[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100347363":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":45,"collaborators":7,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":7,"studyType":61,"phases":7,"briefSummary":62,"conditions":63,"keywords":7,"overallStatus":31,"whyStopped":7,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"PROCEDURE","CB transplantation","Myeloablative conditioning with post-transplant cyclophosphamide in patients receiving a matched CB transplant for hematological malignancies.",[14],"Myeloablative conditioning and post-transplant cyclophosphamide",[16],{"name":17,"affiliation":5,"role":18},"Patrizia Chiusolo, MD","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":7,"email":24},"Andrea Bacigalupo, Prof.","CONTACT","0630154180","andrea.bacigalupo@unicatt.it",{"name":17,"role":22,"phone":26,"phoneExt":7,"email":27},"0630156244","patrizia.chiusolo@unicatt.it",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Fondazione Policlinico Universitario A. Gemelli IRCCS","RECRUITING","Roma","RM","00168","Italy","IT",{"type":38,"coordinates":39},"Point",[40,41],11.10642,44.99364,{"lat":41,"lon":40},[44],{"name":21,"role":22,"phone":23,"phoneExt":7,"email":24},{"type":46,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100347363","cord-blood-transplantation-with-myeloablative-conditioning-and-post-transplant-cyclophosphamide-compact-study-100347363",false,"NCT03802773","Cord Blood Transplantation With Myeloablative Conditioning and Post-transplant Cyclophosphamide (COmPACt Study)","Cord Blood Transplantation With Myeloablative Conditioning and Post-transplant Cyclophosphamide in Patients With Hematological Malignancies (The COmPACt Study)","COmPACt","Inclusion Criteria:\n\n* Age: ≥ 18 ≤ 75 years old\n* CB unit transplantation (TNC\\> 2,0 x10\\^7\u002Fkg and \\> 4\u002F6 loci HLA matched)\n* Myeloablative conditioning regimen consisting of either Thiotepa\u002F Busulfan\u002F Fludarabine or TBI\u002F Fludarabine\n* GVHD prophylaxis including PT-Cy (30 mg\u002Fkg or more on days + 3and +5) CSA and MMF\n* Diagnosis of 1 of the following hematological malignancies: Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome, high risk Acute Lymphoblastic Leukemia (ALL), Bi phenotypic\u002Fundifferentiated leukemia, Chronic Myeloid Leukemia resistant to TK inhibitors, Ph-neg Myeloproliferative Neoplasms, resistant\u002Frelapsing Non-Hodgkin's lymphoma ineligible for an autologous transplant.\n\nExclusion Criteria:\n\n* Positive serologic markers for human immunodeficiency virus (HIV)\n* Acute hepatitis B virus (HBV) or acute hepatitis C virus (HCV) infection","ALL","18 Years","75 Years",{"count":59,"type":60},10,"ESTIMATED","OBSERVATIONAL","Despite anti-thymocyte globulin has a mainstay role in preventing GvHD (and non-relapse mortality) in CB transplantation, it also induces delayed immune recovery, increased risk of cytomegalovirus and Epstein-Barr virus reactivation, post-transplant lymphoproliferative diseases, overall accounting for increased transplant-related mortality and\u002For increased relapse incidence. All these findings support the use of alternative approaches for in vivo T cell depletion in the setting of CB transplantation.",[64,65],"Cord Blood Transplantation","Hematological Malignancies","2025-04-07",{"date":68,"type":69},"2025-04-09","ACTUAL",{"date":71,"type":69},"2019-03-14",{"date":73,"type":60},"2025-12-31",{"name":5,"class":6},1]