[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567257":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":21,"locations":10,"responsibleParty":27,"collaborators":10,"id":29,"slug":30,"hasResults":31,"nctId":32,"briefTitle":33,"officialTitle":33,"acronym":34,"eligibilityCriteria":35,"healthyVolunteers":36,"sex":37,"minAge":38,"maxAge":39,"enrollmentInfo":40,"targetDuration":43,"studyType":44,"phases":10,"briefSummary":45,"conditions":46,"keywords":50,"overallStatus":53,"whyStopped":10,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":10},{"fullName":5,"class":6},"Second Affiliated Hospital of Wenzhou Medical University","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Trial volunteers",null,"Trial volunteers refer to healthy individuals undergoing physical examinations at our hospital or recruited healthy university students.",{"label":13,"type":10,"description":14,"interventionNames":10},"Cervical lesions","Patients with cervical lesions, including those with uterine fibroids, cervical cancer, endometrial cancer, and ovarian cancer.",{"label":16,"type":10,"description":17,"interventionNames":10},"persistent HPV infection","Persistent HPV infection refers to the infection by the same type of HPV for more than 12 months.",{"label":19,"type":10,"description":20,"interventionNames":10},"Non-persistent HPV infection","Non-persistent HPV infection refers to the absence of HPV infection.",[22],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Xueqiong Zhu","CONTACT","+8613606640759","zjwzzxq@163.com",{"type":28,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100567257","correlation-between-selenium-levels-in-human-tissues-and-hpv-related-cervical-lesions-and-outcomes-100567257",false,"NCT06665841","Correlation Between Selenium Levels in Human Tissues and HPV-related Cervical Lesions and Outcomes","SeHPV","Inclusion Criteria:\n\n* Aged 18 to 65 years;\n* No history of sexual activity within the past 3 days;\n* No history of cervical surgery;\n* No history of using contraceptives, hormone therapy, or exposure to metals;\n* No history of cardiovascular, cerebrovascular, liver, kidney, or thyroid diseases;\n* All participants must sign a written informed consent form prior to sampling and agree to cooperate with the study.\n\nExclusion Criteria:\n\n* Previous diagnosis of HPV positivity and those who have received treatment;\n* Pregnant individuals;\n* Individuals who refuse to cooperate.",true,"FEMALE","18 Years","65 Years",{"count":41,"type":42},200,"ESTIMATED","12 Months","OBSERVATIONAL","This study investigates the relationship between selenium levels in human tissues and the persistence of HPV (human papillomavirus) infection, particularly focusing on cervical-related lesions. The main objectives are to explore the correlation between selenium levels in different body samples (hair, nails, urine, and blood) and to evaluate selenium's potential protective effects against HPV persistence and its progression to cervical lesions.\n\nKey goals of the study include:\n\nDetermining whether non-invasive monitoring (e.g., hair, nails, urine) can accurately reflect blood selenium levels.\n\nUnderstanding how selenium levels fluctuate in women with persistent HPV infection, and whether selenium supplementation can reduce the risk of HPV-related cervical disease progression.\n\nExploring selenium's role in enhancing immune function, especially in older adults, to help clear HPV infection.\n\nBy recruiting volunteers for selenium level testing and tracking HPV-positive women over time, this research aims to provide evidence on the effectiveness of selenium in preventing cervical cancer progression and potentially clearing HPV infections.",[47,48,49],"Cervical Intraepithelial Neoplasia (CIN)","Cervical Cancer","Persistent HPV Infection",[51,49,52],"Selenium","Cervical Lesions","NOT_YET_RECRUITING","2024-10-28",{"date":56,"type":57},"2024-10-30","ACTUAL",{"date":59,"type":42},"2024-11-01",{"date":61,"type":42},"2027-12-31",{"name":5,"class":6}]