Shin Kong Wu Ho-su Memorial Hospital","Taipei City","Taipei","116","Taiwan","TW",[36],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},{"type":38,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100595407","continuous-passive-motion-to-prevent-ankle-contracture-and-muscle-atrophy-in-ventilated-patients-100595407",false,"NCT07032051","Continuous Passive Motion to Prevent Ankle Contracture and Muscle Atrophy in Ventilated Patients","Preventive Effects of Continuous Passive Motion on Ankle Contracture and Muscle Atrophy in Mechanically Ventilated Patients: A Pilot Study","CPM-ICU","Inclusion Criteria:\n\n\\- Eligible participants were adults (≥18 years) with acute respiratory failure expected to require mechanical ventilation for \\>5 days.\n\nExclusion Criteria:\n\n* Neuromuscular disorders\n* Recent lower limb surgery or trauma\n* Critical limb ischemia\n* Limb amputation\n* Deep vein thrombosis\n* Significant leg wounds\n* Pregnancy.","ALL","18 Years",{"count":50,"type":51},20,"ESTIMATED","INTERVENTIONAL",[54],"NA","This clinical trial aims to evaluate whether continuous passive motion (CPM) can prevent ankle joint contracture and muscle atrophy in critically ill patients receiving mechanical ventilation in the ICU. The study will also assess the feasibility and safety of implementing CPM therapy in this population.\n\nThe primary objectives are:\n\nTo determine whether CPM preserves ankle dorsiflexion range of motion during ICU immobilization.\n\nTo assess whether ultrasound can detect changes in tibialis anterior muscle morphology in response to CPM.\n\nIn this within-subject design, each participant will receive CPM therapy on one ankle while the contralateral ankle serves as the control. Outcomes related to joint mobility and muscle condition will be compared between the two sides.\n\nParticipants will:\n\nReceive CPM treatment on one ankle for 30 minutes, twice daily, for up to 7 days or until ICU discharge.\n\nUndergo goniometric and ultrasound assessments at baseline and after the intervention.\n\nContinue to receive standard ICU care throughout the study period.",[57,58,59],"Ankle Contracture","Critically Ill Intensive Care Unit Patients","Muscle Atrophy",[61,62,63,64],"ICU-acquired weakness","muscle ultrasound","ankle contracture","continuous passive motion,","NOT_YET_RECRUITING","2025-06-26",{"date":68,"type":69},"2025-06-29","ACTUAL",{"date":71,"type":51},"2025-06-25",{"date":73,"type":51},"2025-12-31",{"name":5,"class":6},1]