[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503894":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":37,"locations":45,"responsibleParty":65,"collaborators":10,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":10,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":88,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Imperial College London","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Controls",null,"10 patients with unobstructed coronary arteries, normal microvascular function and normal LV function.",[13],"Diagnostic Test: Pressure and flow measurement during simulated VT",{"label":15,"type":10,"description":16,"interventionNames":17},"Coronary artery disease","25 patients with severe, single-vessel coronary artery disease of the proximal LAD or proximal other dominant vessel awaiting PCI.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Microvascular dysfunction","15 patients with without severe disease in any coronary artery, impaired microvascular function and normal LV function.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Heart failure","20 patients with LV systolic dysfunction (LVEF\\\u003C40%).",[13],[27],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":10},"DIAGNOSTIC_TEST","Pressure and flow measurement during simulated VT","Participants undergoing coronary angiography will have measurements of blood pressure, coronary pressure and coronary flow during simulated VT. VT will be simulated using pacing at a range of heart rates.",[9,15,23,19],[33],{"name":34,"affiliation":35,"role":36},"Ricardo Petraco","Senior Clinical Research Fellow","PRINCIPAL_INVESTIGATOR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":10,"email":42},"Rahul Bahl","CONTACT","+44 20 7594 1093","r.bahl@imperial.ac.uk",{"name":34,"role":40,"phone":41,"phoneExt":10,"email":44},"r.petraco@imperial.ac.uk",[46],{"facility":47,"status":48,"city":49,"state":10,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Imperial College NHS Foundation Trust","RECRUITING","London","W12 0HS","United Kingdom","UK",{"type":54,"coordinates":55},"Point",[56,57],-0.12574,51.50853,{"lat":57,"lon":56},[60,62,63],{"name":39,"role":40,"phone":61,"phoneExt":10,"email":42},"020 7594 5735",{"name":34,"role":40,"phone":61,"phoneExt":10,"email":44},{"name":64,"role":36,"phone":10,"phoneExt":10,"email":10},"Ricardo Petraco, PhD",{"type":66,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100503894","coronary-flow-during-rapid-heart-rates-100503894",false,"NCT05841199","Coronary Flow During Rapid Heart Rates","Coronary Epicardial and Microcirculatory Determinants of Ventricular Tachycardia Tolerability","VT flow","Inclusion Criteria:\n\n* Able to give valid consent\n* Referred for coronary angiography or coronary angioplasty\n* Suitable for percutaneous physiological interrogation and PCI when clinically indicated\n\nExclusion Criteria:\n\n* Unable to give valid consent\n* Pregnant or breastfeeding women\n* Unstable coronary artery disease (acute coronary syndrome)\n* Severe multivessel coronary artery disease suitable for coronary artery bypass grafting\n* Severe heart valve disease\n* Severe (NYHA IV) heart failure","ALL","18 Years",{"count":78,"type":79},70,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are:\n\n1. What impact does coronary artery disease have on the ability for a patient to tolerate VT?\n2. Does treatment of coronary artery disease with stents improve the tolerability of VT?\n\nParticipants who are undergoing a clinically indicated coronary angiogram or coronary angioplasty procedure will have measurements of blood pressure, coronary pressure and coronary flow made during pacing at a range of heart rates.",[83,84,85,86,87],"Ventricular Tachycardia","Coronary Artery Disease","Heart Failure","Coronary Microvascular Dysfunction","Coronary Microvascular Disease",[83,84,85,86,87,89,90],"Percutaneous Coronary Intervention","Implantable Cardioverter Defibrillator","2026-03-24",{"date":93,"type":94},"2026-03-27","ACTUAL",{"date":96,"type":94},"2023-08-01",{"date":98,"type":79},"2026-06-02",{"name":5,"class":6},1]