[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100529189":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":41,"responsibleParty":60,"collaborators":62,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":26,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":26,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Johns Hopkins University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"UHR-CT (Ultra-High-Resolution Computed Tomography-Aquilion Precision)","EXPERIMENTAL","Participants in this arm undergo CT scans using the Ultra-High-Resolution CT imaging modality.",[13],"Device: Aquilion Precision",{"label":15,"type":16,"description":17,"interventionNames":18},"CR-CT (Conventional Resolution Computed Tomography)","ACTIVE_COMPARATOR","Participants in this arm receive CT scans using the Conventional Resolution CT imaging modality.",[19],"Device: Conventional Computed Tomography",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Aquilion Precision","Ultra-High Resolution CT (UHR CT) capable of resolving anatomy as small as 150 microns, providing CT image quality with resolution typically seen only in cath labs. The UHR detector is newly designed to provide more than twice the resolution when compared with today's CT technology, with an all-new detector as well as tube, gantry and reconstruction technologies.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Conventional Computed Tomography","Conventional reconstruction Computed Tomography (CT) represents a pivotal approach in medical imaging.",[15],[32],{"name":33,"affiliation":34,"role":35},"Joao Lima, Professor","MD","PRINCIPAL_INVESTIGATOR",[37],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","4106141284","jlima@jhmi.edu",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Johns Hopkins School of Medicine","RECRUITING","Baltimore","Maryland","21205","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-76.61219,39.29038,{"lat":54,"lon":53},[57],{"name":58,"role":38,"phone":26,"phoneExt":26,"email":59},"Michelle lHughes-Lukoski","mhughe17@jh.edu",{"type":61,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[63],{"name":64,"class":65},"Canon Medical Systems, USA","INDUSTRY","100529189","core-compare-pilot-study-100529189",false,"NCT06170541","CORE-COMPARE Pilot Study","Ultra-High Resolution Computed Tomography (CT) vs. Conventional CT for Detecting Obstructive Coronary Artery Disease (CAD) The CORE-COMPARE Pilot Study","Inclusion Criteria:\n\n* Patients aged 21-85 years\n* Clinical history suggestive of CHD who are referred by their primary cardiologist for further evaluation via Computed tomography angiography (CTA) will be asked to participate.\n* Women of child bearing potential must demonstrate a negative pregnancy test within 24 hours of the study CTA.\n* Ability to understand and willingness to sign the Informed Consent Form.\n\nExclusion Criteria:\n\n* Known allergy to iodinated contrast media.\n* History of multiple myeloma or previous organ transplantation\n* Elevated serum creatinine (\\> 1.5mg\u002Fdl) OR calculated creatinine clearance of \\\u003C 60 ml\u002Fmin (using the Cockcroft-Gault formula\n* Atrial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block (second or third degree heart block)\n* Evidence of severe symptomatic heart failure (NYHA Class III or IV);\n* Known or suspected moderate or severe aortic stenosis\n* History of prior percutaneous coronary intervention (PCI) in one or more vessel or history of coronary arterial bypass grafting (CABG)\n* Suspected acute coronary syndrome\n* Presence of any other history or condition that the investigator feels would be problematic","ALL","21 Years","85 Years",{"count":77,"type":78},140,"ESTIMATED","INTERVENTIONAL",[81],"NA","The utility of Ultra High-Resolution Computed Tomography (UHR-CT) compared to conventional CT in all-comers (i.e., a generally lower-risk population) remains uncertain but is an important area of study in order to justify wider spread implementation and use of this technology, particularly in light of reports of significantly higher radiation exposure with UHR-CT, as well as longer scan times. The availability of technology to reconstruct conventional resolution (CR) simulation images from the raw CT acquisition data acquired on the UHR-CT scanner offers a unique platform to study this question without subjecting individuals to two different scans.\n\nThe primary objective of this study is to generate preliminary data in support of the hypothesis that noninvasive UHR-CT is superior to conventional resolution CT for identifying patients with obstructive CHD.",[84],"Coronary Heart Disease (CHD)","2026-04-08",{"date":87,"type":88},"2026-04-13","ACTUAL",{"date":90,"type":88},"2021-04-05",{"date":92,"type":78},"2027-12",{"name":5,"class":6},1]