[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590768":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":24,"centralContacts":32,"locations":38,"responsibleParty":56,"collaborators":58,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":10,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":10,"enrollmentInfo":70,"targetDuration":10,"studyType":73,"phases":10,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of East Anglia","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Drug eluted stent",null,[12],"Diagnostic Test: Optical coherence tomography and pressure wire assessment of the vessel treated before and after treatment",{"label":14,"type":10,"description":10,"interventionNames":15},"Drug coated balloon",[12],[17],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DIAGNOSTIC_TEST","Optical coherence tomography and pressure wire assessment of the vessel treated before and after treatment","OCT and pressure wire of the main vessel and side branch of the bifurcation are undertaken prior to and after treating the lesion and at 3-9 month follow up.",[14,9],[23],"Optical coherence tomography",[25,29],{"name":26,"affiliation":27,"role":28},"Vassilios S Vassiliou","Norwich Medical School","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":31,"role":28},"Simon C Eccleshall","Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK)",[33],{"name":34,"role":35,"phone":36,"phoneExt":10,"email":37},"Natasha Corballis, MBBS, MRCP (UK), MSc","CONTACT","01603286286","natasha.corballis@nnuh.nhs.uk",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Norwich Medical School, University of East Anglia","RECRUITING","Norwich","Norfolk","NR47TJ","United Kingdom","UK",{"type":48,"coordinates":49},"Point",[50,51],1.29834,52.62783,{"lat":51,"lon":50},[54],{"name":55,"role":35,"phone":36,"phoneExt":10,"email":37},"Natasha Corballis",{"type":57,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[59],{"name":60,"class":6},"Norfolk and Norwich University Hospitals NHS Foundation Trust","100590768","coronary-bifurcations-with-ischaemia-and-flow-assessment-100590768",false,"NCT06971718","Coronary Bifurcations With Ischaemia and Flow Assessment","Drug Coated Balloons in Coronary Bifurcation Lesions. A Feasibility Study Looking at Computational Flow Dynamics, Ischaemic and Anatomical Changes to the Bifurcation","Inclusion Criteria:\n\n* Age 18 or over\n* Any bifurcation lesion amenable to a provisional main vessel treatment strategy\n* A main vessel diameter of 2.5mm or more and side branch diameter of \\>2mm\n* Any patient with stable angina, silent ischaemia, unstable angina or NSTEMI\n* Able to give informed consent\n\nExclusion Criteria:\n\n* Cardiogenic shock\n* LVEF \\\u003C30%\n* STEMI (as unable to give informed consent)\n* eGFR \\\u003C30\n* Severe asthma contraindicating use of adenosine\n* High degree AV block on 12 lead ECG precluding the use of adenosine\n* Pregnancy\n* Inability to consent\n* Left main stem coronary bifurcation lesions","ALL","18 Years",{"count":71,"type":72},24,"ESTIMATED","OBSERVATIONAL","The coronary arteries are blood vessels that provide oxygen rich blood to the muscle of the heart. If these vessels become narrowed or blocked, this can lead to chest pain (called angina) or heart attacks. Narrowings are usually treated using metal scaffolds called drug eluting stents. However, in one in five cases where the narrowing occurs at a branching point, treating it with stents is more challenging and can cause complications. A possible alternative treatment is using a special type of balloon called a drug-coated balloon. This balloon is inflated in the blood vessel and releases medicine to help widen the blood vessel and the procedure is completed without leaving any metallic scaffold behind.\n\nThis study aims to compare drug coated balloons with drug eluting stents to see which treatment works better for narrowing that occurs at branching points. We will used advanced imaging techniques to create computer models of blood flow in the vessels, and we will follow up with patients over tie to see how well the treatments work.",[76],"Coronary Bifurcation Lesions",[78,79,80],"Drug coated balloons","Coronary bifurcation lesions","Computational flow dynamics","2025-05-06",{"date":83,"type":84},"2025-05-14","ACTUAL",{"date":86,"type":84},"2023-10-10",{"date":88,"type":72},"2026-06-01",{"name":5,"class":6},1]