[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642956":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":27,"responsibleParty":44,"collaborators":11,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":11,"eligibilityCriteria":51,"healthyVolunteers":48,"sex":52,"minAge":53,"maxAge":11,"enrollmentInfo":54,"targetDuration":11,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":71,"whyStopped":11,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Odense University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Coronary thrombus modification","EXPERIMENTAL",null,[13],"Procedure: Coronary thrombus modification",{"label":15,"type":16,"description":11,"interventionNames":17},"Standard stent implantation","ACTIVE_COMPARATOR",[18],"Procedure: Standard stent implantation",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"PROCEDURE","Inflation of a short balloon not larger than the vessel size for 30 seconds following deflation for 30 seconds repeated a total of 4 times. Thereafter, patients will undergo standard stent implantation as per operator decision.",[9],{"type":21,"name":15,"description":25,"armGroupLabels":26,"otherNames":11},"Predilation before stent implantation will follow normal clinical guidelines, and to the discretion of the operator. patients will undergo standard stent implantation as per operator decision.",[15],[28],{"facility":5,"status":11,"city":29,"state":11,"zip":11,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Odense","Denmark","DK",{"type":33,"coordinates":34},"Point",[35,36],10.38831,55.39594,{"lat":36,"lon":35},[39],{"name":40,"role":41,"phone":42,"phoneExt":11,"email":43},"Jens Trøan, MD","CONTACT","+4565412690","jens.troan3@rsyd.dk",{"type":45,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100642956","coronary-thrombus-modification-to-prevent-microvascular-damage-in-patients-with-st-segment-elevation-myocardial-infarction-the-cormi-trial-100642956",false,"NCT07646977","CORonary Thrombus Modification to Prevent MIcrovascular Damage in Patients With ST-segment Elevation Myocardial Infarction (The CORMI Trial)","Inclusion Criteria:\n\n* ST-elevation at the J-junction in a minimum of two contiguous ECG leads with a minimum of ≥ 0.1 mV in all leads, except for V2 and V3 (which required ≥ 0.2 for men ≥ 40 years old, ≥ 0.25 in men \\\u003C 40 years old, or ≥ 0.15 mV for all women) or new left bundle branch\n* Admission to hospital within 12 hours of symptom debut\n* Angiographic signs of a culprit lesion planned to be treated with primary percutaneous coronary intervention\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years or inability to provide informed consent\n* Life expectancy of \\\u003C 12 months\n* Hemodynamically instability\n* Pregnancy or breastfeeding\n* Known asthma or severe chronic obstructive pulmonary disease\n* Expected inability to perform physiological measurements (due to severely tortuous arteries, ostial disease or very distal disease),\n* CMR contraindications (estimated glomerular filtration rate \\\u003C 30 mL\u002Fmin, magnetic or mechanically activated implants, or any prior metal implants, severe claustrophobia)\n* Expected to or unavoidable to use thrombectomy","ALL","18 Years",{"count":55,"type":56},100,"ESTIMATED","INTERVENTIONAL",[59],"NA","The aim of this study is to evaluate the effects of coronary thrombus modification on preventing the microvascular damage associated with primary percutaneous coronary intervention (PCI), and to limit the associated myocardial damage assessed by myocardial salvage index after 3 months. Furthermore, the project will evaluate coronary microvascular damage assessed invasively using both continuous and bolus thermodilution before and after stent implantation. In addition, the project will evaluate the diagnostic ability and associations of pre-stenting invasive physiological measurement to cardiac magnetic resonance imaging measurements.",[62,63,64],"ST Elevation Myocardial Infarction","Coronary Microvascular Dysfunction","Percutaneous Coronary Intervention",[66,67,68,69,70],"Microvascular damage","Continuous thermodilution","Bolus thermodilution","Myocardial damage","Cardiac MRI","NOT_YET_RECRUITING","2026-06-19",{"date":74,"type":75},"2026-06-24","ACTUAL",{"date":77,"type":56},"2026-06",{"date":79,"type":56},"2034-01",{"name":5,"class":6},1]