[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100367949":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":10,"centralContacts":50,"locations":56,"responsibleParty":77,"collaborators":10,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":10,"eligibilityCriteria":85,"healthyVolunteers":82,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":92,"studyType":93,"phases":10,"briefSummary":94,"conditions":95,"keywords":10,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Jessa Hospital","OTHER",[8,19],{"label":9,"type":10,"description":11,"interventionNames":12},"study group",null,"all patients at least 18 years of age who present bilateral vestibulopathy on vestibular investigations according to the Barany criteria",[13,14,15,16,17,18],"Diagnostic Test: vestibular test 1","Diagnostic Test: vestibular test 2","Diagnostic Test: vestibular evoked myogenic potentials","Diagnostic Test: audiometry","Diagnostic Test: CT and MR imaging of temporal bone","Genetic: p.P51S mutation",{"label":20,"type":10,"description":21,"interventionNames":22},"control group","DFNA9 patients carrying the p.P51S mutation in COCH gene presenting bilateral vestibulopathy according to the Barany criteria",[13,14,15,16,17,18],[24,29,33,37,41,45],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"DIAGNOSTIC_TEST","vestibular test 1","videonystagmography",[20,9],{"type":25,"name":30,"description":31,"armGroupLabels":32,"otherNames":10},"vestibular test 2","video head impulse test",[20,9],{"type":25,"name":34,"description":35,"armGroupLabels":36,"otherNames":10},"vestibular evoked myogenic potentials","vestibular evoked myogenic potentials to measure the function of otolith organs",[20,9],{"type":25,"name":38,"description":39,"armGroupLabels":40,"otherNames":10},"audiometry","tonal liminar audiometric thresholds",[20,9],{"type":25,"name":42,"description":43,"armGroupLabels":44,"otherNames":10},"CT and MR imaging of temporal bone","Ct and MR imaging of temporal bone",[20,9],{"type":46,"name":47,"description":48,"armGroupLabels":49,"otherNames":10},"GENETIC","p.P51S mutation","analysis of presence of p.P51S mutation in COCH",[20,9],[51],{"name":52,"role":53,"phone":54,"phoneExt":10,"email":55},"sebastien p JanssensdeVarebeke, MD","CONTACT","011337420","drsjanssens@gmail.com",[57],{"facility":5,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"RECRUITING","Hasselt","Limburg","3500","Belgium","BE",{"type":65,"coordinates":66},"Point",[67,68],5.33781,50.93106,{"lat":68,"lon":67},[71,74],{"name":72,"role":53,"phone":73,"phoneExt":10,"email":55},"sebastien P Janssens, MD","011 337420",{"name":75,"role":76,"phone":10,"phoneExt":10,"email":10},"sebastien PF Janssens, MD","PRINCIPAL_INVESTIGATOR",{"type":76,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Sebastien Janssens de Varebeke","principal investigator","100367949","correlation-of-radiological-lesions-with-vestibular-function-in-patients-with-bilateral-vestibulopathy-100367949",false,"NCT04070937","Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy","Inclusion Criteria:\n\n* must meet the Barany criteria for bilateral vestibulopathy: bilaterally pathological horizontal angu- lar VOR gain \\\u003C0.6, measured by the video-HIT5 or scleral-coil technique and\u002For\n* reduced caloric response6 (sum of bither- mal max. peak SPV on each side \\\u003C6◦\u002Fsec7) and\u002For\n* reduced horizontal angular VOR gain \\\u003C0.1 upon sinusoidal stimulation on a rota- tory chair (0.1 Hz, Vmax = 50◦ \u002Fsec) and a phase lead \\>68 degrees (time constant \\\u003C5 sec).\n* must be 18 or older\n\nExclusion Criteria:\n\n* \\\u003C 18 y\n* does not meet Barany criteria for BV\n* contraindication for CT and MR imaging","ALL","18 Years","90 Years",{"count":90,"type":91},40,"ESTIMATED","2 Years","OBSERVATIONAL","In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well.\n\nThe purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.",[96,97,98,99],"Hearing Loss, Sensorineural","Bilateral Vestibular Deficiency","DFNA9","Radiology","2021-08-24",{"date":102,"type":103},"2021-08-25","ACTUAL",{"date":105,"type":103},"2019-09-01",{"date":107,"type":91},"2026-10-30",{"name":5,"class":6},1]