[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100528802":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":43,"responsibleParty":63,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":25,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":92,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Barts & The London NHS Trust","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Convergent AF Ablation with Left Atrial Appendage Exclusion","EXPERIMENTAL","Two Staged Convergent AF Ablation Procedure\n\nStage 1 - Minimally Invasive Surgical Epicardial Ablation Procedure with concomitant LAA exclusion (LARIAT procedure)\n\nStage 2 - Percutaneous Endocardial Catheter Ablation",[13,14],"Device: Epicardial AF ablation using AtriCure EPi-Sense-AF Guided Coagulation System with Left Atrial Appendage Exclusion using the AtriCure LARIAT Suture Delivery Device.","Procedure: Standard Endocardial Catheter Ablation",{"label":16,"type":17,"description":16,"interventionNames":18},"Standard Endocardial Catheter Ablation","ACTIVE_COMPARATOR",[14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Epicardial AF ablation using AtriCure EPi-Sense-AF Guided Coagulation System with Left Atrial Appendage Exclusion using the AtriCure LARIAT Suture Delivery Device.","2 stage procedure - minimally-invasive epicardial ablation with left atrial appendage exclusion using LARIAT procedure via a subxiphoid incision. This is then combined with endocardial radiofrequency catheter ablation in a separate staged procedure.",[9],null,{"type":27,"name":16,"description":28,"armGroupLabels":29,"otherNames":25},"PROCEDURE","Standard percutaneous endocardial catheter ablation of atrial fibrillation",[9,16],[31],{"name":32,"affiliation":33,"role":34},"Syed Ahsan","Consultant Cardiologist and Electrophysiologist, Barts Health NHS Trust","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","020 7377 7000","syedahsan@nhs.net",{"name":41,"role":37,"phone":38,"phoneExt":25,"email":42},"Shahana Hussain","shahana.hussain2@nhs.net",[44],{"facility":45,"status":46,"city":47,"state":25,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"St Bartholomew's Hospital","RECRUITING","London","EC1A 4AS","United Kingdom","UK",{"type":52,"coordinates":53},"Point",[54,55],-0.12574,51.50853,{"lat":55,"lon":54},[58,59,60],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},{"name":32,"role":34,"phone":25,"phoneExt":25,"email":25},{"name":61,"role":62,"phone":25,"phoneExt":25,"email":25},"Nikolaos Papageorgiou","SUB_INVESTIGATOR",{"type":64,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[66],{"name":67,"class":68},"AtriCure, Inc.","INDUSTRY","100528802","convergent-ablation-plus-left-atrial-appendage-isolation-for-the-treatment-of-persistent-atrial-fibrillation-100528802",false,"NCT06165510","Convergent Ablation Plus Left Atrial Appendage Isolation for the Treatment of Persistent Atrial Fibrillation","CLIP-AF","Inclusion Criteria:\n\n* Age \\> 18 years; \\\u003C 80 years\n* Persistent AF \\> 1-year duration\n* Left atrium size \\\u003C 6cm\n* Pts should be able to provide written informed consent.\n\nExclusion Criteria:\n\n* Subjects currently enrolled in another investigational study except in case of observational registry with no associated treatments.\n* Subject has a reversible cause of AF or transient AF\n* Subject is absent of LAA or if the LAA is previously surgically ligated\n* Subject has had previous cardiac surgery or abdominal surgery.\n* Subject has contraindication to anticoagulation.\n* Patients with hypertrophic cardiomyopathy.\n* Patients with significant valve disease.\n* Subject has had previous catheter or surgical ablation",true,"ALL","18 Years","80 Years",{"count":81,"type":82},48,"ESTIMATED","INTERVENTIONAL",[85],"NA","A randomised controlled clinical trial to assess efficacy of convergent ablation with the LARIAT procedure, as compared to standard endocardial catheter ablation in patients with long-standing persistent atrial fibrillation (AF).",[88,89,90,91],"Persistent Atrial Fibrillation","Atrial Fibrillation, Persistent","Atrium; Fibrillation","Atrial Arrhythmia",[93,94,95,96,97],"Catheter ablation","Convergent procedure","Left atrial appendage","Hybrid ablation","Cardiac arrhythmias","2026-06-24",{"date":100,"type":101},"2026-06-25","ACTUAL",{"date":103,"type":101},"2024-08-02",{"date":105,"type":82},"2026-11",{"name":5,"class":6},1]