[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642286":3},{"organization":4,"armGroups":7,"interventions":45,"overallOfficials":10,"centralContacts":64,"locations":70,"responsibleParty":85,"collaborators":10,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":97,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":10,"studyType":103,"phases":10,"briefSummary":104,"conditions":105,"keywords":10,"overallStatus":110,"whyStopped":10,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Universitair Ziekenhuis Brussel","OTHER",[8,17,21,25,29,33,37,41],{"label":9,"type":10,"description":11,"interventionNames":12},"Follicle size 11mm",null,"Patients with a follicle of 11mm when measured through transvaginal ultrasound in 2D, at time of ovulation induction.",[13,14,15,16],"Diagnostic Test: Blood samples for the analysis of biomarkers.","Diagnostic Test: Transvaginal ultrasound for follicle and endometrium measurements.","Diagnostic Test: Mean Arterial Pressure measurement.","Drug: Ovitrelle injection for ovulation induction",{"label":18,"type":10,"description":19,"interventionNames":20},"Follicle size 12 mm","Patients with a follicle of 12mm when measured through transvaginal ultrasound in 2D, at time of ovulation induction.",[13,14,15,16],{"label":22,"type":10,"description":23,"interventionNames":24},"Follicle size 13 mm","Patients with a follicle of 13mm when measured through transvaginal ultrasound in 2D, at time of ovulation induction.",[13,14,15,16],{"label":26,"type":10,"description":27,"interventionNames":28},"Follicle size 14 mm","Patients with a follicle of 14mm when measured through transvaginal ultrasound in 2D, at time of ovulation induction.",[13,14,15,16],{"label":30,"type":10,"description":31,"interventionNames":32},"Follicle size 15 mm","Patients with a follicle of 15mm when measured through transvaginal ultrasound in 2D, at time of ovulation induction.",[13,14,15,16],{"label":34,"type":10,"description":35,"interventionNames":36},"Follicle size 16 mm","Patients with a follicle of 16mm when measured through transvaginal ultrasound in 2D, at time of ovulation induction.",[13,14,15,16],{"label":38,"type":10,"description":39,"interventionNames":40},"Follicle size 17 mm","Patients with a follicle of 17mm when measured through transvaginal ultrasound in 2D, at time of ovulation induction.",[13,14,15,16],{"label":42,"type":10,"description":43,"interventionNames":44},"Follicle size 18 mm","Patients with a follicle of 18mm when measured through transvaginal ultrasound in 2D, at time of ovulation induction.",[13,14,15,16],[46,51,55,59],{"type":47,"name":48,"description":49,"armGroupLabels":50,"otherNames":10},"DIAGNOSTIC_TEST","Blood samples for the analysis of biomarkers.","We will collect several blood samples:\n\n* One at day 8 of the cycle: measurements of P, E2, Na, K, CL, CO2, Osmolality, PRL, direct renin, PAC, Nt-proBNP, Relaxin-2 and VEGF.\n* One for cycle follow up between day 8 and ovulation: measurement of P, E2, LH\n* One at day 7 after ovulation induction: measurements of P, E2, Na, K, CL, CO2, Osmolality, PRL, direct renin, PAC, Nt-proBNP, Relaxin-2 and VEGF.",[9,18,22,26,30,34,38,42],{"type":47,"name":52,"description":53,"armGroupLabels":54,"otherNames":10},"Transvaginal ultrasound for follicle and endometrium measurements.","A transvaginal ultrasound will be performed after day 8 of the cycle to evaluate a 2D measurement of the growing follicle, as well as a measurement of the endometrial thickness to evaluate readiness for ovulation induction.",[9,18,22,26,30,34,38,42],{"type":47,"name":56,"description":57,"armGroupLabels":58,"otherNames":10},"Mean Arterial Pressure measurement.","The MAP will be measured at cycle day 7 and 7 days post-ovulation induction to follow cardiovascular adaptations.",[9,18,22,26,30,34,38,42],{"type":60,"name":61,"description":62,"armGroupLabels":63,"otherNames":10},"DRUG","Ovitrelle injection for ovulation induction","When patient is deemed ready for ovulation based on follicle size, blood results and endometrium, she will be asked to inject Ovitrelle 250 micrograms to induce ovulation in a controlled and timed manner.",[9,18,22,26,30,34,38,42],[65],{"name":66,"role":67,"phone":68,"phoneExt":10,"email":69},"Caroline Roelens","CONTACT","0032 2 477 9887","caroline.roelens@uzbrussel.be",[71],{"facility":72,"status":10,"city":73,"state":10,"zip":74,"country":75,"countryCode":76,"cosmosGeoPoint":77,"geoPoint":82,"contacts":83},"UZ Brussel","Jette","1090","Belgium","BE",{"type":78,"coordinates":79},"Point",[80,81],4.33419,50.87309,{"lat":81,"lon":80},[84],{"name":66,"role":67,"phone":68,"phoneExt":10,"email":69},{"type":86,"investigatorFullName":87,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Noa Wauters","Doctor","100642286","corpus-luteum-function-and-cardiovascular-adaptation-in-a-natural-mock-cycle-100642286",false,"NCT07648381","Corpus Luteum Function and Cardiovascular Adaptation in a Natural MOCK Cycle.","CLEAR","Inclusion Criteria:\n\n* Age below 40 years\n* Regular menstrual cycles (between 25-35 days)\n* Normal BMI between 18.5 and 35\n\nExclusion Criteria:\n\n* Underlying renal or cardiac disease\n* Hypertension\n* Diabetes mellitus\n* Contraceptive use less than 3 months before MOCK cycle, including: IUD (hormonal and copper), hormonal patch, contraceptive pill (combination and mini), hormonal intravaginal ring, contraceptive implant, contraceptive injection.\n* Ovarian stimulation during the previous three months\n* History of recurrent pregnancy loss (defined as 2 or more previous pregnancy losses before 24 weeks gestation).",true,"FEMALE","18 Years","40 Years",{"count":101,"type":102},118,"ESTIMATED","OBSERVATIONAL","In infertility treatment, embryos are created in vitro after eggs have been fertilised by sperm using in vitro fertilisation or intracytoplasmic sperm injection techniques. These embryos, resulting from hormonal ovarian stimulation, can be transferred shortly after egg retrieval (fresh transfer) or frozen for later use. Both natural menstrual cycles and artificial cycles (using hormones to mimic a normal cycle) can prepare the uterus for embryo transfer. Patients with regular menstrual cycles often prefer the non-medicated approach. However, these cycles offer less flexibility in timing because they rely on ovulation. As the number of FET cycles increases worldwide, scientists are exploring the possibility of inducing ovulation in smaller follicles to increase the flexibility of natural cycles. However, the safety for future pregnancies is unknown. This study aims to better understand the function of the corpus luteum, the follicle remnant in the ovary after ovulation, by measuring several factors that change throughout the cycle due to substances produced by the corpus luteum. The results of the study will have a direct impact on clinical practice by increasing the flexibility of frozen transfer cycles.",[106,107,108,109],"Menstrual Cycle","Luteal Phase Progesterone Levels","Luteal Phase Adaptation","MOCK Cycle","NOT_YET_RECRUITING","2026-06-09",{"date":113,"type":114},"2026-06-15","ACTUAL",{"date":116,"type":102},"2026-07-01",{"date":118,"type":102},"2028-09",{"name":5,"class":6},1]