[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634338":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":30,"responsibleParty":85,"collaborators":18,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":91,"sex":97,"minAge":98,"maxAge":18,"enrollmentInfo":99,"targetDuration":18,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":50,"whyStopped":18,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Universitätsklinikum Hamburg-Eppendorf","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Continuous Norepinephrine Administration","EXPERIMENTAL","In patients assigned to continuous norepinephrine administration, norepinephrine will be administered continuously via a syringe infusion pump.",[13],"Procedure: Continuous Norepinephrine Administration",{"label":15,"type":16,"description":17,"interventionNames":18},"Bolus Norepinephrine Administration","NO_INTERVENTION","In patients assigned to manual bolus norepinephrine administration, norepinephrine will be given manually in bolus doses.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"PROCEDURE","In patients assigned to continuous administration of norepinephrine, a syringe infusion pump will be prepared and connected to a peripheral or central venous catheter. The responsible anesthesiologist will start the norepinephrine infusion and adjust the infusion rate as necessary and may administer additional norepinephrine boluses via the syringe infusion pump if required.",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Kristen K Thomsen, MD","CONTACT","+4940741070215","kr.thomsen@uke.de",[31,48,62,72],{"facility":32,"status":33,"city":34,"state":18,"zip":18,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin","NOT_YET_RECRUITING","Berlin","Germany","DE",{"type":38,"coordinates":39},"Point",[40,41],13.41053,52.52437,{"lat":41,"lon":40},[44],{"name":45,"role":27,"phone":46,"phoneExt":18,"email":47},"Sascha Treskatsch, MD","+49 30 450 551 522","sascha.treskatsch@charite.de",{"facility":49,"status":50,"city":51,"state":18,"zip":18,"country":35,"countryCode":36,"cosmosGeoPoint":52,"geoPoint":56,"contacts":57},"Department of Anesthesiology, University Hospital Duesseldorf, Heinrich Heine University Duesseldorf","RECRUITING","Düsseldorf",{"type":38,"coordinates":53},[54,55],6.77927,51.22319,{"lat":55,"lon":54},[58],{"name":59,"role":27,"phone":60,"phoneExt":18,"email":61},"Sebastian Roth, MD","+49 211 81 16253","Sebastian.Roth@med.uni-duesseldorf.de",{"facility":63,"status":50,"city":64,"state":18,"zip":18,"country":35,"countryCode":36,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf","Hamburg",{"type":38,"coordinates":66},[67,68],9.99302,53.55073,{"lat":68,"lon":67},[71],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},{"facility":73,"status":50,"city":74,"state":18,"zip":18,"country":35,"countryCode":36,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Department of Anaesthesiology, University Hospital LMU Munich","München",{"type":38,"coordinates":76},[77,78],13.31243,51.60698,{"lat":78,"lon":77},[81],{"name":82,"role":27,"phone":83,"phoneExt":18,"email":84},"Agnes Meidert, MD","+49 89 440081065","Agnes.meidert@med.uni-muenchen.de",{"type":86,"investigatorFullName":87,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Kristen Thomsen","Principal Investigator","100634338","continuous-versus-bolus-norepinephrine-administration-to-treat-postinduction-hypotension-100634338",false,"NCT07538388","Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension","Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension in High-Risk Non-Cardiac Surgery Patients - The Multicenter INDUCT Trial (INDUCT-Multi)","INDUCT-Multi","Inclusion Criteria:\n\nWe will include consenting patients ≥45 years scheduled for elective non-cardiac surgery under general anesthesia with planned continuous intra-arterial blood pressure monitoring with a radial arterial catheter and with at least two of the following risk criteria for developing acute kidney injury:\n\n* Age ≥65 years\n* ASA physical status III or IV\n* Chronic arterial hypertension\n* Diabetes mellitus requiring medication\n* Intra-abdominal surgery\n* Preoperative renal insufficiency (serum creatinine ≥1.2 mg\u002FdL)\n\nExclusion Criteria:\n\n* Pregnancy\n* Cardiac arrhythmia\n* History of intracranial hemorrhage or intracranial aneurysm\n* Clinical indication for continuous norepinephrine infusion during induction of general anesthesia (e.g., severe aortic valve stenosis, coronary artery disease, or heart failure)\n* Patients who are unable to understand, read, and provide informed consent in German","ALL","45 Years",{"count":100,"type":101},446,"ESTIMATED","INTERVENTIONAL",[104],"NA","INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.",[107],"Postinduction Hypotension",[109,110,111,112,113,114],"postinduction hypotension","non-cardiac surgery","norepinephrine","bolus","hypotension","continuous","2026-06-24",{"date":117,"type":118},"2026-06-29","ACTUAL",{"date":120,"type":118},"2026-05-07",{"date":122,"type":101},"2026-12",{"name":5,"class":6},4]