[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617176":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":34,"centralContacts":34,"locations":34,"responsibleParty":39,"collaborators":34,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":34,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":34,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":69,"whyStopped":34,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":34},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"ADHD Active rTMS","EXPERIMENTAL","Children and adolescents with ADHD receive high-frequency rTMS over the right dorsolateral prefrontal cortex (10 Hz, 1200-1500 pulses per session, 100-110% of resting motor threshold) for 15 sessions over 3 weeks in addition to standard care.",[13],"Device: Active repetitive transcranial magnetic stimulation (rTMS)",{"label":15,"type":16,"description":17,"interventionNames":18},"ADHD Sham rTMS","SHAM_COMPARATOR","Children and adolescents with ADHD receive sham rTMS using the same session schedule and procedures as the active ADHD rTMS arm, with coil positioning and sound mimicking stimulation but without effective magnetic pulses, plus standard care.",[19],"Device: Sham repetitive transcranial magnetic stimulation (sham rTMS)",{"label":21,"type":10,"description":22,"interventionNames":23},"ASD Active rTMS","Children and adolescents with autism spectrum disorder receive low-frequency (1 Hz) or intermittent theta-burst rTMS over bilateral dorsolateral prefrontal cortex (about 1200 pulses per session) for 15 sessions over 3 weeks, according to the protocol and ethical approval, plus standard care.",[13],{"label":25,"type":16,"description":26,"interventionNames":27},"ASD Sham rTMS","Children and adolescents with autism spectrum disorder receive sham rTMS over bilateral dorsolateral prefrontal cortex with identical session number and duration as the active ASD rTMS arm, but without effective stimulation, plus standard care.",[19],[29,35],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DEVICE","Active repetitive transcranial magnetic stimulation (rTMS)","Active repetitive transcranial magnetic stimulation delivered using a figure-of-eight coil. For ADHD, high-frequency 10 Hz rTMS is applied over the right dorsolateral prefrontal cortex at 100-110% resting motor threshold, 1200-1500 pulses per session, 15 sessions over 3 weeks. For ASD, 1 Hz inhibitory rTMS or intermittent theta-burst stimulation is applied over bilateral dorsolateral prefrontal cortex with approximately 1200 pulses per session, 15 sessions over 3 weeks.",[9,21],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Sham repetitive transcranial magnetic stimulation (sham rTMS)","Sham rTMS using the same device and schedule as active treatment, with coil positioning and acoustic cues mimicking stimulation but without delivering effective magnetic pulses. Fifteen sham sessions are administered over 3 weeks for ADHD and ASD participants in the sham arms, in addition to standard clinical care.",[15,25],{"type":40,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","Amaal Emad Khairy","Resident at Neuropsychiatry Department, Assiut University","100617176","cortical-excitability-and-role-of-non-invasive-brain-stimulation-in-adhd-and-autism-100617176",false,"NCT07315217","Cortical Excitability and Role of Non Invasive Brain Stimulation in ADHD and AUTISM","Cortical Excitability and Role of Non Invasive Brain Stimulation in ADHD and AUTISM : Double Blind Randomized Clinical Trial","Inclusion Criteria:\n\n* Age 6-19 years.\n* ASD trial: DSM-5 diagnosis of ASD confirmed by CARS-2.\n* ADHD trial: DSM-5 diagnosis of ADHD confirmed by structured interview\u002FCONORS\n* IQ ≥ 70.\n* Stable medication for ≥4 weeks (if any).\n\nExclusion Criteria:\n\n* Epilepsy or seizure history.\n* Metallic implants or devices incompatible with TMS.\n* Severe psychiatric comorbidity (e.g., psychosis).\n* Inability to tolerate TMS procedures.",true,"ALL","6 Years","19 Years",{"count":55,"type":56},80,"ESTIMATED","INTERVENTIONAL",[59],"NA","This double-blind, randomized, sham-controlled clinical trial will evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on children and adolescents with attention-deficit\u002Fhyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and matched healthy controls. Participants aged 6-19 years will be assigned to active or sham rTMS protocols targeting the dorsolateral prefrontal cortex over 3 weeks, with assessment of changes in disorder-specific symptoms and cortical excitability. The study aims to determine the safety, feasibility, and preliminary efficacy of rTMS as a non-invasive neuromodulation approach in pediatric neurodevelopmental disorders.",[62,63,64,65],"Cortical Excitability","Brain Stimulation","ADHD","Autism",[67,68,64,65],"Cortical excitability","non invasive brain stimulation","NOT_YET_RECRUITING","2025-12-18",{"date":72,"type":73},"2026-01-02","ACTUAL",{"date":75,"type":56},"2026-01",{"date":77,"type":56},"2027-02",{"name":5,"class":6}]