[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592127":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":12,"locations":18,"responsibleParty":36,"collaborators":7,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":7,"enrollmentInfo":49,"targetDuration":7,"studyType":52,"phases":7,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"University of Modena and Reggio Emilia","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"This is an observational study. Interventions are standard of care and include: High-flow nasal oxygen (HFNO) Non-invasive ventilation (NIV) Pnose monitoring","No experimental interventions are administered as part of the study.",[13],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Roberto Tonelli, MD, PhD","CONTACT","+390594225934","rtonelli@unimore.it",[19],{"facility":20,"status":21,"city":22,"state":7,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"AOU Policlinico di Modena","RECRUITING","Modena","41125","Italy","IT",{"type":27,"coordinates":28},"Point",[29,30],10.92539,44.64783,{"lat":30,"lon":29},[33],{"name":34,"role":15,"phone":35,"phoneExt":7,"email":17},"Roberto Tonelli, MD","0039 0594225934",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Roberto Tonelli","Assistant Professor","100592127","coraline---correlation-between-physiological-and-clinical-variables-and-failure-of-non-invasive-respiratory-support-in-patients-with-acute-respiratory-failure-100592127",false,"NCT06989385","CORALINE - Correlation Between Physiological and Clinical Variables and Failure of Non-Invasive Respiratory Support in Patients With Acute Respiratory Failure","CORALINE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Hospitalization in the Respiratory Medicine Unit at AOU Policlinico di Modena\n* Acute respiratory failure (hypoxemic and\u002For hypercapnic) with PaO₂\u002FFiO₂ \\\u003C 300 mmHg\n* Undergoing treatment with HFNO or NIV\n\nExclusion Criteria:\n\n* Immediate need for invasive ventilation upon admission\n* Known neuromuscular disease\n* Pregnancy\n* Lack of informed consent","ALL","18 Years",{"count":50,"type":51},325,"ESTIMATED","OBSERVATIONAL","This observational study aims to evaluate the relationship between clinical and physiological variables and the failure of non-invasive respiratory support (NIRS), including high-flow nasal oxygen (HFNO) and non-invasive ventilation (NIV), in patients with acute respiratory failure (ARF), both hypoxemic and\u002For hypercapnic. The study includes both retrospective and prospective components. Retrospective data will be collected from patient charts, while prospective data will be collected at defined time points during clinical care. The primary outcome is NIRS failure, defined as the need for orotracheal intubation. Secondary outcomes include in-hospital and 90-day mortality, ICU and hospital length of stay, and duration of non-invasive and invasive support.",[55],"Acute Respiratory Failure",[57,58,59,60],"Acute respiratory failure","High flow nasal cannula","Non-invasive ventilation","Inspiratory effort","2026-01-19",{"date":63,"type":64},"2026-01-22","ACTUAL",{"date":66,"type":64},"2024-11-01",{"date":68,"type":51},"2030-01-01",{"name":5,"class":6},1]