[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603738":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":31,"responsibleParty":46,"collaborators":49,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":18,"enrollmentInfo":71,"targetDuration":18,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":86,"whyStopped":18,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Qilu Hospital of Shandong University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Arm","EXPERIMENTAL","Patients receive early coronary computed tomographic angiography (CCTA) combined with CT-derived fractional flow reserve (CT-FFR) to guide diagnostic and treatment decisions, in addition to standard care.",[13],"Diagnostic Test: Coronary computed tomographic angiography with CT - derived fractional flow reserve",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Arm","NO_INTERVENTION","Patients receive standard care without early CCTA, with further management determined at the discretion of their treating physician.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DIAGNOSTIC_TEST","Coronary computed tomographic angiography with CT - derived fractional flow reserve","A non-invasive coronary computed tomography angiography (CCTA) protocol that visualizes coronary anatomy to evaluate the presence, location, and severity of atherosclerotic stenosis, coupled with CT-derived fractional flow reserve (CT-FFR) analysis-a computational fluid dynamics method applied to CCTA datasets-to assess the hemodynamic significance of identified stenoses and identify lesions likely to induce myocardial ischemia.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Chuanbao Li","CONTACT","+86 18560083097","bao2460@126.com",[32],{"facility":27,"status":18,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Jinan","Shandong","250000","China","CN",{"type":39,"coordinates":40},"Point",[41,42],116.99722,36.66833,{"lat":42,"lon":41},[45],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},{"type":47,"investigatorFullName":27,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Clinical Professor",[50,52,54,56,59],{"name":51,"class":6},"The Affiliated Hospital of Qingdao University",{"name":53,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"name":55,"class":6},"Beijing Anzhen Hospital",{"name":57,"class":58},"JiNing NO.1 People Hospital","UNKNOWN",{"name":60,"class":58},"Zhun Ge Er Qi Central Hospital","100603738","coronary-computed-tomographic-angiography-combined-with-ct-ffr-in-intermediate-risk-chest-pain-patients-100603738",false,"NCT07140419","Coronary Computed Tomographic Angiography Combined With CT-FFR in Intermediate-Risk Chest Pain Patients.","A Prospective, Multicenter, Randomized Controlled Trial on the Impact of Coronary CTA Combined With CT-FFR on Diagnosis and Treatment Decisions and Clinical Outcomes in Emergency Patients With Intermediate Risk Chest Pain","E-CCTA","Inclusion Criteria:\n\n1. Age≥18 years；\n2. Within 24 hours of presenting to the emergency department (ED) with chest pain or other symptoms suggestive of coronary artery disease (CAD)；\n3. HEART-score \\>3 (according to http:\u002F\u002Fwww.heartscore.nl\u002F)；\n4. Signed written informed consent.\n\nExclusion Criteria:\n\n1. Inability to obtain informed consent；\n2. Acute Coronary Syndromes (ACS) requiring urgent revascularization；\n3. Known Obstructive Coronary Artery Disease (CAD) or previous PCI or CABG;\n4. Concomitant severe congestive heart failure (New York Heart Association \\[NYHA\\] class III-IV or left ventricular ejection fraction \\[LVEF\\] \\\u003C 30%) or acute pulmonary edema;\n5. Severe hepatic insufficiency (Child-Pugh score ≥ C, or aspartate aminotransferase \\[AST\\] \\> 5× upper limit of normal); severe renal insufficiency (estimated glomerular filtration rate \\[eGFR\\] ≤ 30 mL\u002Fmin\u002F1.73 m²) or patients receiving continuous renal replacement therapy, hemodialysis, or peritoneal dialysis;\n6. History of prior coronary artery bypass grafting (CABG);\n7. Severe allergy to iodinated contrast agents;\n8. Inability to obtain high-quality imaging;\n9. Pregnant or lactating females;\n10. Concomitant diseases or limited life expectancy, quality of life, or functional status precluding further CAD evaluation;\n11. Any other factors that, in the investigator's judgment, make the patient unsuitable for study enrollment, completion of the study, or follow-up.","ALL","18 Years",{"count":72,"type":73},2000,"ESTIMATED","INTERVENTIONAL",[76],"NA","This study aims to investigate the guiding value of coronary CTA combined with CT-FFR in diagnostic and treatment decision-making for emergency chest pain patients at moderate risk, as well as its impact on clinical outcomes. Through a prospective multicenter randomized controlled trial, this research compares the preventive effects of early application of this technology versus standard care on major adverse cardiovascular and cerebrovascular events (MACCE), with the goal of optimizing the diagnostic and treatment processes for emergency chest pain patients.",[79,80,81],"Chest Pain","Coronary Artery Disease","Emergency Department",[83,81,84,85,80],"Intermediate Risk Chest Pain","CCTA","CT-FFR","NOT_YET_RECRUITING","2026-03-18",{"date":89,"type":90},"2026-03-20","ACTUAL",{"date":92,"type":73},"2026-04-01",{"date":94,"type":73},"2032-06-30",{"name":5,"class":6},1]